Creutzfeldt-Jakob Disease is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Creutzfeldt-Jakob Disease, or a subtype of Creutzfeldt-Jakob Disease, affects less than 200,000 people in the US population.
Ophanet, who are a consortium of European partners, currently defines a condition rare when if affects 1 person per 2,000. They list Creutzfeldt-Jakob Disease as a "rare disease". More information about Creutzfeldt-Jakob Disease is available from Orphanet
1-per-million ... see also overview of Creutzfeldt-Jakob Disease.
approx 1 in 1,000,000 or 0.00% or 271 people in USA [Source statistic for calcuation: "1-per-million" -- see also general information about data sources]
271 per year, 22 per month, 5 per week, 0 per day, 0 per hour, 0 per minute, 0 per second. [Source statistic for calculation: "1-per-million" -- see also general information about data sources]
It affects about one person in every one million people per year worldwide; in the United States there are about 200 cases per year. (Source: excerpt from Creutzfeldt-Jakob Disease Fact Sheet: NINDS) ... On the basis of mortality surveillance from 1979 to 1994, the annual incidence of CJD remained stable at approximately 1 case per million persons in the United States. (Source: excerpt from Facts About Creutzfeldt-Jakob Disease: CDC-OC) ... The usual type of CJD occurs worldwide and strikes about one in a million people per year. (Source: excerpt from Update Follow-Up Study of NHPP Growth Hormone Recipients: NIDDK)
CJD occurs worldwide at a rate of about 1 case per million population per year. (Source: excerpt from Facts About Creutzfeldt-Jakob Disease: CDC-OC)
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The causative organism is difficult to identify because no foreign ribonucleic acid or deoxyribonucleic acid has been linked to the disease. CJD is believed to be caused by a specific protein called a prion, which lacks nucleic acids, resists proteolytic digestion, and spontaneously aggregates in the brain. Most cases are sporadic; 5% to 15% are familial, with an autosomal dominant pattern of inheritance. Although CJD isn’t transmitted by normal casual contact, human-to-human transmission can occur as a result of certain medical procedures, such as corneal and cadaveric dura mater grafts. Isolated cases are attributed to treatment during childhood with human growth hormone and to improperly decontaminated neurosurgical instruments and brain electrodes.
CJD generally affects adults ages 40 to 65 and occurs in more than 50 countries. Males and females are affected equally. In people younger than age 30, incidence is 5 in 1,000,000,000; in all other age groups, incidence is 1 in 1,000,000.
Source: Professional Guide to Diseases (Eighth Edition), 2005
The term 'prevalence' of Creutzfeldt-Jakob Disease usually refers to the estimated population of people who are managing Creutzfeldt-Jakob Disease at any given time. The term 'incidence' of Creutzfeldt-Jakob Disease refers to the annual diagnosis rate, or the number of new cases of Creutzfeldt-Jakob Disease diagnosed each year. Hence, these two statistics types can differ: a short-lived disease like flu can have high annual incidence but low prevalence, but a life-long disease like diabetes has a low annual incidence but high prevalence. For more information see about prevalence and incidence statistics.
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