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Diseases » Constipation » Clinical Trials

Clinical Trials for Constipation

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Constipation is grouped into the following categories:-

View by trial name

View by drugs used in Constipation clinical trials

Clinical Trials by trial name

The format for each of the following is:

The name of the trial,
followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.
followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Constipation:

Phase 2 Study of MD-1100 Acetate Administered for 14 Days to Patients Meeting Criteria for Chronic Constipation - This study is currently recruiting patients (Current: 23 Nov 2006) - MD-1100 Acetate
Dose-Range-Finding, Phase 2 Trial of Oral Linaclotide Acetate Administered to Patients With Chronic Constipation - This study is currently recruiting patients (Current: 23 Nov 2006) - linaclotide acetate
Constipation in Pediatric Cancer Patients Receiving Vinca Alkaloids or Narcotics - This study has been completed (Current: 23 Nov 2006)
Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain Medication - This study is currently recruiting patients (Current: 23 Nov 2006) - alvimopan
Biofeedback for Dyssynergic Constipation - This study is no longer recruiting patients (Current: 23 Nov 2006) - Diazepam
Preference of Tegaserod Vs. PEG 3350 in Patients With Constipation - This study is no longer recruiting patients (Current: 23 Nov 2006) - Tegaserod and Polyethylene Glycol 3350
Diagnosis of Functional Defecation Disorders in Childhood - This study is currently recruiting patients (Current: 23 Nov 2006)
Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain - This study is no longer recruiting patients (Current: 23 Nov 2006) - alvimopan
Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain - This study is no longer recruiting patients (Current: 23 Nov 2006) - alvimopan
Alvimopan For The Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain - This study is no longer recruiting patients (Current: 23 Nov 2006) - alvimopan
Treatment of Fecal Incontinence and Constipation in Patients With Spinal Cord Injury - This study has been completed (Current: 23 Nov 2006)
Effectiveness Study of Chinese Herbal Medicine for Functional Constipation - This study is currently recruiting patients (Current: 23 Nov 2006) - Ma Zi Ren Wan
A Pilot Study of a New MiraLax Dose Formulation For Use in Constipated Children - This study has been completed (Current: 23 Nov 2006) - MiraLax
Clinical Evaluation Of Alvimopan (SB767905) On Constipation And Related Symptoms Associated With Opioid - This study is currently recruiting patients (Current: 23 Nov 2006) - SB767905
A Colonic Tube to Improve Bowel Function in Spinal Cord Injury - This study is currently recruiting patients (Current: 23 Nov 2006)
Study Evaluating Oral MOA-728 for the Treatment of Opioid-Induced Bowel Dysfunction (OIBD) in Subjects With Chronic Non-Malignant Pain - This study is currently recruiting patients (Current: 23 Nov 2006) - MOA-728
Predictors of Constipation in Healthy Children - This study is currently recruiting patients (Current: 23 Nov 2006)
Treatment of Functional Bowel Disorders - This study has been completed (Current: 23 Nov 2006) - Desipramine
An Evaluation of the Efficacy and Safety of Tegaserod 6 Mg Bid Given Orally to Chinese Patients With Chronic Constipation - This study has been completed (Current: 23 Nov 2006) - Tegaserod
Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation - This study is no longer recruiting patients (Current: 23 Nov 2006) - Lubiprostone
Study of Stapled Transanal Rectal Resection (STARR) Surgery in Refractory Constipation Associated With Obstructive Defecation Syndrome (ODS) - This study is currently recruiting patients (Current: 23 Nov 2006)
Evaluate the Safety and Efficacy of a 5-HT4 Agonist in Chronic Constipation - This study is currently recruiting patients (Current: 23 Nov 2006) - TD-5108
Effect of Chinese Herb on Chronic Constipation for Residents in Long-Term Care Units - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Chinese Herb: CCH1
Effect of Tegaserod on Orocecal Transit in Elderly Chronic Constipation Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Tegaserod
Efficacy, Safety and Tolerability of Tegaserod in Patients With Chronic Constipation - This study is currently recruiting patients (Current: 23 Nov 2006) - Tegaserod
Assessment of Efficacy and Safety of Tegaserod in Male Patients With Chronic Constipation. - This study has been completed (Current: 23 Nov 2006) - Tegaserod
PolyethyleneGlycol3350 Laxative Vs Placebo in Constipated Children - This study has been completed (Current: 23 Nov 2006) - polyethyleneglycol3350
Comparison of PolyethyleneGlycol and Placebo for Relief of Constipation From Constipating Medications - This study has been completed (Current: 23 Nov 2006) - polyethyleneglycol3350
Polyethyleneglycol3350 Vs Tegaserod in Treatment of Patients With Chronic Constipation - This study has been completed (Current: 23 Nov 2006) - polyethyleneglycol3350
Extended Use of Polyethyleneglycol3350 Laxative in Constipated Patients - This study has been completed (Current: 23 Nov 2006) - polyethyleneglycol3350
Integrating Family Medicine and Pharmacy to Advance Primary Care Therapeutics - This study is currently recruiting patients (Current: 23 Nov 2006) - optimizing therapeutic treatments
An Open Label Study of Chronic Polyethyleneglycol3350 Use in Constipated Patients - This study has been completed (Current: 23 Nov 2006) - polyethyleneglycol3350
Mechano-Physiological Approach to Anorectal Function - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
Study of Long-Term Use of Forlax in Elderly Patients With Chronic Constipation - This study has been completed (Current: 23 Nov 2006) - PEG 4000 (Forlax ®)
Use of Pyridostigmine for Constipation in Diabetics - This study is currently recruiting patients (Current: 23 Nov 2006) - Pyridostigmine
Study Evaluating the Safety of MOA-728 Administered Orally to Healthy Subjects - This study is currently recruiting patients (Current: 23 Nov 2006) - MOA-728
A Trial of Point of Care Information in Ambulatory Pediatrics - This study has been completed (Current: 23 Nov 2006)
A Safety Study to Help Treat Constipation - This study has been completed (Current: 23 Nov 2006) - Methylnaltrexone
Study of Methylnaltrexone (MNTX) for the Relief of Constipation - This study has been completed (Current: 23 Nov 2006) - Methylnaltrexone
To Determine the Effect of Forlax Treatment in Children With Chronic Constipation Who May Also Suffer From Soiling/ Faecal Incontinence. - This study is currently recruiting patients (Current: 23 Nov 2006) - PEG 4000 (Forlax®)
Prevention of Constipation - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
The Effects of Tegaserod Vs. Placebo on Whole Gut Transit Time in Patients With Chronic Constipation and Dyspepsia - This study was withdrawn prior to recruitment (Current: 23 Nov 2006) - Tegaserod and Placebo
Efficacy and Safety of Tegaserod in Opioid-Induced Constipation in Patients With Non-Cancer Pain - This study is currently recruiting patients (Current: 23 Nov 2006) - Tegaserod
Safety and Efficacy of Tegaserod in Opioid-Induced Constipation in Patients With Non-Cancer Pain. - This study is currently recruiting patients (Current: 23 Nov 2006) - Tegaserod
Naloxone in Treating Constipation in Patients Who Are Receiving Opioids for Chronic Pain - This study is no longer recruiting patients (Current: 23 Nov 2006) - naloxone
A Study to Evaluate the Safety, Tolerability and Pharmacodynamics of DDP733 for IBS-c - This study is currently recruiting patients (Current: 23 Nov 2006) - DDP733
Efficacy and Safety of Lubiprostone in Patients With Irritable Bowel Syndrome With Constipation - This study is no longer recruiting patients (Current: 23 Nov 2006) - Lubiprostone
The Effect of Tegaserod on Patterns of Flow in the Small Bowel of Patients With Irritable Bowel Syndrome (IBS) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Tegaserod
Safety and Efficacy Study in the Treatment of Intestinal Problems Associated With Autism - This study is no longer recruiting patients (Current: 23 Nov 2006) - Oralgam (human immunoglobulin)
Phase 2 Study of MD-1100 Acetate on Gastrointestinal Transit in Patients With C-IBS - This study is currently recruiting patients (Current: 23 Nov 2006) - MD-1100 Acetate
Study 767905/008 Extension Study: Alvimopan for the Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects - This study is currently recruiting patients (Current: 23 Nov 2006) - alvimopan
Effect of Lumbo-Sacral Magnetic Stimulation on Colonic Motility - This study is currently recruiting patients (Current: 23 Nov 2006)
A Six-Month Study to Compare Outcome Differences and Visceral Response ... Irritable Bowel Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
Investigation of the Safety and Efficacy of Renzapride in Constipation Predominant Irritable Bowel Syndrome (IBS) - This study is currently recruiting patients (Current: 23 Nov 2006) - Renzapride
Octreotide as Palliative Therapy for Cancer-Related Bowel Obstruction That Cannot Be Removed by Surgery - This study has been completed (Current: 23 Nov 2006) - octreotide
Endoscopic Placement of Metal Stents in Treating Patients With Cancer- Related Duodenal Obstruction - This study is no longer recruiting patients (Current: 23 Nov 2006) - bowel obstruction management
Endoscopic Placement of Metal Stent in Patients With Cancer-Related Bowel Obstruction - This study is no longer recruiting patients (Current: 23 Nov 2006) - bowel obstruction management

Drugs used in Clinical Trials for Constipation

The format for each of the following is:

The drug,
followed by the name of the trial,
followed by whether the trial is recruiting patients,
- The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
- Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Constipation: