Clinical Trials for Cornea disorders

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Cornea disorders is grouped into the following categories:-

• View by trial name
• View by drugs used in Cornea disorders clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Cornea disorders:

• Dynamic Light Scattering and Keratoscopy for Corneal Examination - This study has been completed (Current: 23 Nov 2006)
• Screening Aid to Identify Corneas That May Have Pathologies or Other Conditions - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Novel Diagnostics With Optical Coherence Tomography: Imaging the Anterior Eye - This study is currently recruiting patients (Current: 23 Nov 2006)
• Studies in Families With Corneal Dystrophy or Other Inherited Corneal Diseases - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cornea Donor Study (CDS) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study of Dehydrex in Patients With Corneal Erosion - This study is currently recruiting patients (Current: 23 Nov 2006) - Dehydrex
• Tissue Studies of Human Eye Diseases - This study is currently recruiting patients (Current: 23 Nov 2006)
• Evaluation and Treatment of Patients With Corneal and External Diseases - This study is currently recruiting patients (Current: 23 Nov 2006) - Standard of care treatment
• The Efficacy of Two Potential Diagnostic Assays for Herpes Simplex Keratitis (HSK) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Herpetic Eye Disease Study (HEDS) I - This study has been completed (Current: 23 Nov 2006) - Prednisolone Phosphate,Acyclovir
• Herpetic Eye Disease Study (HEDS) II - This study is no longer recruiting patients (Current: 23 Nov 2006) - Acyclovir
• The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Structure of the Herpes Simplex Virus Receptor - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Treatment of Dry Eye Syndrome With Cyclosporin A Eye Drops - This study has been completed (Current: 23 Nov 2006)
• Screening for NEI Clinical Studies - This study is currently recruiting patients (Current: 23 Nov 2006)
• Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization - This study is currently recruiting patients (Current: 23 Nov 2006) - Dihematoporphyrin derivative,prednisolone
• Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome - This study has been completed (Current: 23 Nov 2006) - Ophthalmic Emulsion
• Study of INS365 Ophthalmic Solution in a Controlled Adverse Environment in Patients With Dry Eye - This study has been completed (Current: 23 Nov 2006) - INS365 Ophthalmic Solution
• Safety and Efficacy of Pimecrolimus Ophthalmic Suspension in Patients With Moderate to Severe Keratoconjunctivitis Sicca - This study is no longer recruiting patients (Current: 23 Nov 2006) - Pimecrolimus
• The Application of Fibrin Glue in Ocular Surface Diseases - This study is currently recruiting patients (Current: 23 Nov 2006) - tissue fibrin glue application (Tisseel)
• The Pathogenesis of Superior Limbic Keratoconjunctivitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study of Rebamipide Eye Drops to Treat Dry Eye - This study is currently recruiting patients (Current: 23 Nov 2006) - Rebamipide
• Study of Rebamipide Eye Drops to Treat Dry Eye - This study is currently recruiting patients (Current: 23 Nov 2006) - Rebamipide
• Trachoma Elimination Follow-Up - This study is no longer recruiting patients (Current: 23 Nov 2006) - Mass treatment with oral azithromycin to an entire village
• Azithromycin in Control of Trachoma II - This study is no longer recruiting patients (Current: 23 Nov 2006) - Azithromycin
• Trachoma Amelioration in Northern Amhara (TANA) - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Mass treatment with oral azithromycin to an entire community
• Steroids for Corneal Ulcers Trial - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - antibiotic (Moxifloxacin 0.5%) + corticosteroid (Prednisolone Phosphate 1% and preservative) or antibiotic + placebo (0.9% NaCl solution with preservative)
• Transplantation of Tissue Cultured Human Amniotic Epithelial Cells Onto Damaged Ocular Surfaces - This study is currently recruiting patients (Current: 23 Nov 2006)
• Effects of Systane Versus Saline in Maintaining Tear Film Stability at Determined Time Points - This study is currently recruiting patients (Current: 23 Nov 2006) - Systane Ocular Drops (OTC),Placebo - Saline Drops
• A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Clinical Study of Keratoconus in Asian Patients and Assessment of Different Topographic Patterns of Keratoconus in Asian Patients - This study has been completed (Current: 23 Nov 2006)
• Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Intacs for Keratoconus - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study of Three Alternatives for Mass Treatment in Trachoma Villages of Tanzania - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Effect of Intensive Fly Control on Trachoma and Ocular Chlamydia Infection in Tanzania - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Impact of Water and Health Education Programs on Trachoma and Ocular C. Trachomatis in Niger - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Safety and Efficacy Study of CF101 to Treat Keratoconjunctivitis Sicca - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - CF101
• Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% Versus Oral Azithromycin in Treatment of Trachoma - This study has been completed (Current: 23 Nov 2006) - Azithromycin
• Management of Patients With Keratoconus With Intacs - This study has been terminated (Current: 23 Nov 2006)
• A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers - This study is no longer recruiting patients (Current: 23 Nov 2006) - Povidone-Iodine
• Digital Photography to Evaluate Dry Eye - This study is currently recruiting patients (Current: 23 Nov 2006)
• Evaluation and Treatment of Eye Complications of Vaccinia Vaccination - This study is currently recruiting patients (Current: 23 Nov 2006) - NP-016 Vaccine Immune Globulin (IV-VIG)
• Screening for Research Subjects With Anterior Segment Diseases - This study is currently recruiting patients (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Cornea disorders

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Cornea disorders:

• Acyclovir - Herpetic Eye Disease Study (HEDS) I - This study has been completed (Current: 23 Nov 2006)
• Acyclovir - Herpetic Eye Disease Study (HEDS) II - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Antibiotic (Moxifloxacin 0.5%) + Corticosteroid (Prednisolone Phosphate 1% And Preservative) Or Antibiotic + Placebo (0.9% Nacl Solution With Preservative) - Steroids for Corneal Ulcers Trial - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Azithromycin - Azithromycin in Control of Trachoma II - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Azithromycin - Efficacy and Safety of 2 Dosing Regimens of T1225 Eye Drops 1.5% Versus Oral Azithromycin in Treatment of Trachoma - This study has been completed (Current: 23 Nov 2006)
• CF101 - Safety and Efficacy Study of CF101 to Treat Keratoconjunctivitis Sicca - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Dehydrex - Study of Dehydrex in Patients With Corneal Erosion - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dihematoporphyrin derivative - Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization - This study is currently recruiting patients (Current: 23 Nov 2006)
• INS365 Ophthalmic Solution - Study of INS365 Ophthalmic Solution in a Controlled Adverse Environment in Patients With Dry Eye - This study has been completed (Current: 23 Nov 2006)
• Mass treatment with oral azithromycin to an entire community - Trachoma Amelioration in Northern Amhara (TANA) - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Mass treatment with oral azithromycin to an entire village - Trachoma Elimination Follow-Up - This study is no longer recruiting patients (Current: 23 Nov 2006)
• NP-016 Vaccine Immune Globulin (IV-VIG) - Evaluation and Treatment of Eye Complications of Vaccinia Vaccination - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ophthalmic Emulsion - Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome - This study has been completed (Current: 23 Nov 2006)
• Pimecrolimus - Safety and Efficacy of Pimecrolimus Ophthalmic Suspension in Patients With Moderate to Severe Keratoconjunctivitis Sicca - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Placebo - Saline Drops - Effects of Systane Versus Saline in Maintaining Tear Film Stability at Determined Time Points - This study is currently recruiting patients (Current: 23 Nov 2006)
• Povidone-Iodine - A Clinical Trial of Povidone-Iodine for the Treatment of Bacterial Corneal Ulcers - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Prednisolone Phosphate - Herpetic Eye Disease Study (HEDS) I - This study has been completed (Current: 23 Nov 2006)
• Prednisolone - Randomized Study of Photodynamic Therapy Using Dihematoporphyrin in Patients With Corneal Neovascularization - This study is currently recruiting patients (Current: 23 Nov 2006)
• Rebamipide - Study of Rebamipide Eye Drops to Treat Dry Eye - This study is currently recruiting patients (Current: 23 Nov 2006)
• Rebamipide - Study of Rebamipide Eye Drops to Treat Dry Eye - This study is currently recruiting patients (Current: 23 Nov 2006)
• Standard of care treatment - Evaluation and Treatment of Patients With Corneal and External Diseases - This study is currently recruiting patients (Current: 23 Nov 2006)
• Systane Ocular Drops (OTC) - Effects of Systane Versus Saline in Maintaining Tear Film Stability at Determined Time Points - This study is currently recruiting patients (Current: 23 Nov 2006)
• Tissue Fibrin Glue Application (Tisseel) - The Application of Fibrin Glue in Ocular Surface Diseases - This study is currently recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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