Causes: Chronic Granulomatous Disease:
Patients with CGD have poorly-functioning
phagocytes caused by mutations in one of four different genes. The
abnormal genes cannot make proteins required for the production of
oxygen byproducts, such as hydrogen peroxide and superoxide, which
kill bacteria and fungi. (Source: excerpt from Primary Immune Deficiency, NIAID Fact Sheet: NIAID)
As with all medical conditions, there may be many causal factors. Further relevant information on causes of Chronic Granulomatous Disease may be found in:
16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the causes of Chronic Granulomatous Disease.
CGD is inherited as a recessive X-linked trait in 50% to 60% of affected patients. Males are more likely to be affected. The genetic defect may be linked to deficiency of the enzyme NADH, NADPH oxidase, or NADH reductase. The inability of phagocytic cells to kill certain bacteria and fungi leads to long-term and repeated infections.
Source: Professional Guide to Diseases (Eighth Edition), 2005
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