Prevalence and Incidence of Alpha 1-Antitrypsin Deficiency

Prevalance of Alpha 1-Antitrypsin Deficiency:

1 per 5,000 - 7,000 people suffer from alpha-1 antitrypsin deficiency in North America, Genetics Home Reference website ... see also overview of Alpha 1-Antitrypsin Deficiency.

Prevalance Rate:

approx 1 in 5,000 or 0.02% or 54,400 people in USA [Source statistic for calcuation: "1 per 5,000 - 7,000 people suffer from alpha-1 antitrypsin deficiency in North America, Genetics Home Reference website" -- see also general information about data sources]

Alpha 1-Antitrypsin Deficiency: Rare Disease

Alpha 1-Antitrypsin Deficiency is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Alpha 1-Antitrypsin Deficiency, or a subtype of Alpha 1-Antitrypsin Deficiency, affects less than 200,000 people in the US population.

Ophanet, who are a consortium of European partners, currently defines a condition rare when if affects 1 person per 2,000. They list Alpha 1-Antitrypsin Deficiency as a "rare disease". More information about Alpha 1-Antitrypsin Deficiency is available from Orphanet

Alpha 1-Antitrypsin Deficiency Prevalence: Book Excerpts

• Alpha 1-Antitrypsin Deficiency - epidemiology - Alpha 1-Antitrypsin Deficiency

Prevalence/Incidence of Alpha 1-Antitrypsin Deficiency: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the prevalence and/or incidence of Alpha 1-Antitrypsin Deficiency.

Alpha 1-Antitrypsin Deficiency: Alpha 1-Antitrypsin Deficiency - epidemiology
(The 5-Minute Pediatric Consult)

• One of the most common inherited disorders worldwide, although most patients do not have severe disease
• Most common genetic cause of emphysema in adults and liver disease in children

Alpha 1-Antitrypsin Deficiency - incidence

• Incidence of the PiZZ genotype is highest in whites in North America, Australia, and Europe.
• In the US, the PIZ allele frequency is approximately 14.5 per 1000, with lower rates among Asians, blacks, and Latinos and higher rates among whites.
• The incidence of classical α
• Only ~10% of PiZZ or PiSZ individuals will develop clinically significant liver disease.

Alpha 1-Antitrypsin Deficiency - prevalence

• An estimated 70,000–100,000 individuals are affected in North America.
• As many as 25 million people in the US are carriers of a mutant allele.

» READ BOOK EXCERPT ONLINE »

Source: The 5-Minute Pediatric Consult, 2008

About prevalence and incidence statistics:

The term 'prevalence' of Alpha 1-Antitrypsin Deficiency usually refers to the estimated population of people who are managing Alpha 1-Antitrypsin Deficiency at any given time. The term 'incidence' of Alpha 1-Antitrypsin Deficiency refers to the annual diagnosis rate, or the number of new cases of Alpha 1-Antitrypsin Deficiency diagnosed each year. Hence, these two statistics types can differ: a short-lived disease like flu can have high annual incidence but low prevalence, but a life-long disease like diabetes has a low annual incidence but high prevalence. For more information see about prevalence and incidence statistics.

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