Cure Research for Anal Cancer

Cure Research list for Anal Cancer:

The list of research areas and treatments under analysis mentioned in various sources for Anal Cancer includes:

• Capecitabine
• Irinotecan
• Edrecolomab
• Amifostine
• Anitmetabolite (E)-2'-fluoromethylene-2'-deoxyxytidine
• Uracil
• Calcium folinate

Curable Types of Anal Cancer

Possibly curable or rare types of Anal Cancer include:

• Localised cancer of the anus without metastasis to the inguinal lymph nodes
• Anal cancer T1, T2, T3 grade
• more curable types...»

Rare Types of Anal Cancer:

Some rare types of Anal Cancer include:

• Inflammatory bowel disease associated anal cancer
• Hemorrhoids associated anal cancer
• Anal fistulas associated with anal cancers
• more rare types...»

Latest Treatments for Anal Cancer

Some of the more recent treatments for Anal Cancer include:

• 5FU/ Mitomycin
• Radiation
• Selenium
• more treatments...»

Medical Research Breakthroughs and Anal Cancer

Standard treatment for Anal Cancer is preferred over Experimental drug: It has been reported that experimental chemotherapy treatment with the drug cisplatin (administered prior to other treatments) for patients with anal canal cancer failed to increase disease-free survival rates and also increased the likelihood of colostomy procedures when compared to the standard treatment regimen. The first treatment therapy for anal canal cancer commonly is chemo radiation. Radiation treatment combined with the anti-cancer drugs like fluorouracil and mitomycin has a 5-year disease-free survival rate of about 65%. In recent studies conducted, researchers have obtained promising results and have suggested that an effective treatment for anal canal cancer could be achieved by shrinking that cancer in the primary tumour and in the lymph node(s) before chemotherapy. The researchers found that the 5-year disease-free survival rate in patients treated with fluorouracil plus mitomycin and followed by radiotherapy was 60%; for patients treated with fluorouracil plus cisplatin and followed by radiotherapy, it was 54%. In addition, the 5-year overall survival rates were 75% and 70% for the mitomycin-based group the cisplatin-based group, respectively. Cancer-related deaths were more frequent in the cisplatin-based group (54 patients) than in the mitomycin-based group (28 patients). Patients in the mitomycin-based treatment group had 5-year local-regional recurrence rates of 25% and distant metastasis rates (spreading of the disease to other regions of the body) of 15%. These rates were 33% and 19% for the cisplatin-based treatment group, respectively. It was also found that patients in the mitomycin-based group had more severe hematologic (blood) toxicity than the other group. Significantly higher cumulative rates of colostomy were found in patients receiving cisplatin (19% vs. 10%), the researchers have suggested that primary therapy with cisplatin should be avoided in this patient population. Relative to the continued standard of concurrent chemo radiation with fluorouracil and mitomycin, options to further improve disease-free and colostomy-free survival , researchers have tried to explore targeted agents (e.g., results with concurrent cetuximab plus radiation for head/neck cancer), dose escalation with intensity-modulated radiation plus concurrent chemotherapy, and surgical excision of residual cancer after concurrent chemo radiation at an earlier interval, when sphincter preservation may still be feasible in select patients.

Anal Cancer Treatment: Book Excerpts

• Treatment - Rectal Pain
• Treatment - Colorectal cancer
• Treatment - Malignant spinal neoplasms
• Patient counseling - Rectal pain
• Emergency interventions - Hematochezia [Rectal bleeding]
• Treatment - Colorectal cancer
• Patient counseling - Rectal pain
• Nursing considerations - Rectal pain
• Nursing considerations - Hematochezia [Rectal bleeding]

Clinical Trials for Anal Cancer

Some of the clinical trials for Anal Cancer include:

• Chemoprevention of Anal Neoplasia Arising Secondary to Anogenital Human Papillomavirus Infection in Persons With HIV Infection. - This study has been completed (Current: 23 Nov 2006) - Isotretinoin,Interferon alfa-2a
• A Study of Anal Cancer Development in HIV Infected People - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - cisplatin,fluorouracil,mitomycin
• Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - cisplatin,fluorouracil
• Vaccine Therapy in Treating Patients With Advanced or Recurrent Cancer - This study is no longer recruiting patients (Current: 23 Nov 2006) - human papillomavirus 16 E6 peptide,human papillomavirus 16 E7 peptide
• more trials...»

Evidence Based Medicine Research for Anal Cancer

Medical research papers related to Anal Cancer include:

• Panitumumab (Vectibix) - Metastatic colorectal cancer ? 1st line
• Comparison of patient- and clinician-collected anal cytology samples to screen for human papillomavirus-associated anal intraepithelial neoplasia in men who have sex with men.
• Capecitabine (Xeloda) - Metastatic colorectal cancer
• British HIV Association guidelines for HIV-associated malignancies 2008
• Incidence of types of cancer among HIV-infected persons compared with the general population in the United States, 1992-2003.
• Canadian Consensus Guidelines on Human Papillomavirus
• Human papillomavirus (HPV)
• Bevacizumab (Avastin) - In combination with fluoropyrimidine-based chemotherapy is indicated for treatment of patients with metastatic carcinoma of the colon or rectum.
• Should all patients with rectal bleeding be referred for further investigations even if have strong history and examination consistent with haemorrhoids?
• Adapting your practice: treatment and recommendations for homeless patients with HIV/AIDS.
• UK National Guidelines for HIV Testing
• UK national guidelines for HIV testing 2008
• Anal cancer.
• Anal cancer
• Anal dysplasia screening
• Guidelines for the management of colorectal cancer
• Canadian Consensus Guidelines on Human Papillomavirus
• Resectable rectal cancer.
• Lower GI surgery
• 2007 UK guidelines for the management of sexual and reproductive health (SRH) of people living with HIV infection
• Human papilloma virus
• HPV
• Human papilloma virus.
• Anal Cancer
• Elevated anal squamous cell carcinoma risk associated with benign inflammatory anal lesions.
• Anal Carcinoma
• Adult screening
• HPV infection and genital warts. Sexually transmitted diseases treatment guidelines 2006.
• Human papillomavirus
• Colorectal Adenocarcinoma

Click here to find more evidence-based articles on the TRIP Database

 » Next page: Deaths from Anal Cancer

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