Causes of Common Variable Immunodeficiency
Common Variable Immunodeficiency Causes: Book Excerpts
Common Variable Immunodeficiency as a symptom:
Conditions listing Common Variable Immunodeficiency
as a symptom may also be potential underlying causes of Common Variable Immunodeficiency.
Our database lists the following as having
Common Variable Immunodeficiency as a symptom of that condition:
What causes Common Variable Immunodeficiency?
Causes: Common Variable Immunodeficiency:
Unknown. Probably not genetic as no clear inheritance patterns.
CVI has no clear pattern of inheritance.
The cause is unknown. (Source: excerpt from Primary Immune Deficiency, NIAID Fact Sheet: NIAID)
Related information on causes of Common Variable Immunodeficiency:
As with all medical conditions,
there may be many causal factors.
Further relevant information on causes of Common Variable Immunodeficiency may be found in:
Causes of Common Variable Immunodeficiency: Online Medical Books
16 MEDICAL BOOKS ONLINE!
Review excerpts from medical books online, free, without registration,
for more information about the causes of Common Variable Immunodeficiency.
Hearing Loss – Acquired:
Differential Diagnosis
(In A Page: Pediatric Signs and Symptoms)
Conductive (CHL)
-
Cerumen impaction
-
External auditory canal foreign body
-
Middle ear effusion (MEE)
–Frequently follows acute otitis media
-
Tympanic membrane (TM) perforation
–Usually due to trauma, chronic otitis media
-
Cholesteatoma
–Acquired cholesteatoma is accompanied by TM retraction or perforation
–Congenital cholesteatoma is usually over an intact TM
-
Ossicular erosion or fixation due to middle ear disease
-
Ossicular chain discontinuity (generally posttraumatic)
-
External auditory canal stenosis from chronic otitis externa
-
Middle ear tumor
–Paraganglioma (glomus tympanicum), facial neuroma, histiocytosis X, etc.
Sensorineural (SNHL)
-
Meningitis, especially bacterial
-
Viral, especially mumps
-
Autoimmune disease
–Vasculitis, scleroderma, Kawasaki disease
–Idiopathic
-
Acoustic trauma (noise-induced)
-
Ototoxic medications
–Aminoglycosides
–Diuretics (especially loop diuretics)
–Salicylates
–Cytotoxic (chemotherapeutic) agents, e.g., cisplatinum
-
Temporal bone fracture
–SNHL more likely with transverse than longitudinal fracture
-
Perilymphatic fistula (PLF)
–Hearing loss may be progressive or
fluctuating
- Cerebellopontine angle (CPA) tumor
–Vestibular schwannoma (a.k.a. acoustic neuroma, associated with type II neurofibromatosis), meningioma, etc.
–SNHL will be unilateral - Ménière disease
–Characterized by hearing loss, vertigo, tinnitus, sensation of aural fullness
» READ BOOK EXCERPT ONLINE »
Source: In A Page: Pediatric Signs and Symptoms, 2007
Common variable immunodeficiency:
Causes
(Professional Guide to Diseases (Eighth Edition))
The cause of common variable immunodeficiency is unknown. Most patients have a normal circulating B-cell count but defective synthesis or release of immunoglobulins. Many also exhibit progressive deterioration of T-cell (cell-mediated) immunity revealed by delayed hypersensitivity skin testing.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
X-linked infantile hypogammaglobulinemia:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
In this disease, B cells and B-cell precursors may be present in the bone marrow and peripheral blood, but a mutation in the B-cell protein tyrosine kinase causes failure of the B cells to mature and to secrete immunoglobulin. In the absence of protective immunoglobulins, the affected individual develops repeated infections. Worldwide, malnutrition is the primary cause of antibody disorders.
Humoral immune deficiencies account for 50% of all primary immunodeficiencies. IgA deficiency is the most common antibody deficiency symdrome, followed by common variable immunodeficiency (CVID). The incidence of these two disorders is 1 in 700 persons.Selective IgM deficiency is rare. IgG4 deficiency occurs in 10% to 15% of the population.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Common variable immunodeficiency:
Causes
(Handbook of Diseases)
Exactly what causes common variable immunodeficiency is unknown. Most patients have a normal circulating B-cell count but defective synthesis or release of immunoglobulins. Many also exhibit progressive deterioration of T-cell (cell-mediated) immunity, which is revealed by delayed hypersensitivity skin testing.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Chronic fatigue and immune dysfunction syndrome:
Causes
(Handbook of Diseases)
Although the cause of CFIDS is unknown, researchers suspect that it may be found in human herpesvirus 6 or in other herpesviruses, enteroviruses, or retroviruses. Rising levels of antibodies to EBV, once thought to implicate EBV infection as the cause of CFIDS, are now considered a result of this disease.
CFIDS may be associated with a reaction to viral illness that’s complicated by dysfunctional immune response and by other factors that may include sex, age, genetic disposition, prior illness, stress, and environment.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
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