Inheritance and Genetics of Crohn's disease

Crohn's disease Genetics: Book Excerpts

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Crohn's disease: Genetics Information

Genetics of Crohn's disease: About 20% of cases of Crohn's disease appear to run in families. It is a "complex trait," which means that several genes at different locations in the genome may contribute to the disease. A susceptibility locus for the disease was recently mapped to chromosome 16. Candidate genes found in this region include several involved in the inflamatory response, including: CD19, involved in B-lymphocyte function; sialophorin, involved in leukocyte adhesion; the CD11 integrin cluster, involved in microbacterial cell adhesion; and the interleukin-4 receptor, which is interesting, as IL-4-mediated functions are altered in IBDs. (Source: Genes and Disease by the National Center for Biotechnology)

About inheritance and genetics:

Inheritance of Crohn's disease refers to whether the condition is inherited from your parents or "runs" in families. The level of inheritance of a condition depends on how important genetics are to the disease. Strongly genetic diseases are usually inherited, partially genetic diseases are sometimes inherited, and non-genetic diseases are not inherited. For general information, see Introduction to Genetics.

 » Next page: Treatments for Crohn's disease

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