Causes of Cystic Fibrosis
List of causes of Cystic Fibrosis
Following is a list of causes or underlying conditions
(see also Misdiagnosis of underlying causes of Cystic Fibrosis)
that could possibly cause Cystic Fibrosis includes:
- Genetic mutation. Cystic fibrosis is one of the most common life-shortening genetic diseases
Cystic Fibrosis Causes: Book Excerpts
Cystic Fibrosis as a symptom:
Conditions listing Cystic Fibrosis
as a symptom may also be potential underlying causes of Cystic Fibrosis.
Our database lists the following as having
Cystic Fibrosis as a symptom of that condition:
What causes Cystic Fibrosis?
Causes: Cystic Fibrosis:
CF affects tissues that produce mucus
secretions, such as the airway, the gastrointestinal tract, the ducts of
the pancreas, the bile ducts of the liver and the male urogenital tract.
Normal mucus forms a gel-like barrier that plays an important role in
protecting the cells lining the inside surfaces of these tissues. In the
lung, mucus also transports dust and other particles out of the airway and
helps to prevent infection. CF alters the chemical properties of mucus;
instead of protecting tissues from harm, the abnormal mucus obstructs the
ducts and airways, causing tissue damage.
(Source: excerpt from Cystic Fibrosis Research Directions: NIDDK)
Medical news summaries relating to Cystic Fibrosis:
The following medical news items are relevant to causes of Cystic Fibrosis:
Related information on causes of Cystic Fibrosis:
As with all medical conditions,
there may be many causal factors.
Further relevant information on causes of Cystic Fibrosis may be found in:
Causes of Cystic Fibrosis: Online Medical Books
16 MEDICAL BOOKS ONLINE!
Review excerpts from medical books online, free, without registration,
for more information about the causes of Cystic Fibrosis.
Cystic fibrosis:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
The gene responsible for cystic fibrosis (located on chromosome 7) encodes a protein that involves chloride transport across epithelial membranes; over 100 specific mutations of the gene are known. (See Cystic fibrosis transmission risk.) The immediate causes of symptoms in cystic fibrosis are increased viscosity of bronchial, pancreatic, and other mucous gland secretions and consequent obstruction of glandular ducts. Cystic fibrosis accounts for almost all cases of pancreatic enzyme deficiency in children.
In the United States, the incidence of cystic fibrosis is highest in Whites of northern European ancestry (1 in 2,000 live births) and lowest in Blacks (1 in 17,000 live births), Native Americans, and people of Asian ancestry. The disease occurs equally in both sexes.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Pancreatic cancer:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
Evidence suggests that pancreatic cancer is linked to inhalation or absorption of the following carcinogens, which are then excreted by the pancreas:
❑cigarettes
❑food additives
❑industrial chemicals, such as beta-naphthalene, benzidine, and urea.
Possible predisposing factors are chronic pancreatitis, diabetes mellitus, and chronic alcohol abuse (both pancreatitis and diabetes mellitus may be early manifestations of the disease as well).
Pancreatic cancer incidence increases with age, peaking between ages 60 and 70. Geographically, the incidence is highest in Israel, the United States, Sweden, and Canada.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Cirrhosis and fibrosis:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
These clinical types of cirrhosis reflect its diverse etiology:
❑ Portal, nutritional, or alcoholic (Laennec’s) cirrhosis, the most common type, occurs in 30% to 50% of cirrhotic patients, up to 90% of whom have a history of alcoholism. Liver damage results from malnutrition, especially of dietary protein, and chronic alcohol ingestion. Fibrous tissue forms in portal areas and around central veins.
❑ Biliary cirrhosis (15% to 20% of patients) results from injury or prolonged obstruction.
❑ Postnecrotic (posthepatic) cirrhosis (10% to 30% of patients) stems from various types of hepatitis.
❑ Pigment cirrhosis (5% to 10% of patients) may result from disorders such as hemochromatosis.
❑ Cardiac cirrhosis (rare) refers to liver damage caused by right-sided heart failure.
❑ Idiopathic cirrhosis (about 10% of patients) has no known cause.
Noncirrhotic fibrosis may result from schistosomiasis or congenital hepatic fibrosis or may be idiopathic.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Pancreatitis:
Causes
(Handbook of Diseases)
The most common causes of pancreatitis are biliary tract disease and alcoholism; however, it can also result from pancreatic cancer, trauma, or certain drugs, such as glucocorticoids, sulfonamides, chlorothiazide, azathioprine, excessive use of acetaminophen, and hormonal contraceptives.
This disease may also develop as a complication of peptic ulcer, mumps, or hypothermia. Rarer causes are stenosis or obstruction of the sphincter of Oddi, hypercalcemia, duodenal obstruction, hyperlipemia, ischemia from vasculitis or vascular disease, viral infections, mycoplasmal pneumonia, scorpion venom, and pregnancy. The disease may also be familial or idiopathic.
AGE ALERT: In children, pancreatitis may coincide with abdominal trauma, cystic fibrosis, hemolytic uremic syndrome, Kawasaki disease, mumps, Reye’s syndrome, viral illness, or medications the child may be taking.
Pancreatitis may also develop in a patient after surgery. This occurrence has the highest morbidity and mortality. Whatever the cause, complications from acute pancreatitis are possible.
CLINICAL TIP: Determining the cause of pancreatitis is useful for managing and predicting complications.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Cystic fibrosis:
Causes
(Handbook of Diseases)
Cystic fibrosis is an autosomal recessive disease resulting from mutations in a gene located on chromosome 7. The gene responsible for cystic fibrosis encodes a protein that involves chloride transport across epithelial membranes. The most common mutation in the cystic fibrosis gene involves a deletion resulting in absence of phenylalanine at the cystic fibrosis transmembrane regulator. There have been more than 800 mutations identified to date.
The immediate causes of symptoms are increased viscosity of bronchial, pancreatic, and other mucous gland secretions and consequent obstruction of glandular ducts. Cystic fibrosis accounts for almost all cases of pancreatic enzyme deficiency in children.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Pancreatic cancer:
Causes
(Handbook of Diseases)
Pancreatic cancer, the fourth leading cause of cancer-related death in the United States, is slightly more common in men than in women; risk increases with age. Almost one-third of cases result from cigarette smoking; some cases are related to hereditary syndromes.
Possible predisposing factors are chronic pancreatitis, diabetes mellitus, and chronic alcohol abuse.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
If you're pregnant, there's a chance that your doctor will suggest a procedure known as chorionic villus sampling to determine if your child...
Germs are a fact of life and catching an infectious disease like a cold may seem inevitable. But there are simple ways to protect yourself against...
Sexual contact can sometimes result in problems. An unwanted pregnancy or sexually transmitted diseases may be some of those consequences. But by...
Health insurance is important to everyone, especially people with chronic conditions like Crohn's disease and ulcerative colitis. Tune in to...
See full list of 4 related videos
» Next page: Risk Factors for Cystic Fibrosis
Rate This Website
What do you think about the features of this website?
Take our user survey and have your say:
Website User Survey
Medical Tools & Articles:
Next articles:
Tools & Services:
Medical Articles:
Forums & Message Boards
- Ask or answer a question at the Boards:
