Clinical Trials for Bacteremia

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Bacteremia is grouped into the following categories:-

• View by trial name
• View by drugs used in Bacteremia clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Bacteremia:

• Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus - This study has been completed (Current: 23 Nov 2006) - daptomycin
• Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections - This study is currently recruiting patients (Current: 23 Nov 2006) - 2% chlorhexidine gluconate impregnated cloth
• The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study - This study is currently recruiting patients (Current: 23 Nov 2006) - Synbiotic 2000
• Safety and Efficacy of MBI 226 for the Prevention of Central Venous Catheter-Related Bloodstream Infections - This study has been completed (Current: 23 Nov 2006) - MBI 226
• Antibiotic Treatment for Patients With Infections of Short Term In-Dwelling Vascular Catheters Due to a Specific Bacteria (Gram Positive Bacteria) - This study has been completed (Current: 23 Nov 2006) - Antibiotic,Vancomycin,Oxacillin,Dicloxacillin
• Safety and Efficacy of Dalbavancin Versus Vancomycin in the Treatment of Catheter-Related Bloodstream Infections - This study is no longer recruiting patients (Current: 23 Nov 2006) - dalbavancin
• Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections - This study is currently recruiting patients (Current: 23 Nov 2006) - Cefazolin IV,Linezolid IV,Vancomycin (IV)
• Alcohol Locks for the Prevention of Tunneled Catheter-Related Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• Pharmacodynamic Parameters of Two Different Doses of Cefepime - This study is currently recruiting patients (Current: 23 Nov 2006)
• Colistin IV-Pilot Study: Pharmacokinetics and Pharmacodynamics of Intravenous Colistin - This study is currently recruiting patients (Current: 23 Nov 2006)
• Prevention of Bacteremia Induced by Debridement of Pressure Ulcer - This study is currently recruiting patients (Current: 23 Nov 2006)
• Clinical Trial Comparing Safety and Pharmacokinetics of Standard Antibiotic Therapy, Plus Aurexis or Placebo, for Treatment of Staphylococcus Aureus Bacteremia (SAB) - This study has been completed (Current: 23 Nov 2006) - Aurexis®
• Virulence Determinants in S Aureus Bacteremia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Clinical Outcome of Neonates With GBS Positive Culture-12 Year Retrospective Study - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Trial of Prophylactic Versus Empirical Vancomycin for the Prevention of Streptococcal Sepsis After Hematopoietic Cell Transplantation - This study has been completed (Current: 23 Nov 2006) - Empirical Vancomycin,Prophylactic Vancomycin
• A Study to Learn More About MAC Disease and the Use of Anti-HIV Drugs in Patients With Advanced HIV Infection - This study has been completed (Current: 23 Nov 2006) - Nelfinavir mesylate,Nevirapine,Azithromycin
• Rifabutin Therapy for the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia in HIV Positive Patients With CD4 Counts = or < 200: Treatment IND Study - This study has been completed (Current: 23 Nov 2006) - Rifabutin
• Tolerance, Safety, and Activity of Rifapentine Alone and in Combination Therapy in AIDS Patients With Mycobacterium Avium Complex Bacteremia. - This study has been completed (Current: 23 Nov 2006) - Rifapentine,Ethambutol hydrochloride,Clarithromycin,Azithromycin
• Daptomycin for the Treatment of Infections Due to Gram-Positive Bacteria - This study has been completed (Current: 23 Nov 2006) - daptomycin
• Moxifloxacin Prophylaxis - This study is currently recruiting patients (Current: 23 Nov 2006) - moxifloxacin,placebo
• Gram Negative Bacteremia, Risk Factors for Failure of Therapy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Chart Review of Outcome of Treatment for S. Aureus Bacteremia - This study is currently recruiting patients (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Bacteremia

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Bacteremia:

• 2% chlorhexidine gluconate impregnated cloth - Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• Antibiotic - Antibiotic Treatment for Patients With Infections of Short Term In-Dwelling Vascular Catheters Due to a Specific Bacteria (Gram Positive Bacteria) - This study has been completed (Current: 23 Nov 2006)
• Aurexis® - Clinical Trial Comparing Safety and Pharmacokinetics of Standard Antibiotic Therapy, Plus Aurexis or Placebo, for Treatment of Staphylococcus Aureus Bacteremia (SAB) - This study has been completed (Current: 23 Nov 2006)
• Azithromycin - A Study to Learn More About MAC Disease and the Use of Anti-HIV Drugs in Patients With Advanced HIV Infection - This study has been completed (Current: 23 Nov 2006)
• Azithromycin - Tolerance, Safety, and Activity of Rifapentine Alone and in Combination Therapy in AIDS Patients With Mycobacterium Avium Complex Bacteremia. - This study has been completed (Current: 23 Nov 2006)
• Cefazolin IV - Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• Clarithromycin - Tolerance, Safety, and Activity of Rifapentine Alone and in Combination Therapy in AIDS Patients With Mycobacterium Avium Complex Bacteremia. - This study has been completed (Current: 23 Nov 2006)
• Dalbavancin - Safety and Efficacy of Dalbavancin Versus Vancomycin in the Treatment of Catheter-Related Bloodstream Infections - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Daptomycin - Daptomycin for the Treatment of Infections Due to Gram-Positive Bacteria - This study has been completed (Current: 23 Nov 2006)
• Daptomycin - Daptomycin in the Treatment of Subjects With Infective Endocarditis or Bacteremia Due to S. Aureus - This study has been completed (Current: 23 Nov 2006)
• Dicloxacillin - Antibiotic Treatment for Patients With Infections of Short Term In-Dwelling Vascular Catheters Due to a Specific Bacteria (Gram Positive Bacteria) - This study has been completed (Current: 23 Nov 2006)
• Empirical Vancomycin - Trial of Prophylactic Versus Empirical Vancomycin for the Prevention of Streptococcal Sepsis After Hematopoietic Cell Transplantation - This study has been completed (Current: 23 Nov 2006)
• Ethambutol hydrochloride - Tolerance, Safety, and Activity of Rifapentine Alone and in Combination Therapy in AIDS Patients With Mycobacterium Avium Complex Bacteremia. - This study has been completed (Current: 23 Nov 2006)
• Linezolid IV - Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• MBI 226 - Safety and Efficacy of MBI 226 for the Prevention of Central Venous Catheter-Related Bloodstream Infections - This study has been completed (Current: 23 Nov 2006)
• Moxifloxacin - Moxifloxacin Prophylaxis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nelfinavir mesylate - A Study to Learn More About MAC Disease and the Use of Anti-HIV Drugs in Patients With Advanced HIV Infection - This study has been completed (Current: 23 Nov 2006)
• Nevirapine - A Study to Learn More About MAC Disease and the Use of Anti-HIV Drugs in Patients With Advanced HIV Infection - This study has been completed (Current: 23 Nov 2006)
• Oxacillin - Antibiotic Treatment for Patients With Infections of Short Term In-Dwelling Vascular Catheters Due to a Specific Bacteria (Gram Positive Bacteria) - This study has been completed (Current: 23 Nov 2006)
• Placebo - Moxifloxacin Prophylaxis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Prophylactic Vancomycin - Trial of Prophylactic Versus Empirical Vancomycin for the Prevention of Streptococcal Sepsis After Hematopoietic Cell Transplantation - This study has been completed (Current: 23 Nov 2006)
• Rifabutin - Rifabutin Therapy for the Prevention of Mycobacterium Avium Complex (MAC) Bacteremia in HIV Positive Patients With CD4 Counts = or < 200: Treatment IND Study - This study has been completed (Current: 23 Nov 2006)
• Rifapentine - Tolerance, Safety, and Activity of Rifapentine Alone and in Combination Therapy in AIDS Patients With Mycobacterium Avium Complex Bacteremia. - This study has been completed (Current: 23 Nov 2006)
• Synbiotic 2000 - The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• Vancomycin (IV) - Linezolid in the Treatment of Hemodialysis Patients With Catheter-Related Gram-Positive Bloodstream Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• Vancomycin - Antibiotic Treatment for Patients With Infections of Short Term In-Dwelling Vascular Catheters Due to a Specific Bacteria (Gram Positive Bacteria) - This study has been completed (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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