Chronic Granulomatous Disease

Introduction: Chronic Granulomatous Disease

Chronic Granulomatous Disease: The CGD patient's defense system is not effective against certain bacteria and fungi, including E. coli and Staphylococcus ... more about Chronic Granulomatous Disease.

Chronic Granulomatous Disease: A very rare inherited blood disorder where certain cells involved with immunity (phagocytes) are unable to destroy bacteria and hence the patient suffers repeated bacterial infections. More detailed information about the symptoms, causes, and treatments of Chronic Granulomatous Disease is available below.

Symptoms of Chronic Granulomatous Disease

• Fevers
• Skin rashes
• Persistent cough
• Boils
• Gum disease

See full list of 31 symptoms of Chronic Granulomatous Disease

Medical Textbooks Online about Chronic Granulomatous Disease

Book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.

Diagnostic Tests for Chronic Granulomatous Disease

• CBC
• Immune function blood tests
• Immunoglobulins level - usually elevated.
• Chest x-rays - these may show granulomas
• Erythrocyte sedimentation rate (ESR)

See full list of 6 diagnostic tests for Chronic Granulomatous Disease

Wrongly Diagnosed with Chronic Granulomatous Disease?

• Misdiagnosis of Chronic Granulomatous Disease

Causes of Chronic Granulomatous Disease

Read more about causes of Chronic Granulomatous Disease.

Treatments for Chronic Granulomatous Disease

• Antibiotics - for infections; usually high-doses
• Preventive oral antibiotics
• Trimethoprim/sulfamethoxazole combination
• Surgical abscess drainage
• Steroids - for gastrointestinal or urinary obstructions.

See full list of 8 treatments for Chronic Granulomatous Disease

Videos for Chronic Granulomatous Disease

Patient Surveys for Chronic Granulomatous Disease

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Reseach about Chronic Granulomatous Disease

Visit our research pages for current research about Chronic Granulomatous Disease treatments.

Clinical Trials for Chronic Granulomatous Disease

The US based website ClinicalTrials.gov lists information on both federally and privately supported clinical trials using human volunteers.

Some of the clinical trials listed on ClinicalTrials.gov for Chronic Granulomatous Disease include:

• Treatment of Chronic Granulomatous Disease With Allogeneic Stem Cell Transplantation Versus Standard of Care - This study has been completed (Current: 23 Nov 2006) - T-Cell Depleted & CD34+Select/w/StemCell Enriched Product
• A Phase IV Study of Recombinant Human Gamma Interferon in Patients With Chronic Granulomatous Diseases of Childhood - This study has been completed (Current: 23 Nov 2006)
• Use of G-CSF to Obtain Blood Cell Precursors - This study is currently recruiting patients (Current: 23 Nov 2006)
• Gene Therapy for Chronic Granulomatous Diseases - Long-Term Follow-up - This study is no longer recruiting patients (Current: 23 Nov 2006) - Gene Therapy Method for CGD
• Stem Cell Transplant Following Low-Intensity Chemotherapy to Treat Chronic Granulomatous Disease - This study has been completed (Current: 23 Nov 2006)

See full list of 17 Clinical Trials for Chronic Granulomatous Disease

Statistics for Chronic Granulomatous Disease

• Medical statistics for Chronic Granulomatous Disease
• Prevalence and incidence statistics for Chronic Granulomatous Disease
• Death and Mortality statistics for Chronic Granulomatous Disease
• Society statistics for Chronic Granulomatous Disease

Types of Chronic Granulomatous Disease

• Autosomal recessive CGD
• X-linked CGD

Read more about Types of Chronic Granulomatous Disease

Stories from Users Related to Chronic Granulomatous Disease

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Article Excerpts about Chronic Granulomatous Disease

The CGD patient's defense system is not effective against certain bacteria and fungi, including E. coli and Staphylococcus aureus, as well as less common germs like Pseudomonas, Serratia, and Aspergillus. (Source: excerpt from Primary Immune Deficiency, NIAID Fact Sheet: NIAID)

Definitions of Chronic Granulomatous Disease:

A recessive X-linked defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. - (Source - Diseases Database)

Chronic Granulomatous Disease is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Chronic Granulomatous Disease, or a subtype of Chronic Granulomatous Disease, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Chronic Granulomatous Disease as a "rare disease".
Source - Orphanet