Symptoms of Congenital syphilis
Symptoms of Congenital syphilis
The list of signs and symptoms mentioned in various sources
for Congenital syphilis includes the 28
symptoms listed below:
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Congenital syphilis: Complications
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Congenital syphilis Symptoms: Book Excerpts
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Congenital syphilis: Undiagnosed Conditions
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Other Possible Causes of these Symptoms
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of other causes including diseases, medical conditions, toxins, drug interactions,
or drug side effect causes of that symptom.
Medical Books Online about Congenital syphilis
Medical Books Excerpts
Excerpts of published medical book chapters related to Congenital syphilis
are available from published medical books
for more detailed information about Congenital syphilis.
Medical Books Excerpts
- Syphilis
- "Professional Guide to Diseases (Eighth Edition)" (2005)
- [ read ]
Copyright notice for book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.
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Symptoms of Congenital syphilis: Online Medical Books
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Syphilis:
Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))
Primary syphilis develops after an incubation period that generally lasts about 3 weeks. Initially, one or more chancres (small, fluid-filled lesions) erupt on the genitalia; others may erupt on the anus, fingers, lips, tongue, nipples, tonsils, or eyelids. These chancres, which are usually painless, start as papules and then erode; they have indurated, raised edges and clear bases. Chancres typically disappear after 3 to 6 weeks, even when untreated. They’re usually associated with regional lymphadenopathy (unilateral or bilateral). In females, chancres are commonly overlooked because they usually develop on internal structures — the cervix or the vaginal wall.
The development of symmetrical mucocutaneous lesions and general lymphadenopathy signals the onset of secondary syphilis, which may develop within a few days or up to 8 weeks after onset of initial chancres. The rash of secondary syphilis can be macular, papular, pustular, or nodular. Lesions are of uniform size, well defined, and generalized. Macules typically erupt between rolls of fat on the trunk and, proximally, on the arms, palms, soles, face, and scalp. In warm, moist areas (perineum, scrotum, vulva, and between rolls of fat), the lesions enlarge and erode, producing highly contagious, pink or grayish white lesions (condylomata lata).
Mild constitutional symptoms of syphilis appear in the second stage and may include headache, malaise, anorexia, weight loss, nausea, vomiting, sore throat and, possibly, slight fever. Alopecia may occur, with or without treatment, and is usually temporary. Nails become brittle and pitted.
Latent syphilis is characterized by an absence of clinical symptoms but a reactive serologic test for syphilis. Because infectious mucocutaneous lesions may reappear when infection is of less than 4 years’duration, early latent syphilis is considered contagious. Approximately two-thirds of patients remain asymptomatic in the late latent stage; the rest develop characteristic late-stage symptoms.
Late syphilis is the final, destructive but noninfectious stage of the disease. It has three subtypes, any or all of which may affect the patient: late benign syphilis, cardiovascular syphilis, and neurosyphilis. The lesions of late benign syphilis develop on the skin, bones, mucous membranes, upper respiratory tract, liver, or stomach between 1 and 10 years after infection. The typical lesion is a gumma — a chronic, superficial nodule or deep, granulomatous lesion that’s solitary, asymmetrical, painless, and indurated. Gummas can be found on any bone — particularly the long bones of the legs — and in any organ. If late syphilis involves the liver, it can cause epigastric pain, tenderness, enlarged spleen, and anemia; if it involves the upper respiratory tract, it can cause perforation of the nasal septum or the palate. In severe cases, late benign syphilis results in destruction of bones or organs, which eventually causes death.
Cardiovascular syphilis develops about 10 years after the initial infection in approximately 10% of patients with late, untreated syphilis. It causes fibrosis of elastic tissue of the aorta and leads to aortitis, usually in the ascending and transverse sections of the aortic arch. Cardiovascular syphilis may be asymptomatic or may cause aortic insufficiency or aneurysm.
Symptoms of neurosyphilis develop in about 8% of patients with late, untreated syphilis and appear from 5 to 35 years after infection. These clinical effects consist of meningitis and widespread central nervous system damage that may include general paresis, personality changes, and arm and leg weakness.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Syphilis:
Signs and symptoms
(Handbook of Diseases)
Each stage produces distinctive signs and symptoms.
Primary syphilis
After an incubation period that generally lasts about 3 weeks, symptoms of primary syphilis develop.
Initially, one or more chancres (small, fluid-filled lesions) erupt on the genitalia; others may erupt on the anus, fingers, lips, tongue, nipples, tonsils, or eyelids. These chancres, which are usually painless, start as papules and then erode; they have indurated, raised edges and clear bases.
Chancres typically disappear after 3 to 6 weeks, even when untreated. They are usually associated with regional lymphadenopathy (unilateral or bilateral). In women, chancres are frequently overlooked because they often develop on internal structures — the cervix or the vaginal wall.
Secondary syphilis
The development of symmetrical mucocutaneous lesions and general lymphadenopathy signals the onset of secondary syphilis, which may develop within a few days or up to 8 weeks after the onset of initial chancres.
The rash of secondary syphilis can be macular, papular, pustular, or nodular. Lesions are of uniform size, well defined, and generalized. Macules often erupt between rolls of fat on the trunk and on the arms, palms, soles, face, and scalp. In warm, moist areas (perineum, scrotum, vulva, between rolls of fat), the lesions enlarge and erode, producing highly contagious, pink or grayish white lesions (condylomata lata). Even without treatment, rashes clear up on their own.
Mild constitutional symptoms of syphilis appear in the second stage and may include headache, malaise, anorexia, weight loss, nausea, vomiting, sore throat and, possibly, slight fever. Alopecia may occur, with or without treatment, and is usually temporary. Nails become brittle and pitted.
Latent syphilis
Although no clinical symptoms occur in latent syphilis, it produces a reactive serologic test for syphilis. Because infectious mucocutaneous lesions may reappear when infection is of less than 4 years’duration, early latent syphilis is considered contagious.
Approximately two-thirds of patients remain asymptomatic in the late latent stage until death. The rest develop characteristic late-stage symptoms.
Late syphilis
The final, destructive, but noninfectious stage of the disease, late syphilis has three subtypes, any or all of which may affect the patient: late benign syphilis, cardiovascular syphilis, and neurosyphilis.
The lesions of late benign syphilis develop between 1 and 10 years after infection. They may appear on the skin, bones, mucous membranes, upper respiratory tract, liver, or stomach.
The typical lesion is a gumma — a chronic, superficial nodule or deep, granulomatous lesion that’s solitary, asymmetrical, painless, and indurated. Gummas can be found on any bone, particularly the long bones of the legs, and in any organ.
If late syphilis involves the liver, it can cause epigastric pain, tenderness, enlarged spleen, and anemia; if it involves the upper respiratory tract, it may cause perforation of the nasal septum or the palate. In severe cases, late benign syphilis results in destruction of bones or organs, which eventually causes death.
Cardiovascular syphilis develops about 10 years after the initial infection in approximately 10% of patients with late, untreated syphilis. It causes fibrosis of elastic tissue of the aorta and leads to aortitis, most often in the ascending and transverse sections of the aortic arch. Cardiovascular syphilis may be asymptomatic or may cause aortic regurgitation or aneurysm.
Symptoms of neurosyphilis develop in about 8% of patients with late, untreated syphilis and appear from 5 to 35 years after infection. These clinical effects consist of meningitis and widespread central nervous system damage that may include general paresis, personality changes, and arm and leg weakness.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Syphilis:
Syphilis - signs & symptoms
(The 5-Minute Pediatric Consult)
- Congenital syphilis:
- Clinical manifestations range from asymptomatic to death or stillbirth.
- Clinical signs include periostitis, osteochondritis, persistent rhinorrhea, or maculopapular rash.
- Acquired syphilis:
- Primary stage: Painless, indurated ulcers (chancres), single or multiple, at the site of inoculation ~3 weeks after exposure (range 10–90 days); lesions usually resolve without treatment in 3–6 weeks.
- Secondary stage: Generalized rash, which is often maculopapular and involves the palms and soles; condyloma lata, hypertrophic papular lesions; fever, malaise, lymphadenopathy; signs appear 3–6 weeks after initial chancre and may last 2–10 weeks
- Relapse: Symptoms of secondary syphilis may recur 1 or more times before the latent period.
- Latent period: Untreated, illness may enter a latent stage; patients are asymptomatic, not contagious; lasts 1–40 years or more; patients seroreactive but without other evidence of disease.
- Early latent period: 1st 4 years of latent period
- Late latent period: Subsequent years
- Tertiary stage: Up to 1/3 of untreated secondary syphilis cases progress to tertiary or late disease; can occur many years after the primary infection; may see gummatous changes of the skin, bone, and/or viscera, or cardiovascular syphilis
- Neurosyphilis: CNS involvement in 3–7% of untreated cases; can develop at any stage of disease; signs include changes in mood/behavior, hyperactive reflexes, impaired memory and/or judgment, and Argyll–Robertson pupils
» READ BOOK EXCERPT ONLINE »
Source: The 5-Minute Pediatric Consult, 2008
Congenital Infections:
Presentation
(Pediatric Infectious Disease)
Ten percent of infants with congenital CMV infection are symptomatic at birth.
These patients often present with multiple organ system involvement, including
intrauterine growth retardation, petechiae, anemia, leukopenia, and
thrombocytopenia. A classic finding on computed tomography of the head in
congenital CMV is periventricular calcification (Fig. 3.1). The predilection
for the calcification in this area is believed to be related to the tendency of
CMV to infect the rapidly dividing germinal matrix cells. Magnetic resonance
imaging of neonates with congenital CMV infection may also reveal irregular
areas in the junction of the gray and white matter, accompanied by the presence
of ventricular pseudocysts. Patients with congenital CMV may have continual
neurologic damage even after birth, which is thought to be secondary to
persistent viral replication.
» READ BOOK EXCERPT ONLINE »
Source: Pediatric Infectious Disease, 2004
Congenital syphilis as a Cause of Symptoms or Medical Conditions
When considering symptoms of Congenital syphilis, it is also important to consider Congenital syphilis as a possible cause of other medical conditions.
The Disease Database lists the following medical conditions that Congenital syphilis may cause:
- (Source - Diseases Database)
Medical articles and books on symptoms:
These general reference articles may be of interest
in relation to medical signs and symptoms of disease in general:
Full list of premium articles on symptoms and diagnosis
About signs and symptoms of Congenital syphilis:
The symptom information on this page
attempts to provide a list of some possible signs and symptoms of Congenital syphilis.
This signs and symptoms information for Congenital syphilis has been gathered from various sources,
may not be fully accurate,
and may not be the full list of Congenital syphilis signs or Congenital syphilis symptoms.
Furthermore, signs and symptoms of Congenital syphilis may vary on an individual basis for each patient.
Only your doctor can provide adequate diagnosis of any signs or symptoms and whether they
are indeed Congenital syphilis symptoms.
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» Next page: Diagnostic Tests for Congenital syphilis
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