Prevalence and Incidence of Common Variable Immunodeficiency
Common Variable Immunodeficiency: Rare Disease
Common Variable Immunodeficiency is listed as a "rare disease" by the Office of
Rare Diseases (ORD) of the National Institutes of Health
(NIH). This means that Common Variable Immunodeficiency, or a subtype of Common Variable Immunodeficiency,
affects less than 200,000 people in the US population.
Ophanet, who are a consortium of European partners,
currently defines a condition rare when if affects 1 person per 2,000.
They list Common Variable Immunodeficiency as a "rare disease".
More information about Common Variable Immunodeficiency is available from Orphanet
Common Variable Immunodeficiency Prevalence: Book Excerpts
Prevalence/Incidence of Common Variable Immunodeficiency: Online Medical Books
16 MEDICAL BOOKS ONLINE!
Review excerpts from medical books online, free, without registration,
for more information about the prevalence and/or incidence of Common Variable Immunodeficiency.
X-linked infantile hypogammaglobulinemia:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
In this disease, B cells and B-cell precursors may be present in the bone marrow and peripheral blood, but a mutation in the B-cell protein tyrosine kinase causes failure of the B cells to mature and to secrete immunoglobulin. In the absence of protective immunoglobulins, the affected individual develops repeated infections. Worldwide, malnutrition is the primary cause of antibody disorders.
Humoral immune deficiencies account for 50% of all primary immunodeficiencies. IgA deficiency is the most common antibody deficiency symdrome, followed by common variable immunodeficiency (CVID). The incidence of these two disorders is 1 in 700 persons.Selective IgM deficiency is rare. IgG4 deficiency occurs in 10% to 15% of the population.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Common Variable Immunodeficiency:
Common Variable Immunodeficiency - epidemiology
(The 5-Minute Pediatric Consult)
- Incidence is estimated to be 1 in 25,000 to 1 in 66,000 in the general population.
- Can present at any age, but usually seen in the 2nd–3rd decade of life. Common variable immunodeficiency has been described in patients as young as 6 months.
- Diagnosis is usually made several years after the onset of recurrent infections (pneumonia, sinusitis, otitis).
- A subgroup of children has been described in which the onset of disease was most often <5 years of age. This group was characterized by a relapsing and remitting course in which autoimmune disease predominated.
- About 20%–25% of patients with common variable immunodeficiency have one or more autoimmune conditions at the time of diagnosis.
- Affects males and females equally.
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» READ BOOK EXCERPT ONLINE »
Source: The 5-Minute Pediatric Consult, 2008
Immunoglobulin A Deficiency:
Immunoglobulin A Deficiency - epidemiology
(The 5-Minute Pediatric Consult)
Prevalence is ~1 in 500 in the normal population.
» READ BOOK EXCERPT ONLINE »
Source: The 5-Minute Pediatric Consult, 2008
Acquired Hypothyroidism:
Acquired Hypothyroidism - epidemiology
(The 5-Minute Pediatric Consult)
Acquired Hypothyroidism - incidence
- May develop at any age
- Autoimmune thyroid disorders occur more frequently in children and adolescents with type 1 diabetes mellitus.
Acquired Hypothyroidism - prevalence
Chronic lymphocytic thyroiditis prevalence correlates with iodine intake; countries with the highest dietary iodine also have the highest prevalence.
» READ BOOK EXCERPT ONLINE »
Source: The 5-Minute Pediatric Consult, 2008
About prevalence and incidence statistics:
The term 'prevalence' of Common Variable Immunodeficiency usually refers to the estimated population
of people who are managing Common Variable Immunodeficiency at any given time.
The term 'incidence' of Common Variable Immunodeficiency refers to the annual diagnosis rate,
or the number of new cases of Common Variable Immunodeficiency diagnosed each year.
Hence, these two statistics types can differ:
a short-lived disease like flu can have high annual incidence but low prevalence,
but a life-long disease like diabetes has a low annual incidence but high prevalence.
For more information see about prevalence and incidence statistics.
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