Diseases » Chronic liver disease

Hepatomegaly

Hepatomegaly: Excerpt from A Pocket Manual of Differential Diagnosis

Palpable Liver without Hepatic Pathology

Normal variant
Thin or flaccid abdominal wall
Depressed right diaphragm (e.g., emphysema)
Subdiaphragmatic lesion (e.g., abscess)
Riedel's lobe

True Hepatic Enlargement

Inflammatory liver disease
   Hepatitis
       Infectious
          Viral
          Schistosomiasis
          Other
       Alcoholic
       Other toxins
       Drug-induced
       Autoimmune
       Steatohepatitis
       Steatosis
       Other
   Abscess
       Pyogenic
       Amebic
   Cholangitis
       Suppurative
       Sclerosing
   Pericholangitis (especially related to ulcerative colitis)
Chronic liver disease, cirrhosis
   Alcoholic
   Posthepatitic
   Postnecrotic
   Cholestatic
Metabolic disorders
   Hemochromatosis
Alpha₁-antitrypsin deficiency
   Wilson's disease
   Cystic fibrosis
Other causes
   Extrahepatic biliary obstruction
       Choledocholithiasis
       Biliary stricture
       Pancreatitis
       Carcinoma
          Bile ducts (cholangiocarcinoma)
          Head of pancreas
          Ampulla of Vater
       External compression
   Hepatic congestion
       Congestive heart failure
       Constrictive pericarditis
       Budd-Chiari syndrome (hepatic outflow obstruction)
          Thrombosis
          Tumor
          Web (inferior vena cava)
   Veno-occlusive disease
       Jamaican herbal tea
       After bone-marrow transplantation
   Infiltrative disorders, storage diseases
       Lipid accumulation
          Fatty liver
              Alcohol
              Diabetes mellitus
              Obesity
              Severe protein malnutrition
              Nonalcoholic steatohepatitis
              Jejunoileal bypass
              Parenteral hyperalimentation
              Corticosteroids, Cushing's syndrome
              Fatty liver of pregnancy
              Massive tetracycline therapy
              Toxins (e.g., carbon tetrachloride,   
  dichlorodiphenyl-trichloroethane)
              Reye's syndrome
          Lipid storage disease (especially Gaucher's disease, Niemann-Pick disease)
       Glycogen accumulation
          Glycogen storage disease
          Diabetic glycogenosis
       Granulomatous infiltration (especially sarcoidosis, miliary tuberculosis, disseminated fungal diseases, some drug reactions)
       Myelo- and lymphoproliferative disorders
          Lymphoma
          Myeloid metaplasia
          Multiple myeloma
          Leukemia
       Amyloidosis
       Congenital hepatic fibrosis
       Hemochromatosis
       Wilson's disease
   Alpha₁-antitrypsin deficiency
       Hurler's syndrome
   Neoplasms
       Primary
          Malignant
              Hepatocellular carcinoma
              Cholangiocarcinoma
              Angiosarcoma
          Benign
              Hepatic adenoma
              Hemangioma
              Focal nodular hyperplasia
              Adenoma
       Metastatic
          Pancreas
          Colon
          Lung
          Breast
          Stomach
          Kidney
          Esophagus
          Carcinoid
   Cysts
       Congenital
          Solitary
          Polycystic
       Acquired (especially echinococcal)

Book Source Details

• Book Title: A Pocket Manual of Differential Diagnosis
• Author(s): Stephen N. Adler, Dianne B. Gasbarra
• Year of Publication: 1999
• Copyright Details: A Pocket Manual of Differential Diagnosis, Copyright © 1999 Lippincott Williams & Wilkins.

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Copyright notice for book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.

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More About This Book: Title: A Pocket Manual of Differential Diagnosis Authors: Stephen N. Adler, Dianne B. Gasbarra Publisher: Lippincott Williams & Wilkins Copyright: 1999 ISBN: 0-78171-943-7

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