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What is Amyotrophic lateral sclerosis?

What is Amyotrophic lateral sclerosis?

  • Amyotrophic lateral sclerosis: A motor neuron disease involving progressive degeneration and eventual destruction of the function of nerves that control voluntary movement.
  • Amyotrophic lateral sclerosis: progressive degeneration of the neurons that give rise to the corticospinal tract and of the motor cells of the brain stem and spinal cord, resulting in a deficit of upper and lower motor neurons.
    Source - Diseases Database
  • Amyotrophic lateral sclerosis: thickening of tissue in the motor tracts of the lateral columns and anterior horns of the spinal cord; results in progressive muscle atrophy that starts in the limbs.
    Source - WordNet 2.1

Amyotrophic lateral sclerosis is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Amyotrophic lateral sclerosis, or a subtype of Amyotrophic lateral sclerosis, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Amyotrophic lateral sclerosis as a "rare disease".
Source - Orphanet

Amyotrophic lateral sclerosis: Introduction

Types of Amyotrophic lateral sclerosis:

Broader types of Amyotrophic lateral sclerosis:

How many people get Amyotrophic lateral sclerosis?

Prevalance of Amyotrophic lateral sclerosis: 4-8 per 1000,000 people suffer from amyotrophic lateral sclerosis worldwide, Genetics Home Reference website
Prevalance Rate of Amyotrophic lateral sclerosis: approx 1 in 250,000 or 0.00% or 1,087 people in USA [about data]
Incidence (annual) of Amyotrophic lateral sclerosis: estimated 5,000 people are diagnosed with amyotrophic lateral sclerosis in the US, Genetics Home Reference website
Incidence Rate of Amyotrophic lateral sclerosis: approx 1 in 54,400 or 0.00% or 5,000 people in USA [about data]
Prevalance of Amyotrophic lateral sclerosis: affecting as many as 20,000 Americans with 5,000 new cases occurring in the United States each year. (Source: excerpt from NINDS Amyotrophic Lateral Sclerosis Information Page: NINDS)

Who gets Amyotrophic lateral sclerosis?

Patient Profile for Amyotrophic lateral sclerosis: Middle age.

Profile for Amyotrophic lateral sclerosis: ALS strikes in mid-life. Men are about one-and-a-half times more likely to have the disease as women. (Source: excerpt from NINDS Amyotrophic Lateral Sclerosis Information Page: NINDS)

Gender Profile for Amyotrophic lateral sclerosis: Men 1.5 times more than women.

How serious is Amyotrophic lateral sclerosis?

Prognosis of Amyotrophic lateral sclerosis: Poor. Degenerative. Non-curable. Usually fatal within 5 years.
Complications of Amyotrophic lateral sclerosis: see complications of Amyotrophic lateral sclerosis
Prognosis of Amyotrophic lateral sclerosis: ALS is usually fatal within five years after diagnosis. (Source: excerpt from NINDS Amyotrophic Lateral Sclerosis Information Page: NINDS)
3-year survival rate for Amyotrophic lateral sclerosis: 50% live more than 3 years after diagnosis of ALS in America (Robert Packard Research Center at John Hopkins Hospital)
5-year survival rate for Amyotrophic lateral sclerosis: 20% live more than 5 years after diagnosis of ALS in America (Robert Packard Research Center at John Hopkins Hospital)
10-year survival rate for Amyotrophic lateral sclerosis: 10% live more than 10 years after diagnosis of ALS in America (Robert Packard Research Center at John Hopkins Hospital)

What causes Amyotrophic lateral sclerosis?

Causes of Amyotrophic lateral sclerosis: see causes of Amyotrophic lateral sclerosis
Causes of Amyotrophic lateral sclerosis: ALS occurs when specific nerve cells in the brain and spinal cord that control voluntary movement gradually degenerate. The loss of these motor neurons causes the muscles under their control to weaken and waste away, leading to paralysis. (Source: excerpt from NINDS Amyotrophic Lateral Sclerosis Information Page: NINDS)
Risk factors for Amyotrophic lateral sclerosis: see risk factors for Amyotrophic lateral sclerosis

What are the symptoms of Amyotrophic lateral sclerosis?

Symptoms of Amyotrophic lateral sclerosis: see symptoms of Amyotrophic lateral sclerosis

Complications of Amyotrophic lateral sclerosis: see complications of Amyotrophic lateral sclerosis

Can anyone else get Amyotrophic lateral sclerosis?

Inheritance: see inheritance of Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis: Testing

Diagnostic testing: see tests for Amyotrophic lateral sclerosis.

Misdiagnosis: see misdiagnosis and Amyotrophic lateral sclerosis.

How is it treated?

Treatments for Amyotrophic lateral sclerosis: see treatments for Amyotrophic lateral sclerosis
Research for Amyotrophic lateral sclerosis: see research for Amyotrophic lateral sclerosis

Organs Affected by Amyotrophic lateral sclerosis:

Organs and body systems related to Amyotrophic lateral sclerosis include:

Name and Aliases of Amyotrophic lateral sclerosis

Main name of condition: Amyotrophic lateral sclerosis

Other names or spellings for Amyotrophic lateral sclerosis:

ALS, Lou Gehrig's disease, Charcot disease, motor neuron disease, amyotrophic lateral sclerosis, ALS1, Amyotrophic lateral sclerosis 1

Lou Gehrig disease Source - Diseases Database

ALS, Lou Gehrig's disease
Source - WordNet 2.1

ALS, ALS1, Amyotrophic lateral sclerosis 1, Lou-Gehrigs disease, ALS1, Amyotrophic lateral sclerosis 1, Lou-Gehrigs disease, ALS, ALS1, Amyotrophic lateral sclerosis 1
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)

Research the causes of these diseases that are similar to, or related to, Amyotrophic lateral sclerosis:


 » Next page: Online Medical Textbooks for Amyotrophic lateral sclerosis

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