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Diagnosis is generally made clinically because most SCID infants suffer recurrent overwhelming infections within 1 year of birth. Some infants are diagnosed after a severe reaction to vaccination.
Defective humoral immunity is difficult to detect before age 5 months. Before then, even normal infants have very small amounts of serum immunoglobulin (Ig) M and IgA. Normal IgG levels merely reflect maternal IgG.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Clinical indications point to the diagnosis. Most infants with SCID suffer recurrent overwhelming infections within 1 year of birth. Some are diagnosed after a severe reaction to vaccination.
Defective humoral immunity is difficult to detect before an infant is 5 months old. Before age 5 months, even normal infants have very small amounts of the serum immunoglobulins (Ig) IgM and IgA, and normal IgG levels merely reflect maternal IgG. However, severely diminished or absent T-cell number and function and lymph node biopsy showing absence of lymphocytes can confirm the diagnosis of SCID.
Source: Handbook of Diseases, 2003
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