Cure Research for Connective tissue disorders
Cure Research discussion for Connective tissue disorders:
Questions and Answers about Heritable Disorders of Connective Tissue: NIAMS (Excerpt)
The NIAMS is conducting an in-depth natural history study of
people who have Marfan syndrome (which leads to abnormally long
bones), nail-patella syndrome (a congenital skeletal disorder),
Stickler syndrome (which causes eye and joint problems), and
Ehlers-Danlos syndrome (which causes skin and blood vessel problems).
All of these disorders have multiple, interrelated symptoms. NIAMS
scientists are studying these people closely and over a long period to
get a more complete picture of the diseases. They hope to improve
their understanding of the genetic origins of the symptoms, of disease
progression, and of mutations in patients and their relatives.
Scientists expect their findings to apply to other HDCTs as well.
(Source: excerpt from Questions and Answers about Heritable Disorders of Connective Tissue: NIAMS)
Questions and Answers about Heritable Disorders of Connective Tissue: NIAMS (Excerpt)
Other NIAMS researchers are exploring
- the chemistry and biology of elastin genes
- collagen gene defects (several types) that cause bone
diseases
- collagen IV gene defects in mice and in humans (Alport
syndrome)
- proteoglycans, a group of proteins that maintain tissue
stiffness
- fibroblasts, cells that form the fibrous tissues in the
body
- cartilage, joints, and skin layers.
Ongoing studies of aneurysms--a weak spot in a blood
vessel wall that threatens to burst--are taking place at several NIH
Institutes. Aneurysms can prove deadly to people with Marfan syndrome
and other HDCTs. These studies have been helped by a pioneering project
at the NIAMS that developed a breed of mice prone to aneurysms.
Scientists hope the mutant mice will improve understanding of aneurysms
and ways to prevent them.
(Source: excerpt from Questions and Answers about Heritable Disorders of Connective Tissue: NIAMS)
Clinical Trials for Connective tissue disorders
Some of the clinical trials for Connective tissue disorders include:
Evidence Based Medicine Research for Connective tissue disorders
Medical research papers related to Connective tissue disorders include:
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Statistics about Connective tissue disorders
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