Clinical Trials for Cataracts

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Cataracts is grouped into the following categories:-

• View by trial name
• View by drugs used in Cataracts clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Cataracts:

• Clinical and Genetic Studies of Families With Congenital or Hereditary Cataracts - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dynamic Light Scattering for Studying Lens Aging and Cataract Formation - This study has been completed (Current: 23 Nov 2006)
• Cataract Surgery to Obtain Human Lens Material for the Study of Nuclear Cataracts - This study has been completed (Current: 23 Nov 2006)
• Dynamic Light Scattering Device (DLS) Study of Age-Related Changes in the Lens and Cataracts - This study has been completed (Current: 23 Nov 2006)
• Evaluation of the Age-Related Eye Disease Study (AREDS) Clinical Lens Grading System - This study has been completed (Current: 23 Nov 2006)
• Autoimmune Dysregulation in Pigmentary Glaucoma - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Pilot Study: Dynamic Light Scattering Device for Studying Early Changes in Cataract - This study is currently recruiting patients (Current: 23 Nov 2006)
• Studies of Families With Hereditary Cataracts - This study has been completed (Current: 23 Nov 2006)
• Test of QLS Device to Detect Early Cataracts - This study has been completed (Current: 23 Nov 2006)
• Magnetic Resonance Imaging to Study the Normal Eye - This study has been completed (Current: 23 Nov 2006)
• Combined Phacotube Vs Phacotrabeculectomy:A Randomized Controlled Trial - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Comparison of Three Different Formulations of Prednisolone Acetate 1%. - This study is currently recruiting patients (Current: 23 Nov 2006) - Prednisolone Acetate 1%
• Comparison of the Quality of Vision Provided by AMO Tecnis Z9000 Three-Piece Silicone Posterior Chamber Intraocular Lens and Alcon Laboratories MA60 Acrysof Three-Piece Acrylic Posterior Chamber Intraocular Lens - This study is currently recruiting patients (Current: 23 Nov 2006)
• Absorption of Brimonidine Ophthalmic Solution in the Aqueous Humor of Cataract Patients - This study has been completed (Current: 23 Nov 2006) - Brimonidine Purite
• Bioavailability of Bimatoprost Ophthalmic Solution in Human Aqueous. - This study has been completed (Current: 23 Nov 2006) - Bimatoprost 0.03%
• Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs - This study has been completed (Current: 23 Nov 2006) - Ofloxacin 0.3%,Ciprofloxacin 0.3%,Levofloxacin 0.5%,Ofloxacin 400mg,Ciprofloxacin 400mg,Levofloxacin 250mg
• Hypnosis for Eye Surgery - This study is currently recruiting patients (Current: 23 Nov 2006)
• Safety and Efficacy Study of Topical Bromfenac Versus Placebo to Treat Ocular Inflammation After Cataract Surgery - This study has been completed (Current: 23 Nov 2006) - bromfenac sodium 0.09%
• Phacoemulsification Sleeves - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Study of Interventions to Reduce Disability From Visual Loss in Nursing Home Residents - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Therapeutic Variables in Cataract Surgery Protocol - This study is currently recruiting patients (Current: 23 Nov 2006) - Gatifloxacin,Ketorolac LS,Pred Forte,Moxifloxacin,Nepafenac,EconoPred Plus
• Age-Related Macular Degeneration and Cataract - This study is no longer recruiting patients (Current: 23 Nov 2006) - Vitamin and/or Mineral Supplement
• Long Term Follow-Up of Diabetic Retinopathy - This study has been completed (Current: 23 Nov 2006)
• Infant Aphakia Treatment Study (IATS) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Safety and Efficacy of a Heparin-Coated Intraocular Lens in Uveitis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Age-Related Eye Disease Study (AREDS) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Antioxidants,Zinc
• Randomized Trial of Aspirin and Cataracts in U.S. Physicians - This study has been completed (Current: 23 Nov 2006) - Aspirin
• Randomized Trials of Vitamin Supplements and Eye Disease - This study is no longer recruiting patients (Current: 23 Nov 2006) - Aspirin,Beta-Carotene,Vitamin C,Vitamin E
• The Influence of Vision on Balance, Gait and Falls - This study is currently recruiting patients (Current: 23 Nov 2006)
• Collaborative Italian-American Clinical Trial of Nutritional Supplements and Age-Related Cataract (CTNS) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Centrum
• Posterior Capsule Opacification Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nevanac 3-Month Safety Study With QID Dosing - This study is currently recruiting patients (Current: 23 Nov 2006) - Nevanac 0.1% Ophthalmic Suspension
• Nepafenac Opthalmic Suspension 0.1% Compared to Acular LS for Treatment of Inflammation After Cataract Surgery - This study is no longer recruiting patients (Current: 23 Nov 2006) - Nepafenac Ophthalmic Suspension, 0.1%
• Safety and Efficacy of Next Generation Ophthalmic Irrigating Solution Compared to BSS Plus - This study has been completed (Current: 23 Nov 2006) - Next Generation Ophthalmic Irrigating Solution
• Anesthetic and Dilating Gel for Cataract Surgery - This study is currently recruiting patients (Current: 23 Nov 2006) - Anesthetic Dilating Gel
• Safety of NGOIS Compared to BSS Plus in Pediatric Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Next Generation Ophthalmic Irrigating Solution
• Wavefront Analisys and Contrast Sensitivity of Spherical and Aspherical Intraocular Lenses - This study has been completed (Current: 23 Nov 2006)
• Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% Vs. Bromfenac 0.09% in Cataract Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - ketorolac 0.4%, bromfenac 0.09%
• Comparative Study of Three IOL Power Calculation Formulae for Asian Eyes Shorter Than 22mm or Longer Than 25mm - This study is currently recruiting patients (Current: 23 Nov 2006)
• Improving Vision and Quality of Life in the Nursing Home - This study has been completed (Current: 23 Nov 2006)
• Ketorolac Vs. Steroid in the Prevention of CME - This study is currently recruiting patients (Current: 23 Nov 2006) - Ketorolac, Prednisolone Acetate
• Acular LS Vs. Nevanac in Post Op Inflammation Following Cataract Surgery - This study is currently recruiting patients (Current: 23 Nov 2006) - Ketorolac,Nepafenac
• Efficacy of Topical Cyclosporine Versus Tears for Improving Visual Outcomes Following Multifocal IOL Implantation - This study is currently recruiting patients (Current: 23 Nov 2006) - Topical Cyclosporine, Tears
• A Bioequivalence Study of Tobradex AF - This study is currently recruiting patients (Current: 23 Nov 2006) - Tobradex AF
• Corneal Endothelium Changes After Phacoemulsification in Relation to Hydrodynamic Parameters - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efficacy of Honan Balloon in Intraocular Pressure Reduction Before Phacoemulsification - This study has been completed (Current: 23 Nov 2006)
• Clinical Evaluation of the Use of Sealed Capsule Irrigation With Sodium Chloride During Pediatric Cataract Surgery and IOL Implantation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Modified Intraocular Lens to Reduce Eye Inflammation After Cataract Surgery in Uveitis Patients - This study has been completed (Current: 23 Nov 2006)
• Comparison of the Torsional Handpiece to Conventional Handpiece During Routine Phacoemulsification - This study is currently recruiting patients (Current: 23 Nov 2006)
• Comparison of Acular LS With Lotemax to Prevent Inflammation After Cataract Surgery and Intraocular Lens Implantation - This study is currently recruiting patients (Current: 23 Nov 2006) - Acular LS,Lotemax
• A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery - This study has been completed (Current: 23 Nov 2006) - Prednisolone acetate
• Efficacy/Safety of Antibiotic Steroid Combination in Prevention of Postoperative Inflammation in Cataract Surgery - This study is currently recruiting patients (Current: 23 Nov 2006) - antibiotic/steroid combination
• Surgical Removal of Idiopathic Epiretinal Membrane With and Without the Assistance of Indocyanine Green. - This study has been completed (Current: 23 Nov 2006) - Surgery with and without the aid of Indocyanine Green (ICG)
• Surgical Outcomes After Routine Cataract Extraction & Implantation of a Conventional or Spheric Intraocular Lens - This study has been completed (Current: 23 Nov 2006)
• Comparison of Visual Outcomes and Patient Satisfaction After Cataract Surgery and Implantation of ReSTOR and ReZoom IOLs - This study is currently recruiting patients (Current: 23 Nov 2006)
• Comparison of the Performance of the Infiniti Vision and the Series 20000 Legacy Phacoemulsification Systems - This study has been completed (Current: 23 Nov 2006)
• Repository for Inherited Eye Diseases - This study is currently recruiting patients (Current: 23 Nov 2006)
• Evaluation and Treatment of Pediatric, Developmental, and Genetic Eye Diseases - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Study of Denufosol Tetrasodium Intravitreal Injection in Subjects With Post Cataract Extraction Macular Edema - This study is no longer recruiting patients (Current: 23 Nov 2006) - denufosol tetrasodium (INS37217) Intravitreal Injection
• Family Studies of Eye Traits - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Analysis of Eye Tissue - This study has been completed (Current: 23 Nov 2006)
• Prevalence and Risk of Cataracts in Granulocyte Donors - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dynamic Light Scattering to Study Crystalline Proteins in Young Normal Lenses - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Study of the Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Subjects With Open Angle Glaucoma - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Study of the Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Open Angle Glaucoma Subjects. - This study is no longer recruiting patients (Current: 23 Nov 2006)
• A Study of the Trabecular Micro-Bypass Stent in Combination With Cataract Surgery in Subjects With Newly Diagnosed Open Angle Glaucoma and Subjects Diagnosed With Ocular Hypertension - This study is currently recruiting patients (Current: 23 Nov 2006)
• Phacotrabeculotomy vs. CCI+Phaco in Patients With Borderline Control of Intraocular Pressure - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study of Antibiotic Prophylaxis for Endophthalmitis Following Cataract Surgery - This study is no longer recruiting patients (Current: 23 Nov 2006) - Cefuroxime,Levofloxacin
• A Bioequivalence Study of Tobramycin and Prednisolone Acetate Compared to PredForte - This study is no longer recruiting patients (Current: 23 Nov 2006) - Prednisolone Acetate 1.0%/Tobramycin 0.3%; PredForte 1.0%
• Triamcinolone Vs. Laser for Diabetic Macular Edema - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Triamcinolone acetonide
• Safety/Efficacy of Bromfenac Ophthalmic Solution for Ocular Inflammation and Pain Associated With Cataract Surgery - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - bromfenac ophthalmic solution
• Results of Ocular Compression and Suture Release in Trabeculectomy and Combined Surgery - This study has been completed (Current: 23 Nov 2006)
• Preoperative Topical Gatifloxacin on Anterior Chamber Cultures After Cataract Surgery - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - gatifloxacin ophthalmic (ZYMAR)
• Impact of Systemic Corticosteroid Therapy on Lens Transparency and Quantification of Lens Autofluorescence. - This study has been completed (Current: 23 Nov 2006) - Prednisolone

Drugs used in Clinical Trials for Cataracts

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Cataracts:

• Acular LS - Comparison of Acular LS With Lotemax to Prevent Inflammation After Cataract Surgery and Intraocular Lens Implantation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Anesthetic Dilating Gel - Anesthetic and Dilating Gel for Cataract Surgery - This study is currently recruiting patients (Current: 23 Nov 2006)
• Antibiotic/Steroid Combination - Efficacy/Safety of Antibiotic Steroid Combination in Prevention of Postoperative Inflammation in Cataract Surgery - This study is currently recruiting patients (Current: 23 Nov 2006)
• Antioxidants - Age-Related Eye Disease Study (AREDS) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Aspirin - Randomized Trial of Aspirin and Cataracts in U.S. Physicians - This study has been completed (Current: 23 Nov 2006)
• Aspirin - Randomized Trials of Vitamin Supplements and Eye Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Beta-Carotene - Randomized Trials of Vitamin Supplements and Eye Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Bimatoprost 0.03% - Bioavailability of Bimatoprost Ophthalmic Solution in Human Aqueous. - This study has been completed (Current: 23 Nov 2006)
• Brimonidine Purite - Absorption of Brimonidine Ophthalmic Solution in the Aqueous Humor of Cataract Patients - This study has been completed (Current: 23 Nov 2006)
• Bromfenac Ophthalmic Solution - Safety/Efficacy of Bromfenac Ophthalmic Solution for Ocular Inflammation and Pain Associated With Cataract Surgery - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Bromfenac Sodium 0.09% - Safety and Efficacy Study of Topical Bromfenac Versus Placebo to Treat Ocular Inflammation After Cataract Surgery - This study has been completed (Current: 23 Nov 2006)
• Cefuroxime - Study of Antibiotic Prophylaxis for Endophthalmitis Following Cataract Surgery - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Centrum - Collaborative Italian-American Clinical Trial of Nutritional Supplements and Age-Related Cataract (CTNS) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Ciprofloxacin 0.3% - Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs - This study has been completed (Current: 23 Nov 2006)
• Ciprofloxacin 400mg - Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs - This study has been completed (Current: 23 Nov 2006)
• Denufosol Tetrasodium (Ins37217) Intravitreal Injection - A Study of Denufosol Tetrasodium Intravitreal Injection in Subjects With Post Cataract Extraction Macular Edema - This study is no longer recruiting patients (Current: 23 Nov 2006)
• EconoPred Plus - Therapeutic Variables in Cataract Surgery Protocol - This study is currently recruiting patients (Current: 23 Nov 2006)
• Gatifloxacin Ophthalmic (Zymar) - Preoperative Topical Gatifloxacin on Anterior Chamber Cultures After Cataract Surgery - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Gatifloxacin - Therapeutic Variables in Cataract Surgery Protocol - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ketorolac 0.4%, Bromfenac 0.09% - Aqueous Concentrations and PGE2 Inhibition of Ketorolac 0.4% Vs. Bromfenac 0.09% in Cataract Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ketorolac LS - Therapeutic Variables in Cataract Surgery Protocol - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ketorolac, Prednisolone Acetate - Ketorolac Vs. Steroid in the Prevention of CME - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ketorolac - Acular LS Vs. Nevanac in Post Op Inflammation Following Cataract Surgery - This study is currently recruiting patients (Current: 23 Nov 2006)
• Levofloxacin 0.5% - Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs - This study has been completed (Current: 23 Nov 2006)
• Levofloxacin 250mg - Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs - This study has been completed (Current: 23 Nov 2006)
• Levofloxacin - Study of Antibiotic Prophylaxis for Endophthalmitis Following Cataract Surgery - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Lotemax - Comparison of Acular LS With Lotemax to Prevent Inflammation After Cataract Surgery and Intraocular Lens Implantation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Moxifloxacin - Therapeutic Variables in Cataract Surgery Protocol - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nepafenac Ophthalmic Suspension, 0.1% - Nepafenac Opthalmic Suspension 0.1% Compared to Acular LS for Treatment of Inflammation After Cataract Surgery - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Nepafenac - Acular LS Vs. Nevanac in Post Op Inflammation Following Cataract Surgery - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nepafenac - Therapeutic Variables in Cataract Surgery Protocol - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nevanac 0.1% Ophthalmic Suspension - Nevanac 3-Month Safety Study With QID Dosing - This study is currently recruiting patients (Current: 23 Nov 2006)
• Next Generation Ophthalmic Irrigating Solution - Safety and Efficacy of Next Generation Ophthalmic Irrigating Solution Compared to BSS Plus - This study has been completed (Current: 23 Nov 2006)
• Next Generation Ophthalmic Irrigating Solution - Safety of NGOIS Compared to BSS Plus in Pediatric Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Ofloxacin 0.3% - Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs - This study has been completed (Current: 23 Nov 2006)
• Ofloxacin 400mg - Penetrance of Third Generation Fluoroquinolones in Eyes With Functioning Filtering Blebs - This study has been completed (Current: 23 Nov 2006)
• Pred Forte - Therapeutic Variables in Cataract Surgery Protocol - This study is currently recruiting patients (Current: 23 Nov 2006)
• Prednisolone Acetate 1% - A Comparison of Three Different Formulations of Prednisolone Acetate 1%. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Prednisolone Acetate 1.0%/Tobramycin 0.3%; PredForte 1.0% - A Bioequivalence Study of Tobramycin and Prednisolone Acetate Compared to PredForte - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Prednisolone acetate - A Study to Compare Ocular Safety and Tolerability of Eye Drops Containing Prednisolone Acetate in Patients With Intraocular Inflammation After Cataract Surgery - This study has been completed (Current: 23 Nov 2006)
• Prednisolone - Impact of Systemic Corticosteroid Therapy on Lens Transparency and Quantification of Lens Autofluorescence. - This study has been completed (Current: 23 Nov 2006)
• Surgery with and without the aid of Indocyanine Green (ICG) - Surgical Removal of Idiopathic Epiretinal Membrane With and Without the Assistance of Indocyanine Green. - This study has been completed (Current: 23 Nov 2006)
• Tobradex AF - A Bioequivalence Study of Tobradex AF - This study is currently recruiting patients (Current: 23 Nov 2006)
• Topical Cyclosporine, Tears - Efficacy of Topical Cyclosporine Versus Tears for Improving Visual Outcomes Following Multifocal IOL Implantation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Triamcinolone acetonide - Triamcinolone Vs. Laser for Diabetic Macular Edema - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Vitamin C - Randomized Trials of Vitamin Supplements and Eye Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Vitamin E - Randomized Trials of Vitamin Supplements and Eye Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Vitamin and/or Mineral Supplement - Age-Related Macular Degeneration and Cataract - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Zinc - Age-Related Eye Disease Study (AREDS) - This study is no longer recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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