Adrenoleukodystrophy

Introduction: Adrenoleukodystrophy

Adrenoleukodystrophy: Adrenoleukodystrophy (ALD) is a rare, inherited metabolic disorder that afflicts the young boy Lorenzo Odone, whose story is told in the 1993 film "Lorenzo's oil." In ... more about Adrenoleukodystrophy.

Adrenoleukodystrophy: A rare disorder which has characteristic symptoms of Addison disease (adrenocortical insufficiency) and Schilder disease (cerebral sclerosis). Bronze skin, brain sclerosis and demyelination are the main symptoms. More detailed information about the symptoms, causes, and treatments of Adrenoleukodystrophy is available below.

Symptoms of Adrenoleukodystrophy

• Seizures
• Impaired motor function
• Impaired vision
• Swallowing difficulties
• Attention problems

See full list of 46 symptoms of Adrenoleukodystrophy

Home Diagnostic Testing

Home medical testing related to Adrenoleukodystrophy:

• Fatigue: Related Home Tests:
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  • Home Thyroid Function Tests
  • Home Adrenal Function Tests
  • Home Calcium Deficiency Tests
  • Home HIV Tests
• Adrenal Gland Health: Home Testing:

Medical Textbooks Online about Adrenoleukodystrophy

Book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.

Causes of Adrenoleukodystrophy

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Prognosis for Adrenoleukodystrophy

Prognosis for Adrenoleukodystrophy: Prognosis for patients with ALD is generally poor except after successful bone marrow transplantation. Death may occur within 1 to 10 years after the onset of symptoms due to disease progression. (Source: excerpt from NINDS Adrenoleukodystrophy Information Page: NINDS)

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Reseach about Adrenoleukodystrophy

Visit our research pages for current research about Adrenoleukodystrophy treatments.

Clinical Trials for Adrenoleukodystrophy

The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.

Some of the clinical trials listed on ClinicalTrials.gov for Adrenoleukodystrophy include:

• Study of Glyceryl Trierucate and Glyceryl Trioleate (Lorenzo's Oil) Therapy in Male Children With Adrenoleukodystrophy - This study is currently recruiting patients (Current: 23 Nov 2006) - glyceryl trierucate,glyceryl trioleate
• Study of Bile Acids in Patients With Peroxisomal Disorders - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - chenodeoxycholic acid,cholic acid,ursodiol
• Randomized Study of Beta Interferon and Thalidomide in Patients With Adrenoleukodystrophy - This study has been completed (Current: 23 Nov 2006) - glyceryl trierucate,glyceryl trioleate,interferon beta,thalidomide
• Study of Pulmonary Complications in Pediatric Patients With Storage Disorders Undergoing Allogeneic Hematopoietic Stem Cell Transplantation - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Study of Oral Cholic Acid in Patients With Inborn Errors of Bile Acid Synthesis - This study has been completed (Current: 23 Nov 2006)

See full list of 9 Clinical Trials for Adrenoleukodystrophy

Statistics for Adrenoleukodystrophy

• Medical statistics for Adrenoleukodystrophy
• Prevalence and incidence statistics for Adrenoleukodystrophy
• Death and Mortality statistics for Adrenoleukodystrophy
• Society statistics for Adrenoleukodystrophy

Types of Adrenoleukodystrophy

• Classic childhood ALD - severe form in boys
• Adult-onset ALD - milder form in young adults
• Female carrier ALD - mild form in female carrying the gene.
• Neonatal ALD

Read more about Types of Adrenoleukodystrophy

Medical Guidebooks and Ebooks for Adrenoleukodystrophy

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Stories from Users Related to Adrenoleukodystrophy

• Adrenal dysfunction?
• So many untreated symptoms... enlarged liver, cerebral atrophy, acid reflux, etc.
• bronze skin.
• cerebral atrophy
• Leukodystrophy
• please help my mum! Paraplegia
• X-linked agamglobulinemia
• Is it Addison's Disease?
• x-ray help
• addisons disease
• spastic legs
• Severe adrenal rushes
• paraplegia....
• could this be Spastic pelvic floor syndrome?
• atrophy in cerebellum
• Diffused Disc
• Arm atrophy
• Rounded shadows & "wispy" x-ray images around my lower tibia
• Right arm atrophy
• Depo Provera Shot... Please help, I'm at my wits end x

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Article Excerpts about Adrenoleukodystrophy

Genes and Disease by the National Center for Biotechnology (Excerpt)

Adrenoleukodystrophy (ALD) is a rare, inherited metabolic disorder that afflicts the young boy Lorenzo Odone, whose story is told in the 1993 film "Lorenzo's oil." In this disease, the fatty covering (myelin sheath) on nerve fibers in the brain is lost, and the adrenal gland degenerates, leading to progressive neurological disability and death. (Source: Genes and Disease by the National Center for Biotechnology)

NINDS Adrenoleukodystrophy Information Page: NINDS (Excerpt)

Adrenoleukodystrophy (ALD) is a rare, genetic disorder characterized by the breakdown or loss of the myelin sheath surrounding nerve cells in the brain and progressive dysfunction of the adrenal gland. ALD is one of a group of genetic disorders called the leukodystrophies that cause damage to the myelin sheath, the fatty covering — which acts as an insulator — on nerve fibers in the brain. (Source: excerpt from NINDS Adrenoleukodystrophy Information Page: NINDS)

Definitions of Adrenoleukodystrophy:

A syndrome combining the characteristics of adrenocortical insufficiency (Addison disease) with those of cerebral sclerosis (Schilder disease). Skin bronzing and sclerosis of the brain and demyelination are the principal manifestations. - (Source - Diseases Database)

Adrenoleukodystrophy is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Adrenoleukodystrophy, or a subtype of Adrenoleukodystrophy, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)