Hypercortisolism
Hypercortisolism: Excerpt from A Pocket Manual of Differential Diagnosis
Acute or chronic physical illness
Alcoholism
Depression
Elevated levels of cortisol-binding globulin
Congenital
Estrogens
Pregnancy
Pulsatile cortisol secretion (normal)
Cushing's syndrome
ACTH-dependent Cushing's syndrome
Pituitary tumor secreting ACTH
Ectopic
Intrasellar
Ectopic ACTH production
Appendicular carcinoma
Carcinoids
Bronchial carcinoid
Carcinoids of the gut
Oncocytic carcinoid of the kidney
Ovarian carcinoid
Pancreatic carcinoid
Thymic carcinoid
Colonic carcinoma
Cystadenoma of the pancreas
Epithelial carcinoma of the thymus
Esophageal carcinoma
Gastric carcinoma
Ileal carcinoma
Medullary carcinoma of the thyroid
Melanoma
Oat cell carcinoma of the lung
Ovarian tumors
Pancreatic islet cell carcinoma
Paraganglioma
Pheochromocytoma
Prostatic carcinoma
Squamous cell carcinomas
Cervix
Larynx
Lung
Ectopic corticotropin-releasing hormone–secreting tumor
Bronchial carcinoid
Gangliocytoma
Medullary carcinoma of the thyroid
Oat cell carcinoma of the lung
Prostatic carcinoma
Pheochromocytoma
ACTH-independent Cushing's syndrome
Factitious (surreptitious ingestion of glucocorticoids)
Iatrogenic (glucocorticoid therapy)
Primary adrenal tumor
Adenoma
Carcinoma
Adrenal hyperplasias causing Cushing's syndrome
Bilateral macronodular hyperplasia
ACTH-dependent
ACTH-independent
Bilateral micronodular dysplasia
With atrophy of intervening non-nodular cortex
Primary pigmented nodular adrenal disease
(autosomal dominant)
Sporadic
With hyperplasia of intervening non-nodular cortex
Gastrointestinal peptide-dependent adrenocortical hyperplasia
Nodular adrenal hyperplasia secondary to abnormal production of 21-deoxycortisol
Nodular adrenal hyperplasia secondary to abnormal expression of beta adrenergic receptors on adrenocortical cells
References
1. Schteingart GE: Cushing Syndrome, pp. 667–669. See Bibliography, 2.
2. Orth DN, Kovacs WJ: The Adrenal Cortex, pp. 569–595. See Bibliography, 3.
3. Kannan CR: The Adrenal Cortex, pp. 138–140. See Bibliography, 7.
Book Source Details
- Book Title: A Pocket Manual of Differential Diagnosis
- Author(s): Stephen N. Adler, Dianne B. Gasbarra
- Year of Publication: 1999
- Copyright Details: A Pocket Manual of Differential Diagnosis, Copyright © 1999 Lippincott Williams & Wilkins.
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Copyright notice for book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.
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