Symptoms of Angelman syndrome

List of symptoms of Angelman syndrome:

The list of signs and symptoms mentioned in various sources for Angelman syndrome includes the 38 symptoms listed below:

• Retardation
• Unusually happy demeanor
• Microcephaly (small head)
• Large jaws
• Jerky movements
• Unstable jerky gait
• Hand flapping
• Developmental delay
• Diminished speech
• Laughter
• Severe mental retardation
• Motor development delay
• Fits of inappropriate laughter
• Absent speech
• Microbrachycephaly
• Blond hair
• Eye anomalies
• Decreased eye pigmentation
• Pale blue eyes
• Maxillary hypoplasia
• Deep-set eyes
• Large mouth
• Tongue protrusion
• Widely spaced teeth
• Protruding jaw
• Ataxia
• Jerky arm movements
• Puppet-like gait
• Characteristic arm position
• Arms held up and flexed at wrists and elbows
• Seizures
• Major motor seizures
• Akinetic seizures
• EEG abnormalities
• Reduced muscle tone
• Hyperreflexia
• Cerebral atrophy
• Left hand preference

Note that Angelman syndrome symptoms usually refers to various symptoms known to a patient, but the phrase Angelman syndrome signs may refer to those signs only noticable by a doctor.

More ways to research these symptoms: To research other symptoms use the symptom center, or to research causes of more than one symptom in combination, try our multi-symptom search.

Research More About Angelman syndrome

Do I have Angelman syndrome?

• Angelman syndrome: Introduction
• How serious is it?
• Treatments for Angelman syndrome
• More about Angelman syndrome

Less Common Symptoms of Angelman syndrome:

Ocassionally other symptoms may also present themselves as symptoms of Angelman syndrome. 6 of the more common ones are included in the list below:

• Scoliosis
• Hypopigmentation
• Strabismus
• Myopia
• Hypermetropia
• Nystagmus

More about symptoms of Angelman syndrome:

More information about symptoms of Angelman syndrome and related conditions:

• Other diseases with similar symptoms and common misdiagnoses
• Symptoms that may be caused by complications of Angelman syndrome

Other Possible Causes of these Symptoms

Click on any of the symptoms below to see a full list of other causes including diseases, medical conditions, toxins, drug interactions, or drug side effect causes of that symptom.

• Absent speech - see all causes of Loss of speech
• Ataxia - see all causes of Ataxia
• Blond hair - see all causes of Hair symptoms
• Characteristic arm position - see all causes of Arm symptoms
• Deep-set eyes - see all causes of Deep-set eyes
• Developmental delay - see all causes of Developmental problems
• Diminished speech - see all causes of Speech symptoms
• Hand flapping - see all causes of Hand symptoms
• Hyperreflexia - see all causes of Hyperreflexia
• Jerky movements - see all causes of Jerky movements
• Large jaws - see all causes of Jaw symptoms
• Large mouth - see all causes of Large mouth
• Laughter - see all causes of Laughter
• Microcephaly (small head) - see all causes of Head symptoms
• Protruding jaw - see all causes of Protruding jaw
• Reduced muscle tone - see all causes of Muscle weakness
• Retardation - see all causes of Mental retardation
• Seizures - see all causes of Seizures
• Tongue protrusion - see all causes of Swollen tongue
• Unstable jerky gait - see all causes of Walking symptoms
• Unusually happy demeanor - see all causes of Mania
• Widely spaced teeth - see all causes of Widely spaced teeth

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Article Excerpts About Symptoms of Angelman syndrome:

Genes and Disease by the National Center for Biotechnology (Excerpt)

Angelman syndrome (AS) is an uncommon neurogenetic disorder characterized by mental retardation, abnormal gait, speech impairment, seizures, and an inappropriate happy demeanor that includes frequent laughing, smiling, and excitability. The uncoordinated gait and laughter have caused some people to refer to this disorder as the "happy puppet" syndrome. (Source: Genes and Disease by the National Center for Biotechnology)

NINDS Angelman Syndrome Information Page: NINDS (Excerpt)

Angelman syndrome is a neurological disorder characterized by severe congenital mental retardation, unusual facial appearance, and muscular abnormalities. Symptoms of Angelman syndrome include unstable jerky gait, hand flapping, unusually happy demeanor, developmental delay, lack of or diminished speech, and microcephaly (small head). Epilepsy may develop in the early years of life, however it may decrease with age. Patients may also have balance problems. (Source: excerpt from NINDS Angelman Syndrome Information Page: NINDS)

Angelman syndrome as a Cause of Symptoms or Medical Conditions

When considering symptoms of Angelman syndrome, it is also important to consider Angelman syndrome as a possible cause of other medical conditions. The Disease Database lists the following medical conditions that Angelman syndrome may cause:

• Ataxia
• Fits
• Genomic imprinting
• Hypopigmentation
• Learning disability
• Macrostomia
• Microcephaly
• Prognathia
• Strabismus, concomitant

Symptom statistics for Angelman syndrome:

The following are statistics from various sources about the symptoms of Angelman syndrome or signs of Angelman syndrome:

• 100% of people with Angelman Syndrome have functionally severe developmental delay in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 100% of people with Angelman Syndrome have speech impairment in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 100% of people with Angelman Syndrome have movement or balance disorder, usually ataxia of gait and/or tremulous movement of limbs in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 100% of people with Angelman Syndrome have behavioural uniqueness such as frequent laughter/smiling, apparent happy demeanour, easily excitable personality often with hand flapping movements, hyper motoric behaviour and short attention span in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 80% of people with Angelman Syndrome have a delayed or disproportionate head circumference growth in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 80% of people with Angelman Syndrome have seizures which usually start before the age of 3 in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 80% of people with Angelman Syndrome have abnormal EEG’s in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome have a flat area at the back of the head in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome have a groove at the back of the head in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome have a protruding tongue in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome exhibit tongue thrusting with sucking or swallowing disorders in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome have a feeding problems while infants in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome have a projecting jaw in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome have a wide mouth with spread out teeth in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome drool frequently in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome chew or mouth excessively in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome have strabisumsin the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome have hypopigmented skin in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome have a hyperactive lower limb deep tendon reflexes in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome are sensitive to heat in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome suffer sleep disturbances in the US (Dr Harry Angelman, Angelman Syndrome Foundation)
• 20-80% of people with Angelman Syndrome are fascinated by water in the US (Dr Harry Angelman, Angelman Syndrome Foundation)

Medical articles and books on symptoms:

These general reference articles may be of interest in relation to medical signs and symptoms of disease in general:

• How serious is Angelman syndrome?
• More about Angelman syndrome
• Online Diagnosis
• Self Diagnosis Pitfalls
• Pitfalls of Online Diagnosis
• Symptoms of the Silent Killer Diseases
• Lesser known silent killer diseases
• Books on signs and symptoms

Full list of premium articles on symptoms and diagnosis

About signs and symptoms of Angelman syndrome:

The symptom information on this page attempts to provide a list of some possible signs and symptoms of Angelman syndrome. This signs and symptoms information for Angelman syndrome has been gathered from various sources, may not be fully accurate, and may not be the full list of Angelman syndrome signs or Angelman syndrome symptoms. Furthermore, signs and symptoms of Angelman syndrome may vary on an individual basis for each patient. Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they are indeed Angelman syndrome symptoms.