Clinical Trials for Acromegaly

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Acromegaly is grouped into the following categories:-

• View by trial name
• View by drugs used in Acromegaly clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Acromegaly:

• Sandostatin LAR Depot Vs. Surgery for Treating Acromegaly - This study has been completed (Current: 23 Nov 2006)
• The Treatment and Natural History of Acromegaly - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study of the Effect of Growth Hormone-Releasing Hormone Antagonist on Growth Hormone Release in Acromegaly - This study has been completed (Current: 23 Nov 2006)
• Measurement of Outcome of Surgical Treatment in Patients With Acromegaly - This study is currently recruiting patients (Current: 23 Nov 2006)
• Safety and Efficacy of Octreotide Long Acting Release (LAR) in Treatment Nave Acromegalic Patients - This study has been completed (Current: 23 Nov 2006) - Octreotide LAR
• Comparable Effects of Lanreotide Autogel and Octreotide LAR on GH, IGF-I Levels and Patient Satisfaction - This study has been completed (Current: 23 Nov 2006) - Lanreotide Autogel and Octreotide LAR
• An Extension Study to Assess the Long-Term Safety and Efficacy of Pasireotide in Patients With Acromegaly - This study is no longer recruiting patients (Current: 23 Nov 2006) - Pasireotide
• Octreotide Efficacy and Safety in First-Line Acromegalic Patients - This study has been suspended (Current: 23 Nov 2006) - Octreotide
• Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency - This study is currently recruiting patients (Current: 23 Nov 2006) - Genotropin
• Lanreotide Autogel in Patients With Acromegaly Previously Treated With Octreotide LAR - This study is currently recruiting patients (Current: 23 Nov 2006) - Lanreotide (Autogel formulation)
• Use of Somatostatin Analogue Therapy as Primary Medical Treatment of Acromegaly - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Somatuline Autogel
• Safety and Efficacy of Long-Acting Repeatable Octreotide Acetate for Injectable Suspension Vs. Surgery in Treatment-nave Patients With Acromegaly - This study has been completed (Current: 23 Nov 2006) - Octreotide LAR – pituitary surgery
• Efficacy/Safety of Octreotide Acetate in Patients With Uncontrolled Acromegaly - This study is currently recruiting patients (Current: 23 Nov 2006) - Octreotide acetate
• Efficacy of Octreotide Acetate and Cabergoline in Patients With Acromegaly - This study is currently recruiting patients (Current: 23 Nov 2006) - Octreotide acetate and cabergoline
• Study Comparing SOM230 Subcutaneously and Sandostatin Subcutaneously in Acromegalic Patients - This study is no longer recruiting patients (Current: 23 Nov 2006) - SOM230 s.c.,Sandostatin s.c
• Pegvisomant And Sandostatin LAR Combination Study - This study is no longer recruiting patients (Current: 23 Nov 2006) - Pegvisomant/ Sandostatin LAR,Sandostatin LAR,Pegvisomant
• A Study To Compare The Efficacy And Safety Of Pegvisomant To That Of Sandostatin Lar Depot In Patients With Acromegaly - This study is no longer recruiting patients (Current: 23 Nov 2006) - Pegvisomant,Sandostatin LAR
• Long Term Study With B2036-PEG - This study is no longer recruiting patients (Current: 23 Nov 2006) - Pegvisomant
• Somatuline Autogel: Acromegaly Self/Partner Injection Study - This study is no longer recruiting patients (Current: 23 Nov 2006) - Lanreotide (Autogel formulation)
• Canadian Pegvisomant Compassionate Study In Acromegalic Patients - This study is no longer recruiting patients (Current: 23 Nov 2006) - Pegvisomant treatment
• Efficacy and Safety of Lanreotide Autogel (60, 90 or 120 Mg) in Acromegalic Patients - This study has been completed (Current: 23 Nov 2006) - Lanreotide (Autogel formulation)
• A Study to Evaluate the Risk of Developing a Heart Condition Called Valvular Regurgitation in Patients With Acromegaly Treated With Either Lanreotide or Octreotide - This study has been completed (Current: 23 Nov 2006)
• Efficacy and Safety Study of Varying Doses of Lanreotide Autogel in Patients With Acromegaly - This study has been completed (Current: 23 Nov 2006) - Lanreotide (Autogel formulation)
• Study Assessing the Efficacy and Safety of Octreotide Acetate in Patients With Acromegaly, With Micro or Macroadenomas - This study has been completed (Current: 23 Nov 2006) - Octreotide acetate
• Estrogen Treatment in Acromegalic Women - This study is currently recruiting patients (Current: 23 Nov 2006) - Alesse
• Lanreotide Autogel and Pegvisomant Combination Therapy in Acromegalic Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - lanreotide (Autogel formulation),Pegvisomant
• Preoperative Octreotide Treatment of Patients With Acromegaly - This study is no longer recruiting patients (Current: 23 Nov 2006) - octreotide
• A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome - This study has been completed (Current: 23 Nov 2006) - Pegvisomant

Drugs used in Clinical Trials for Acromegaly

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Acromegaly:

• Alesse - Estrogen Treatment in Acromegalic Women - This study is currently recruiting patients (Current: 23 Nov 2006)
• Genotropin - Effects of Growth Hormone Administration on Cardiovascular Risk in Cured Acromegalics With Growth Hormone Deficiency - This study is currently recruiting patients (Current: 23 Nov 2006)
• Lanreotide (Autogel Formulation) - Lanreotide Autogel and Pegvisomant Combination Therapy in Acromegalic Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Lanreotide (Autogel formulation) - Efficacy and Safety Study of Varying Doses of Lanreotide Autogel in Patients With Acromegaly - This study has been completed (Current: 23 Nov 2006)
• Lanreotide (Autogel formulation) - Efficacy and Safety of Lanreotide Autogel (60, 90 or 120 Mg) in Acromegalic Patients - This study has been completed (Current: 23 Nov 2006)
• Lanreotide (Autogel formulation) - Lanreotide Autogel in Patients With Acromegaly Previously Treated With Octreotide LAR - This study is currently recruiting patients (Current: 23 Nov 2006)
• Lanreotide (Autogel formulation) - Somatuline Autogel: Acromegaly Self/Partner Injection Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Lanreotide Autogel and Octreotide LAR - Comparable Effects of Lanreotide Autogel and Octreotide LAR on GH, IGF-I Levels and Patient Satisfaction - This study has been completed (Current: 23 Nov 2006)
• Octreotide LAR – pituitary surgery - Safety and Efficacy of Long-Acting Repeatable Octreotide Acetate for Injectable Suspension Vs. Surgery in Treatment-nave Patients With Acromegaly - This study has been completed (Current: 23 Nov 2006)
• Octreotide LAR - Safety and Efficacy of Octreotide Long Acting Release (LAR) in Treatment Nave Acromegalic Patients - This study has been completed (Current: 23 Nov 2006)
• Octreotide acetate and cabergoline - Efficacy of Octreotide Acetate and Cabergoline in Patients With Acromegaly - This study is currently recruiting patients (Current: 23 Nov 2006)
• Octreotide acetate - Efficacy/Safety of Octreotide Acetate in Patients With Uncontrolled Acromegaly - This study is currently recruiting patients (Current: 23 Nov 2006)
• Octreotide acetate - Study Assessing the Efficacy and Safety of Octreotide Acetate in Patients With Acromegaly, With Micro or Macroadenomas - This study has been completed (Current: 23 Nov 2006)
• Octreotide - Octreotide Efficacy and Safety in First-Line Acromegalic Patients - This study has been suspended (Current: 23 Nov 2006)
• Octreotide - Preoperative Octreotide Treatment of Patients With Acromegaly - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pasireotide - An Extension Study to Assess the Long-Term Safety and Efficacy of Pasireotide in Patients With Acromegaly - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pegvisomant treatment - Canadian Pegvisomant Compassionate Study In Acromegalic Patients - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pegvisomant/ Sandostatin LAR - Pegvisomant And Sandostatin LAR Combination Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pegvisomant - A Study To Compare The Efficacy And Safety Of Pegvisomant To That Of Sandostatin Lar Depot In Patients With Acromegaly - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pegvisomant - A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome - This study has been completed (Current: 23 Nov 2006)
• Pegvisomant - Lanreotide Autogel and Pegvisomant Combination Therapy in Acromegalic Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Pegvisomant - Long Term Study With B2036-PEG - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pegvisomant - Pegvisomant And Sandostatin LAR Combination Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• SOM230 s.c. - Study Comparing SOM230 Subcutaneously and Sandostatin Subcutaneously in Acromegalic Patients - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Sandostatin LAR - A Study To Compare The Efficacy And Safety Of Pegvisomant To That Of Sandostatin Lar Depot In Patients With Acromegaly - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Sandostatin LAR - Pegvisomant And Sandostatin LAR Combination Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Sandostatin s.c. - Study Comparing SOM230 Subcutaneously and Sandostatin Subcutaneously in Acromegalic Patients - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Somatuline Autogel - Use of Somatostatin Analogue Therapy as Primary Medical Treatment of Acromegaly - This study is not yet open for patient recruitment (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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