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Prevalence and Incidence of Cystic Fibrosis
Prevalance of Cystic Fibrosis:
1 per 31,000 Asian American newborns suffer from cystic fibrosis in the US, genetics Home Reference website ... see also overview of Cystic Fibrosis.
Prevalance Rate:
approx 1 in 31,000 or 0.00% or 8,774 people in USA [Source statistic for calcuation: "1 per 31,000 Asian American newborns suffer from cystic fibrosis in the US, genetics Home Reference website" -- see also general information about data sources]
Cystic Fibrosis: Rare Disease
Cystic Fibrosis is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Cystic Fibrosis, or a subtype of Cystic Fibrosis, affects less than 200,000 people in the US population.
Ophanet, who are a consortium of European partners, currently defines a condition rare when if affects 1 person per 2,000. They list Cystic Fibrosis as a "rare disease". More information about Cystic Fibrosis is available from Orphanet
Incidence (annual) of Cystic Fibrosis:
2,500 babies annually USA; 1 in 3,000 Caucasian babies ... see also overview of Cystic Fibrosis.
Incidence Rate:
approx 1 in 108,800 or 0.00% or 2,500 people in USA [Source statistic for calcuation: "2,500 babies annually USA; 1 in 3,000 Caucasian babies" -- see also general information about data sources]
Incidence extrapolations for USA for Cystic Fibrosis:
2,500 per year, 208 per month, 48 per week, 6 per day, 0 per hour, 0 per minute, 0 per second. [Source statistic for calculation: "2,500 babies annually USA; 1 in 3,000 Caucasian babies" -- see also general information about data sources]
Prevalance of Cystic Fibrosis:
Every year, 1,000 children with cystic fibrosis (CF) are born in the United States. One in 3,000 Caucasian babies have the disorder, making CF one of the most common lethal genetic diseases in Caucasians. Overall, there are 30,000 Americans with CF, and an estimated 8 million people carry one copy of the defective gene that causes the disease. (Source: excerpt from Cystic Fibrosis Research Directions: NIDDK)
Prevelance of Cystic Fibrosis discussion:
According to the data collected by the Cystic Fibrosis Foundation, there are about 30,000 Americans, 3,000 Canadians, and 20,000 Europeans with CF. The disease occurs mostly in whites whose ancestors came from northern Europe, although it affects all races and ethnic groups. Accordingly, it is less common in African Americans, Native Americans, and Asian Americans. Approximately 2,500 babies are born with CF each year in the United States. Also, about 1 in every 20 Americans is an unaffected carrier of an abnormal "CF gene." These 12 million people are usually unaware that they are carriers. (Source: excerpt from NHLBI, Facts About Cystic Fibrosis: NHLBI)
Prevelance statistics for Cystic Fibrosis:
The following statistics relate to the prevalence of Cystic Fibrosis:
- 8 million genetic carriers in USA (NIDDK)
- About 30,000 people with cystic fibrosis ("Orphan Products: Hope for People With Rare Diseases", By Carol Rados, FDA Consumer magazine, November-December 2003 Issue)
- more statistics...»
Death statistics for Cystic Fibrosis:
The following statistics relate to deaths and Cystic Fibrosis:
- 45 people died from cystic fibrosis in Australia 2000 (Australia’s Health 2004, AIHW)
- more statistics...»
More Statistics about Cystic Fibrosis:
Prevalence/Incidence of Cystic Fibrosis: Online Medical Books
16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the prevalence and/or incidence of Cystic Fibrosis.
Cystic fibrosis:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
The gene responsible for cystic fibrosis (located on chromosome 7) encodes a protein that involves chloride transport across epithelial membranes; over 100 specific mutations of the gene are known. (See Cystic fibrosis transmission risk.) The immediate causes of symptoms in cystic fibrosis are increased viscosity of bronchial, pancreatic, and other mucous gland secretions and consequent obstruction of glandular ducts. Cystic fibrosis accounts for almost all cases of pancreatic enzyme deficiency in children.
In the United States, the incidence of cystic fibrosis is highest in Whites of northern European ancestry (1 in 2,000 live births) and lowest in Blacks (1 in 17,000 live births), Native Americans, and people of Asian ancestry. The disease occurs equally in both sexes.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Pancreatic cancer:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
Evidence suggests that pancreatic cancer is linked to inhalation or absorption of the following carcinogens, which are then excreted by the pancreas:
❑cigarettes
❑food additives
❑industrial chemicals, such as beta-naphthalene, benzidine, and urea.
Possible predisposing factors are chronic pancreatitis, diabetes mellitus, and chronic alcohol abuse (both pancreatitis and diabetes mellitus may be early manifestations of the disease as well).
Pancreatic cancer incidence increases with age, peaking between ages 60 and 70. Geographically, the incidence is highest in Israel, the United States, Sweden, and Canada.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Cirrhosis and fibrosis:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
These clinical types of cirrhosis reflect its diverse etiology:
❑ Portal, nutritional, or alcoholic (Laennec’s) cirrhosis, the most common type, occurs in 30% to 50% of cirrhotic patients, up to 90% of whom have a history of alcoholism. Liver damage results from malnutrition, especially of dietary protein, and chronic alcohol ingestion. Fibrous tissue forms in portal areas and around central veins.
❑ Biliary cirrhosis (15% to 20% of patients) results from injury or prolonged obstruction.
❑ Postnecrotic (posthepatic) cirrhosis (10% to 30% of patients) stems from various types of hepatitis.
❑ Pigment cirrhosis (5% to 10% of patients) may result from disorders such as hemochromatosis.
❑ Cardiac cirrhosis (rare) refers to liver damage caused by right-sided heart failure.
❑ Idiopathic cirrhosis (about 10% of patients) has no known cause.
Noncirrhotic fibrosis may result from schistosomiasis or congenital hepatic fibrosis or may be idiopathic.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Cystic Fibrosis:
Cystic Fibrosis - epidemiology
(The 5-Minute Pediatric Consult)
- Most common lethal inherited disease in the Caucasian population
- Carrier frequency of mutations in the CF transmembrane conductance regulator (CFTR) gene:
- 1:29 in Caucasians
- 1:49 in Hispanics
- 1:53 in Native Americans
- 1:62 in African Americans
- 1:90 in Asians
Cystic Fibrosis - incidence
- 1:3,300 in Caucasians
- 1:9,500 in Hispanics
- 1:11,200 in Native Americans
- 1:15,300 in African Americans
- 1:32,100 in Asians
Source: The 5-Minute Pediatric Consult, 2008
About prevalence and incidence statistics:
The term 'prevalence' of Cystic Fibrosis usually refers to the estimated population of people who are managing Cystic Fibrosis at any given time. The term 'incidence' of Cystic Fibrosis refers to the annual diagnosis rate, or the number of new cases of Cystic Fibrosis diagnosed each year. Hence, these two statistics types can differ: a short-lived disease like flu can have high annual incidence but low prevalence, but a life-long disease like diabetes has a low annual incidence but high prevalence. For more information see about prevalence and incidence statistics.
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