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A skin biopsy with histologic examination can distinguish malignant melanoma from a benign nevus, seborrheic keratosis, and pigmented basal cell epithelioma; it can also determine tumor thickness. Physical examination, paying particular attention to lymph nodes, can point to metastatic involvement. (See Staging malignant melanoma, page 135.)
Baseline laboratory studies include complete blood count with differential, erythrocyte sedimentation rate, platelet count, liver function studies, and urinalysis. Depending on the depth of tumor invasion and metastatic spread, baseline diagnostic studies may also include chest X-ray and a computed tomography (CT) scan of the chest and abdomen. Signs of bone metastasis may call for a bone scan; CNS metastasis necessitates a CT scan of the brain.
Source: Professional Guide to Diseases (Eighth Edition), 2005
A skin biopsy with histologic examination can distinguish malignant melanoma from a benign nevus, seborrheic keratosis, and pigmented basal cell epithelioma; it can also determine tumor thickness. Physical examination, paying particular attention to lymph nodes, can point to metastatic involvement.
Baseline laboratory studies include a complete blood count with differential, erythrocyte sedimentation rate, platelet count, liver function studies, and urinalysis. Depending on the depth of tumor invasion and metastasis, baseline diagnostic studies may also include a chest X-ray and computed tomography (CT) scan of the chest and abdomen. Signs of bone metastasis may call for a bone scan; CNS metastasis, a CT scan of the brain.
Source: Handbook of Diseases, 2003
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