Clinical Trials for Adrenal insufficiency

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Adrenal insufficiency is grouped into the following categories:-

• View by trial name
• View by drugs used in Adrenal insufficiency clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Adrenal insufficiency:

• Adrenal Function in Critical Illness - This study is currently recruiting patients (Current: 23 Nov 2006)
• Adrenal Function in Patients With Newly Diagnosed Lung Cancer - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006) - Fludrocortisone
• Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency - This study has been completed (Current: 23 Nov 2006) - Ovine Corticotropin-Releasing Hormone (oCRH)
• Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006) - Hydrocortisone Administration (Standard of Care Therapy)
• Adrenal Function After Living Kidney Donation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency - This study has been completed (Current: 23 Nov 2006) - dehydroepiandrosterone
• Ovarian Follicle Function in Patients With Premature Ovarian Failure - This study is currently recruiting patients (Current: 23 Nov 2006) - OCRH
• Study of Glyceryl Trierucate and Glyceryl Trioleate (Lorenzo's Oil) Therapy in Male Children With Adrenoleukodystrophy - This study is currently recruiting patients (Current: 23 Nov 2006) - glyceryl trierucate,glyceryl trioleate
• Study of Bile Acids in Patients With Peroxisomal Disorders - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - chenodeoxycholic acid,cholic acid,ursodiol
• Randomized Study of Beta Interferon and Thalidomide in Patients With Adrenoleukodystrophy - This study has been completed (Current: 23 Nov 2006) - glyceryl trierucate,glyceryl trioleate,interferon beta,thalidomide
• Study of Pulmonary Complications in Pediatric Patients With Storage Disorders Undergoing Allogeneic Hematopoietic Stem Cell Transplantation - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Study of Oral Cholic Acid in Patients With Inborn Errors of Bile Acid Synthesis - This study has been completed (Current: 23 Nov 2006)
• Stem Cell Transplant for Inborn Errors of Metabolism - This study is currently recruiting patients (Current: 23 Nov 2006) - Busulfan,Cyclophosphamide,ATG
• Clinical Study and Gene Mutation Analysis of Adrenoleukodystrophy in Taiwanese Children - This study is currently recruiting patients (Current: 23 Nov 2006)
• HSCT for High Risk Inherited Inborn Errors - This study is currently recruiting patients (Current: 23 Nov 2006) - Campath,Clofarabine
• Corticosteroid Therapy of Septic Shock Corticus - This study is no longer recruiting patients (Current: 23 Nov 2006) - hydrocortisone sodium succinate
• Low-Dose Hydrocortisone in Acutely Burned Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - hydrocortisone 200 mg/day
• Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006) - insulin,hydrocortisone,fludrocortisone

Drugs used in Clinical Trials for Adrenal insufficiency

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Adrenal insufficiency:

• ATG - Stem Cell Transplant for Inborn Errors of Metabolism - This study is currently recruiting patients (Current: 23 Nov 2006)
• Busulfan - Stem Cell Transplant for Inborn Errors of Metabolism - This study is currently recruiting patients (Current: 23 Nov 2006)
• Campath - HSCT for High Risk Inherited Inborn Errors - This study is currently recruiting patients (Current: 23 Nov 2006)
• Chenodeoxycholic Acid - Study of Bile Acids in Patients With Peroxisomal Disorders - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Cholic Acid - Study of Bile Acids in Patients With Peroxisomal Disorders - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Clofarabine - HSCT for High Risk Inherited Inborn Errors - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cyclophosphamide - Stem Cell Transplant for Inborn Errors of Metabolism - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dehydroepiandrosterone - Phase III Randomized, Double-Blind, Placebo-Controlled Study of Dehydroepiandrosterone Replacement for Primary Adrenal Insufficiency - This study has been completed (Current: 23 Nov 2006)
• Fludrocortisone - Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006)
• Fludrocortisone - Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Glyceryl Trierucate - Randomized Study of Beta Interferon and Thalidomide in Patients With Adrenoleukodystrophy - This study has been completed (Current: 23 Nov 2006)
• Glyceryl Trierucate - Study of Glyceryl Trierucate and Glyceryl Trioleate (Lorenzo's Oil) Therapy in Male Children With Adrenoleukodystrophy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Glyceryl Trioleate - Randomized Study of Beta Interferon and Thalidomide in Patients With Adrenoleukodystrophy - This study has been completed (Current: 23 Nov 2006)
• Glyceryl Trioleate - Study of Glyceryl Trierucate and Glyceryl Trioleate (Lorenzo's Oil) Therapy in Male Children With Adrenoleukodystrophy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydrocortisone 200 Mg/Day - Low-Dose Hydrocortisone in Acutely Burned Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydrocortisone Administration (Standard of Care Therapy) - Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in Patients With Severe Sepsis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydrocortisone Sodium Succinate - Corticosteroid Therapy of Septic Shock Corticus - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Hydrocortisone - Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006)
• Insulin - Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock - This study is currently recruiting patients (Current: 23 Nov 2006)
• Interferon Beta - Randomized Study of Beta Interferon and Thalidomide in Patients With Adrenoleukodystrophy - This study has been completed (Current: 23 Nov 2006)
• OCRH - Ovarian Follicle Function in Patients With Premature Ovarian Failure - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ovine Corticotropin-Releasing Hormone (oCRH) - Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency - This study has been completed (Current: 23 Nov 2006)
• Thalidomide - Randomized Study of Beta Interferon and Thalidomide in Patients With Adrenoleukodystrophy - This study has been completed (Current: 23 Nov 2006)
• Ursodiol - Study of Bile Acids in Patients With Peroxisomal Disorders - This study is not yet open for patient recruitment (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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