Clinical Trials for Cerebral Arteriosclerosis

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Cerebral Arteriosclerosis is grouped into the following categories:-

• View by trial name
• View by drugs used in Cerebral Arteriosclerosis clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Cerebral Arteriosclerosis:

• ACCULINK for Revascularization of Carotids in High Risk Patients "The ARCHeR Trial" - This study has been completed (Current: 23 Nov 2006)
• Carotid Stenting vs. Surgery of Severe Carotid Artery Disease and Stroke Prevention in Asymptomatic Patients (ACT I) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Emboshield and Xact Post Approval Carotid Stent Trial (The EXACT Study) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cholesterol-Lowering Atherosclerosis Study (CLAS) - This study has been completed (Current: 23 Nov 2006) - colestipol,niacin
• Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-Up - This study has been suspended (Current: 23 Nov 2006) - Vitamin E,Vitamin C
• Strong Heart Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Epidemiology of Cardiovascular Risk Factors in Women (Healthy Women Study) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Carotid Atherosclerosis Follow-Up Study - This study has been completed (Current: 23 Nov 2006)
• Epidemiology of Carotid Disease in Elderly Adults - This study has been completed (Current: 23 Nov 2006)
• Mechanisms Underlying Psychosocial Associations With Ischemic Heart Disease (Kuopio) - This study has been completed (Current: 23 Nov 2006)
• Postprandial Lipoproteins and Atherosclerosis - This study has been completed (Current: 23 Nov 2006)
• Novel Hemostatic Cardiac Risk Factors in Framingham - This study has been completed (Current: 23 Nov 2006)
• Epidemiology of Carotid Artery Atherosclerosis in Youth - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Risk of Coronary Heart Disease in Women With Polycystic Ovary Syndrome - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Diabetes, Lipoproteins and Accelerated Vascular Disease - This study has been completed (Current: 23 Nov 2006)
• Arterial Endothelial Function--An Epidemiologic Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Early Atherosclerosis Change in Two Clinical Trials - This study has been completed (Current: 23 Nov 2006)
• Prevalence & Progression of Subclinical Atherosclerosis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• VA HDL Intervention Trial (VA-HIT) Ancillary Study Data Analysis - This study has been completed (Current: 23 Nov 2006)
• Epidemiology of Carotid IMT Progression in MESA - Ancillary Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Inflammatory Genomics in Human Carotid Artery Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Effect of Valsartan on Carotid Artery Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Valsartan
• Progression of Sub-Clinical Atherosclerosis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Boston Scientific Embolic Protection, Inc. (EPI): A Carotid Stenting Trial for High-Risk Surgical Patients (BEACH) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Study of Carotid Occlusion and Neurocognition - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Single Center of Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Carotid Artery Stenting With Emboli Protection Surveillance-Post-Marketing Study (CASES-PMS) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Stenting and Angioplasty With Protection in Patients at High Risk for Endarterectomy (SAPPHIRE) - This study has been completed (Current: 23 Nov 2006)
• CAPITAL: Carotid Artery Plaque Intravascular Ultrasound Evaluation - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• CAPTURE 2 Post-Marketing Registry - This study is currently recruiting patients (Current: 23 Nov 2006)
• Asymptomatic Carotid Artery Plaque Study (ACAPS) - This study has been completed (Current: 23 Nov 2006) - aspirin,lovastatin
• Recurrent Carotid Stenosis - This study has been completed (Current: 23 Nov 2006) - aspirin,dipyridamole
• Potential Risk Factors for Stroke - This study has been completed (Current: 23 Nov 2006)
• Comparison of Asymptomatic Carotid Atherosclerosis Between Frequent and Infrequent Blood Donors - This study has been completed (Current: 23 Nov 2006)
• Carotid Revascularization Endarterectomy Versus Stenting Trial (CREST) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Adipose Distribution and Atherosclerosis - This study has been completed (Current: 23 Nov 2006)
• Cohort Study of Heart Rate Variability - This study has been completed (Current: 23 Nov 2006)
• Dietary Antioxidants and Atherosclerosis - This study has been completed (Current: 23 Nov 2006)
• Paraoxonase and LDL Oxidation in Carotid Artery Disease - This study has been completed (Current: 23 Nov 2006) - Paraoxonase
• CARMEDAS: Cost-Effectiveness Analysis of Imaging Strategies in Symptomatic Carotid Stenosis - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Stop Atherosclerosis in Native Diabetics Study - This study has been completed (Current: 23 Nov 2006) - FDA approved drugs to treat blood pressure and cholesterol
• Influence of Pravastatin on Carotid Artery Structure and Function in HIV-Infected Patients Under Antiretroviral Therapy - This study has been completed (Current: 23 Nov 2006)
• A Randomized Trial of Carotid Artery Stenting With and Without Cerebral Protection - This study is currently recruiting patients (Current: 23 Nov 2006)
• Stroke Prevention With Abciximab in Carotid Endarterectomy - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Abciximab
• Post-Approval Study of the Guidant Carotid Stent Systems and Embolic Protection Systems: CAPTURE - This study is currently recruiting patients (Current: 23 Nov 2006)
• EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Atherosclerosis Underlying Development Assessed by Intima-Media Thickness in Patients on Rimonabant (Auditor) - This study has been completed (Current: 23 Nov 2006) - Rimonabant
• To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection - This study is currently recruiting patients (Current: 23 Nov 2006)
• EPIC European Study: Use of the FiberNet Emboli Protection Device in Carotid Artery Stenting - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study of Early Versus Delayed Carotid Endarterectomy (CEA) for Small to Medium-Sized Ischemic Stroke Caused by High-Grade Carotid Stenosis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Carotid Artery Stenting With Protection Registry - This study is currently recruiting patients (Current: 23 Nov 2006)
• The Effects of DexMed and Desflurane on Carotid Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Remifentanyl and Propofol,Dexmedetomidine with Propofol,Remifentanyl with Desflurane,Dexmedetomidine and Desflurane
• EPIC US Feasibility Study: Use of the FiberNet Emboli Protection Device in Carotid Artery Stenting - This study is currently recruiting patients (Current: 23 Nov 2006)
• Carotid Plaque Regression With High Dose Atorvastatin Versus Conventional Dose Simvastatin Using High Field MRI - This study is currently recruiting patients (Current: 23 Nov 2006) - atorvastatin or simvastatin
• Evaluation of the TriActiv ProGuard System During Carotid Artery Stenting - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Randomized, Placebo-Controlled Study of the Effects of Minocycline on Cognitive Function After Carotid Endarterectomy - This study is currently recruiting patients (Current: 23 Nov 2006) - Minocycline
• Radiation Induced Atherosclerosis in Breast Cancer Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Cerebral Arteriosclerosis

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Cerebral Arteriosclerosis:

• Abciximab - Stroke Prevention With Abciximab in Carotid Endarterectomy - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Aspirin - Asymptomatic Carotid Artery Plaque Study (ACAPS) - This study has been completed (Current: 23 Nov 2006)
• Aspirin - Recurrent Carotid Stenosis - This study has been completed (Current: 23 Nov 2006)
• Atorvastatin Or Simvastatin - Carotid Plaque Regression With High Dose Atorvastatin Versus Conventional Dose Simvastatin Using High Field MRI - This study is currently recruiting patients (Current: 23 Nov 2006)
• Colestipol - Cholesterol-Lowering Atherosclerosis Study (CLAS) - This study has been completed (Current: 23 Nov 2006)
• Dexmedetomidine and Desflurane - The Effects of DexMed and Desflurane on Carotid Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Dexmedetomidine with Propofol - The Effects of DexMed and Desflurane on Carotid Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Dipyridamole - Recurrent Carotid Stenosis - This study has been completed (Current: 23 Nov 2006)
• FDA approved drugs to treat blood pressure and cholesterol - Stop Atherosclerosis in Native Diabetics Study - This study has been completed (Current: 23 Nov 2006)
• Lovastatin - Asymptomatic Carotid Artery Plaque Study (ACAPS) - This study has been completed (Current: 23 Nov 2006)
• Minocycline - A Randomized, Placebo-Controlled Study of the Effects of Minocycline on Cognitive Function After Carotid Endarterectomy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Niacin - Cholesterol-Lowering Atherosclerosis Study (CLAS) - This study has been completed (Current: 23 Nov 2006)
• Paraoxonase - Paraoxonase and LDL Oxidation in Carotid Artery Disease - This study has been completed (Current: 23 Nov 2006)
• Remifentanyl and Propofol - The Effects of DexMed and Desflurane on Carotid Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Remifentanyl with Desflurane - The Effects of DexMed and Desflurane on Carotid Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Rimonabant - Atherosclerosis Underlying Development Assessed by Intima-Media Thickness in Patients on Rimonabant (Auditor) - This study has been completed (Current: 23 Nov 2006)
• Valsartan - Effect of Valsartan on Carotid Artery Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Vitamin C - Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-Up - This study has been suspended (Current: 23 Nov 2006)
• Vitamin E - Vitamin E and C to Slow Progression of Common Carotid Artery Plaque Build-Up - This study has been suspended (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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