Prevalence and Incidence of Cushing's syndrome

Prevalance of Cushing's syndrome:

2-5 per million (NIDCD); 10 per million; 10-15 per million

Prevalance Rate:

approx 1 in 500,000 or 0.00% or 543 people in USA [about data]

Cushing's syndrome:

Cushing's syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Cushing's syndrome, or a subtype of Cushing's syndrome, affects less than 200,000 people in the US population.

Ophanet, who are a consortium of European partners, currently defines a condition rare when if affects 1 person per 2,000. They list Cushing's syndrome as a "rare disease". More information about Cushing's syndrome is available from Orphanet

Incidence (annual) of Cushing's syndrome:

estimated 10 to 15 per million people develop Cushing’s syndrome each year in the US (NIDDK, NIH, 2002)

Incidence Rate:

approx 1 in 100,000 or 0.00% or 2,720 people in USA [about data]

Incidence extrapolations for USA for Cushing's syndrome:

2,720 per year, 226 per month, 52 per week, 7 per day, 0 per hour, 0 per minute, 0 per second.

Prevalance of Cushing's syndrome:

it is relatively rare and most commonly affects adults aged 20 to 50. An estimated 10 to 15 of every million people are affected each year. (Source: excerpt from Cushing's Syndrome: NIDDK)

Prevalence/Incidence of Cushing's syndrome: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review the full text of medical books online, free, without registration, for more information about the prevalence and/or incidence of Cushing's syndrome.

Cushing's syndrome: Causes and incidence
(Professional Guide to Diseases (Eighth Edition))

In approximately 70% of patients, Cushing’s syndrome results from excessive production of corticotropin and consequent hyperplasia of the adrenal cortex. Overproduction of corticotropin may stem from pituitary hypersecretion (Cushing’s disease), a corticotropin-producing tumor in another organ (particularly bronchogenic or pancreatic cancer), or excessive administration of exogenous glucocorticoids.

In the remaining 30% of patients, Cushing’s syndrome results from a cortisol-secreting adrenal tumor, which is usually benign. In infants, the usual cause of Cushing’s syndrome is adrenal carcinoma.

Cushing’s syndrome affects 13 of every 1 million people. It’s more common in females than in males and occurs primarily between ages between ages 25 and 40.

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About prevalence and incidence statistics:

The term 'prevalence' of Cushing's syndrome usually refers to the estimated population of people who are managing Cushing's syndrome at any given time. The term 'incidence' of Cushing's syndrome refers to the annual diagnosis rate, or the number of new cases of Cushing's syndrome diagnosed each year. Hence, these two statistics types can differ: a short-lived disease like flu can have high annual incidence but low prevalence, but a life-long disease like diabetes has a low annual incidence but high prevalence. For more information see about prevalence and incidence statistics.