Alpha 1-Antitrypsin Deficiency

Alpha 1-Antitrypsin Deficiency: Introduction

Alpha 1-Antitrypsin Deficiency: A rare disorder characterized by the development of lung disease in adults and liver disease in adults and children. More detailed information about the symptoms, causes, and treatments of Alpha 1-Antitrypsin Deficiency is available below.

Symptoms of Alpha 1-Antitrypsin Deficiency

• Shortness of breath
• Increased difficulty exercising
• Wheezing
• Weight loss
• Repeated respiratory infections
• more symptoms...»

See full list of 19 symptoms of Alpha 1-Antitrypsin Deficiency

Alpha 1-Antitrypsin Deficiency: Complications

Read more about complications of Alpha 1-Antitrypsin Deficiency.

Wrongly Diagnosed with Alpha 1-Antitrypsin Deficiency?

• Misdiagnosis of Alpha 1-Antitrypsin Deficiency

Misdiagnosis and Alpha 1-Antitrypsin Deficiency

Vitamin B12 deficiency under-diagnosed: The condition of Vitamin B12 deficiency is a possible misdiagnosis of various conditions, such as multiple sclerosis (see symptoms of multiple sclerosis). See symptoms of Vitamin B12 deficiency or misdiagnosis of multiple sclerosis....read more »

Read more about Misdiagnosis and Alpha 1-Antitrypsin Deficiency

Causes of Alpha 1-Antitrypsin Deficiency

Read more about causes of Alpha 1-Antitrypsin Deficiency.

Evidence Based Medicine Research for Alpha 1-Antitrypsin Deficiency

Medical research articles related to Alpha 1-Antitrypsin Deficiency include:

• Lung Transplantation (Treatment)
• Lung Transplantation (Overview)
• Lung Transplantation (Diagnosis)
• Alpha1-Antitrypsin Deficiency (Treatment)
• Alpha1-Antitrypsin Deficiency (Overview)
• Diagnosing COPD
• Budd-Chiari Syndrome
• Alpha-1-Antitrypsin Deficiency
• more research...»

Click here to find more evidence-based articles on the TRIP Database

Videos for Alpha 1-Antitrypsin Deficiency

Reseach about Alpha 1-Antitrypsin Deficiency

Visit our research pages for current research about Alpha 1-Antitrypsin Deficiency treatments.

Clinical Trials for Alpha 1-Antitrypsin Deficiency

The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.

Some of the clinical trials listed on ClinicalTrials.gov for Alpha 1-Antitrypsin Deficiency include:

• Characterization of the Pathobiology of Early Lung Destruction in Alpha 1-Antitrypsin Deficient Individuals - This study has been completed (Current: 23 Nov 2006)
• Study of Genotype and Phenotype in Patients With Alpha 1-Antitrypsin Deficiency - This study has been terminated (Current: 23 Nov 2006)
• The Comparison of the Pharmacokinetic, Safety and Tolerability of Alpha-1 MP and Prolastin in Adult alpha1-Antitrypsin Deficient Patients. - This study is currently recruiting patients (Current: 23 Nov 2006) - alpha-1 proteinase inhibitor (human)
• The Safety and Tolerability of Alpha-1 MP in Subjects With Alpha-1-Antitrypsin (AAT) Deficiency. - This study is currently recruiting patients (Current: 23 Nov 2006) - alpha-1 proteinase inhibitor (human)
• Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients - This study is no longer recruiting patients (Current: 23 Nov 2006) - Alpha-1-Proteinase Inhibitor (Human)
• more trials...»

See full list of 14 Clinical Trials for Alpha 1-Antitrypsin Deficiency

Statistics for Alpha 1-Antitrypsin Deficiency

• Medical statistics for Alpha 1-Antitrypsin Deficiency
• Prevalence and incidence statistics for Alpha 1-Antitrypsin Deficiency
• Death and Mortality statistics for Alpha 1-Antitrypsin Deficiency
• Society statistics for Alpha 1-Antitrypsin Deficiency

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Definitions of Alpha 1-Antitrypsin Deficiency:

Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN, leading primarily to degradation of elastin of the alveolar walls, as well as other structural proteins of a variety of tissues. (From Scriver, Beaudet, Sly, & Valle, The Metabolic and Molecular Bases of Inherited Disease, 7th ed, p4125) - (Source - Diseases Database)

Alpha 1-Antitrypsin Deficiency is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Alpha 1-Antitrypsin Deficiency, or a subtype of Alpha 1-Antitrypsin Deficiency, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Alpha 1-Antitrypsin Deficiency as a "rare disease".
Source - Orphanet