The list of treatments mentioned in various sources for Chronic Granulomatous Disease includes the following list. Always seek professional medical advice about any treatment or change in treatment plans.
The first step in getting correct treatment is to get a correct diagnosis. Differential diagnosis list for Chronic Granulomatous Disease may include:
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Early, aggressive treatment of infection is the chief goal in caring for a patient with CGD. Areas of suspected infection should be biopsied or cultured, and broad-spectrum antibiotics are usually started immediately — without waiting for results of cultures. Confirmed abscesses may be drained or surgically removed. Provide meticulous wound care after such treatment, including irrigation or packing.
Many patients with CGD receive a combination of I.V. antibiotics, in many cases extended beyond the usual 10- to 14-day course. However, for fungal infections with Aspergillus or Nocardia, treatment involves amphotericin B in gradually increasing doses to achieve a maximum cumulative dose. During I.V. drug therapy, monitor vital signs frequently and rotate the I.V. site every 48 to 72 hours.
To help treat antibiotic-resistant or life-threatening infection, or to help localize infection, the patient may receive granulocyte transfusions — usually once daily until the crisis has passed. During such transfusions, watch for fever and chills (these effects can sometimes be prevented by premedication with acetaminophen). Transfusions shouldn’t be given for 6 hours before or after amphotericin B to avoid severe pulmonary edema and, possibly, respiratory arrest.
Interferon-gamma may help reduce the number of severe infections. Bone marrow transplantation is also promising.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Antimicrobials to treat underlying cause, I.V. fluid replacement, colloid or crystalloid infusions, diuretics, vasopressors, removal and replacement of invasive devices
Source: Professional Guide to Diseases (Eighth Edition), 2005
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