Clinical Trials for Diabetic Retinopathy

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Diabetic Retinopathy is grouped into the following categories:-

• View by trial name
• View by drugs used in Diabetic Retinopathy clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Diabetic Retinopathy:

• Screening for Studies on Retinovascular Diseases - This study is currently recruiting patients (Current: 23 Nov 2006)
• Diabetic Retinopathy and Visual Function Study - This study has been completed (Current: 23 Nov 2006)
• Long Term Follow-Up of Diabetic Retinopathy - This study has been completed (Current: 23 Nov 2006)
• Long-Term Follow-Up of Patients Enrolled in the Early Treatment Diabetic Retinopathy Study (ETDRS) - This study has been completed (Current: 23 Nov 2006)
• Blood Factors and Diabetic Retinopathy - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Research Study in Patients With Persistent Macular Edema - This study is no longer recruiting patients (Current: 23 Nov 2006) - DEX PS DDS®
• Study to Evaluate the Effectiveness of a Program Developed to Improve Eye Care for Veterans With Diabetes - This study has been completed (Current: 23 Nov 2006)
• Intravitreal Long Acting Gas in the Prevention of Early Postoperative Vitreous Hemorrhage in Diabetic Vitrectomy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Triamcinolone Acetonide Injections to Treat Diabetic Macular Edema - This study has been completed (Current: 23 Nov 2006) - Peribulbar Triamcinolone Acetonide
• Extension Study of the Long-Term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-Proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy - This study is no longer recruiting patients (Current: 23 Nov 2006) - Octreotide acetate in microspheres
• A Pilot Study for the Treatment of Iris Neovascularization With Macugen - This study is currently recruiting patients (Current: 23 Nov 2006) - Macugen injection intravitreally AND Panretinal Photocoagulation Laser
• Intravitreal Bevacizumab Vs Photocoagulation for Proliferative Diabetic Retinopathy - This study is currently recruiting patients (Current: 23 Nov 2006) - intravitreal injection of bevacizumab
• Metabolic Mapping to Measure Retinal Metabolism - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efficacy Study of Lucentis in the Treatment of Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006) - Ranibizumab (Lucentis)
• Octreotide Acetate in Microspheres in Patients With Diabetic Retinopathy - This study has been completed (Current: 23 Nov 2006) - Octreotide Acetate in Microspheres
• Octreotide Acetate in Microspheres in Patients With Diabetic Retinopathy - This study is no longer recruiting patients (Current: 23 Nov 2006) - Octreotide Acetate in Microspheres
• Extension Study of Long-Term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-Proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy - This study is no longer recruiting patients (Current: 23 Nov 2006) - Octreotide acetate in microspheres
• Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR) - This study is currently recruiting patients (Current: 23 Nov 2006) - bevacizumab
• Novel Diagnostics With Optical Coherence Tomography: Retinal Imaging - This study is currently recruiting patients (Current: 23 Nov 2006)
• Study to Assess the Efficacy and Safety of Monthly Octreotide Intramuscular Injections in Patients With Proliferative Diabetic Retinopathy After Lasercoagulation This Study is Not Being Conducted in the United States. - This study is no longer recruiting patients (Current: 23 Nov 2006) - Octreotide, 30 mg i.m. LAR formulation
• Diabetic Retinopathy Vitrectomy Study (DRVS) - This study has been completed (Current: 23 Nov 2006)
• Early Treatment Diabetic Retinopathy Study (ETDRS) - This study has been completed (Current: 23 Nov 2006) - Aspirin
• Krypton-Argon Regression of Neovascularization Study (KARNS) - This study has been completed (Current: 23 Nov 2006)
• Sorbinil Retinopathy Trial (SRT) - This study has been completed (Current: 23 Nov 2006) - Sorbinil
• Diabetic Retinopathy Study (DRS) - This study has been completed (Current: 23 Nov 2006)
• Multi-Ethnic Study of Atherosclerosis (MESA) - Ancillary Eye Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pilot Study of Laser Photocoagulation Therapy for Diabetic Macular Edema - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Reduction in the Occurrence of Center-Threatening Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006) - Ruboxistaurin,placebo
• Intravitreal v. Sub-Tenon Injections of Triamcinolone Acetonide for Macular Edema in Retinal Disorders - This study is currently recruiting patients (Current: 23 Nov 2006) - Triamcinolone Acetonide
• Treatment of Diabetic Macular Edema: Triamcinolone Injections Vs. Laser Photocoagulation - This study is currently recruiting patients (Current: 23 Nov 2006) - Triamcinolone Acetonide
• Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment - This study is currently recruiting patients (Current: 23 Nov 2006) - Vitrase (ovine hyaluronidase) 93 USP units
• Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage - This study has been completed (Current: 23 Nov 2006) - Vitrase (ovine hyaluronidase)
• Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage - This study has been completed (Current: 23 Nov 2006) - Vitrase (ovine hyaluronidase)
• Treatment of Diabetic Retinopathy With Open-Label Anecortave Acetate Sterile Suspension (15 Mg) - This study is currently recruiting patients (Current: 23 Nov 2006) - Anecortave Acetate Sterile Suspension (15mg)
• PST/Laser v. Laser Alone for CSME - This study is currently recruiting patients (Current: 23 Nov 2006) - triamcinolone acetonide
• Treatment for Completers of the Study B7A-MC-MBCM - This study is currently recruiting patients (Current: 23 Nov 2006) - ruboxistaurin
• A Phase 2 Evaluation of Anti-VEGF Therapy for Diabetic Macular Edema: Bevacizumab (Avastin) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Tracking Optical Coherence Tomography - This study is currently recruiting patients (Current: 23 Nov 2006)
• Green Laser Photocoagulation Study in Proliferative Diabetic Retinopathy - This study has been completed (Current: 23 Nov 2006)
• Safety and Tolerability of MS-R001 in Patients With Diabetic Macular Edema Secondary to Diabetic Retinopathy - This study is currently recruiting patients (Current: 23 Nov 2006) - MS-R001 (rapamycin)
• Treatment of Rubeosis Iridis With Open-Label Anecortave Acetate Sterile Suspension ( 15 Mg.). - This study is no longer recruiting patients (Current: 23 Nov 2006) - anecortave acetate
• Pegaptanib Sodium Compared to Sham Injection in Patients With DME Involving the Center of the Macula - This study has been completed (Current: 23 Nov 2006) - pegaptanib sodium (Macugen)
• A Pilot Study of Laser Photocoagulation for Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Effect of Ruboxistaurin on Clinically Significant Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006) - ruboxistaurin,placebo
• A Multicentre Randomised Clinical Trial of Laser Treatment Plus Intravitreal Triamcinolone for Diabetic Macular Oedema - This study is currently recruiting patients (Current: 23 Nov 2006) - Triamcinolone acetate
• Open Label Extension of a Clinical Trial of Intravitreal Triamcinolone for Diabetic Macular Oedema-TDMX Study - This study is no longer recruiting patients (Current: 23 Nov 2006) - Triamcinolone acetate
• Pegaptanib Sodium (Macugen) Compared to Sham Injection in Patients With Diabetic Macular Edema (DME) Involving the Center of the Macula - This study is currently recruiting patients (Current: 23 Nov 2006) - pegaptanib sodium (Macugen)
• Intravitreal Triamcinolone for Clinically Significant Diabetic Macular Oedema That Persists After Laser Treatment (TDMO) - This study has been completed (Current: 23 Nov 2006) - Triamcinolone acetate
• A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006) - dexamethasone
• A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006) - dexamethasone
• Triamcinolone Vs. Laser for Diabetic Macular Edema - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Triamcinolone acetonide
• Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006) - Cand5
• A Study of the Safety and Efficacy of SK-0503 for Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006) - dexamethasone
• Phase 1 Study of VEGF Trap in Patients With Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006) - VEGF Trap
• Quantification of Rising the Osmotic Pressure in Diabetic Intraretinal Fluid Accumulation (Diabetic Macular Oedema) - This study is no longer recruiting patients (Current: 23 Nov 2006) - Glycerol
• Fluocinolone Acetonide Implant Compared to Sham Injection in Patients With Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006) - fluocinolone acetonide
• Intravitreal Triamcinolone Acetonide Versus Laser for Diabetic Macular Edema - This study is no longer recruiting patients (Current: 23 Nov 2006) - Intravitreal Triamcinolone Acetonide
• A Pilot Study of Peribulbar Triamcinolone Acetonide for Diabetic Macular Edema - This study is no longer recruiting patients (Current: 23 Nov 2006) - triamcinolone acetonide injection
• A Randomized, Placebo-Controlled Clinical Trial of Intravitreal Triamcinolone for Refractory Diabetic Macular Edema - This study has been completed (Current: 23 Nov 2006) - Triamcinolone acetonide
• Bevacizumab Versus Combined Bevacizumab and Triamcinolone for Refractory Diabetic Macular Edema; a Randomized Clinical Trial - This study is no longer recruiting patients (Current: 23 Nov 2006) - Triamcinolone,Bevacizumab
• Effect of Intravitreal Bevacizumab on Clinically Significant Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006) - bevacizumab, triamcinolone acetonide
• Sequentially Combined Vitrectomy, IVTA and Macular Focal Laser Photocoagulation for Diabetic Macular Edema - This study has been completed (Current: 23 Nov 2006) - intravitreal triamcinolone acetonide
• Evaluation and Treatment of Patients With Retinal Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Standard of care treatment
• Laser and Medical Treatment of Diabetic Macular Edema - This study has been completed (Current: 23 Nov 2006) - Vitamin E
• A Multicenter Study to Evaluate Retisert in the Treatment of Patients With Diabetic Macular Edema - This study is no longer recruiting patients (Current: 23 Nov 2006) - Retisert Implant
• Eye Injections of Triamcinolone Acetonide for Retinal Blood Vessel Disorders - This study is no longer recruiting patients (Current: 23 Nov 2006) - Triamcinolone Acetonide (TAC-PF)
• Comparison of Insulin Glargine and NPH Human Insulin in Progression of Diabetic Retinopathy in Type 2 Diabetic Patients - This study is no longer recruiting patients (Current: 23 Nov 2006) - Insulin glargine
• Safety Study in Retinal Transplantation for Retinitis Pigmentosa. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Safety Study in Retinal Transplantation for Dry Age Related Macular Degeneration. - This study is currently recruiting patients (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Diabetic Retinopathy

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Diabetic Retinopathy:

• Anecortave Acetate Sterile Suspension (15mg) - Treatment of Diabetic Retinopathy With Open-Label Anecortave Acetate Sterile Suspension (15 Mg) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Anecortave Acetate - Treatment of Rubeosis Iridis With Open-Label Anecortave Acetate Sterile Suspension ( 15 Mg.). - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Aspirin - Early Treatment Diabetic Retinopathy Study (ETDRS) - This study has been completed (Current: 23 Nov 2006)
• Bevacizumab, Triamcinolone Acetonide - Effect of Intravitreal Bevacizumab on Clinically Significant Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bevacizumab - Bevacizumab Versus Combined Bevacizumab and Triamcinolone for Refractory Diabetic Macular Edema; a Randomized Clinical Trial - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Bevacizumab - Intravitreal Bevacizumab for Management of Active Progressive Proliferative Diabetic Retinopathy (PDR) - This study is currently recruiting patients (Current: 23 Nov 2006)
• Cand5 - Safety and Efficacy Study of Small Interfering RNA Molecule (Cand5) to Treat Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• DEX PS DDS® - Research Study in Patients With Persistent Macular Edema - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Dexamethasone - A Study of the Safety and Efficacy of SK-0503 for Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dexamethasone - A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dexamethasone - A Study of the Safety and Efficacy of a New Treatment for Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Fluocinolone Acetonide - Fluocinolone Acetonide Implant Compared to Sham Injection in Patients With Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Glycerol - Quantification of Rising the Osmotic Pressure in Diabetic Intraretinal Fluid Accumulation (Diabetic Macular Oedema) - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Insulin glargine - Comparison of Insulin Glargine and NPH Human Insulin in Progression of Diabetic Retinopathy in Type 2 Diabetic Patients - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Intravitreal Injection Of Bevacizumab - Intravitreal Bevacizumab Vs Photocoagulation for Proliferative Diabetic Retinopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Intravitreal Triamcinolone Acetonide - Intravitreal Triamcinolone Acetonide Versus Laser for Diabetic Macular Edema - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Intravitreal Triamcinolone Acetonide - Sequentially Combined Vitrectomy, IVTA and Macular Focal Laser Photocoagulation for Diabetic Macular Edema - This study has been completed (Current: 23 Nov 2006)
• MS-R001 (rapamycin) - Safety and Tolerability of MS-R001 in Patients With Diabetic Macular Edema Secondary to Diabetic Retinopathy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Macugen injection intravitreally AND Panretinal Photocoagulation Laser - A Pilot Study for the Treatment of Iris Neovascularization With Macugen - This study is currently recruiting patients (Current: 23 Nov 2006)
• Octreotide Acetate in Microspheres - Octreotide Acetate in Microspheres in Patients With Diabetic Retinopathy - This study has been completed (Current: 23 Nov 2006)
• Octreotide Acetate in Microspheres - Octreotide Acetate in Microspheres in Patients With Diabetic Retinopathy - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Octreotide acetate in microspheres - Extension Study of Long-Term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-Proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Octreotide acetate in microspheres - Extension Study of the Long-Term Safety and Tolerability of Octreotide Acetate in Patients With Moderately Severe or Severe Non-Proliferative Diabetic Retinopathy or Low Risk Proliferative Diabetic Retinopathy - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Octreotide, 30 mg i.m. LAR formulation - Study to Assess the Efficacy and Safety of Monthly Octreotide Intramuscular Injections in Patients With Proliferative Diabetic Retinopathy After Lasercoagulation This Study is Not Being Conducted in the United States. - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Pegaptanib Sodium (Macugen) - Pegaptanib Sodium (Macugen) Compared to Sham Injection in Patients With Diabetic Macular Edema (DME) Involving the Center of the Macula - This study is currently recruiting patients (Current: 23 Nov 2006)
• Pegaptanib Sodium (Macugen) - Pegaptanib Sodium Compared to Sham Injection in Patients With DME Involving the Center of the Macula - This study has been completed (Current: 23 Nov 2006)
• Peribulbar Triamcinolone Acetonide - Triamcinolone Acetonide Injections to Treat Diabetic Macular Edema - This study has been completed (Current: 23 Nov 2006)
• Placebo - Effect of Ruboxistaurin on Clinically Significant Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Placebo - Reduction in the Occurrence of Center-Threatening Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ranibizumab (Lucentis) - Efficacy Study of Lucentis in the Treatment of Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Retisert Implant - A Multicenter Study to Evaluate Retisert in the Treatment of Patients With Diabetic Macular Edema - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Ruboxistaurin - Effect of Ruboxistaurin on Clinically Significant Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ruboxistaurin - Reduction in the Occurrence of Center-Threatening Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ruboxistaurin - Treatment for Completers of the Study B7A-MC-MBCM - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sorbinil - Sorbinil Retinopathy Trial (SRT) - This study has been completed (Current: 23 Nov 2006)
• Standard of care treatment - Evaluation and Treatment of Patients With Retinal Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Triamcinolone Acetonide (TAC-PF) - Eye Injections of Triamcinolone Acetonide for Retinal Blood Vessel Disorders - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Triamcinolone Acetonide Injection - A Pilot Study of Peribulbar Triamcinolone Acetonide for Diabetic Macular Edema - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Triamcinolone Acetonide - Intravitreal v. Sub-Tenon Injections of Triamcinolone Acetonide for Macular Edema in Retinal Disorders - This study is currently recruiting patients (Current: 23 Nov 2006)
• Triamcinolone Acetonide - PST/Laser v. Laser Alone for CSME - This study is currently recruiting patients (Current: 23 Nov 2006)
• Triamcinolone Acetonide - Treatment of Diabetic Macular Edema: Triamcinolone Injections Vs. Laser Photocoagulation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Triamcinolone acetate - A Multicentre Randomised Clinical Trial of Laser Treatment Plus Intravitreal Triamcinolone for Diabetic Macular Oedema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Triamcinolone acetate - Intravitreal Triamcinolone for Clinically Significant Diabetic Macular Oedema That Persists After Laser Treatment (TDMO) - This study has been completed (Current: 23 Nov 2006)
• Triamcinolone acetate - Open Label Extension of a Clinical Trial of Intravitreal Triamcinolone for Diabetic Macular Oedema-TDMX Study - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Triamcinolone acetonide - A Randomized, Placebo-Controlled Clinical Trial of Intravitreal Triamcinolone for Refractory Diabetic Macular Edema - This study has been completed (Current: 23 Nov 2006)
• Triamcinolone acetonide - Triamcinolone Vs. Laser for Diabetic Macular Edema - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Triamcinolone - Bevacizumab Versus Combined Bevacizumab and Triamcinolone for Refractory Diabetic Macular Edema; a Randomized Clinical Trial - This study is no longer recruiting patients (Current: 23 Nov 2006)
• VEGF Trap - Phase 1 Study of VEGF Trap in Patients With Diabetic Macular Edema - This study is currently recruiting patients (Current: 23 Nov 2006)
• Vitamin E - Laser and Medical Treatment of Diabetic Macular Edema - This study has been completed (Current: 23 Nov 2006)
• Vitrase (ovine hyaluronidase) 93 USP units - Assessment of Intravitreous Injections of Vitrase for Inducing Posterior Vitreous Detachment - This study is currently recruiting patients (Current: 23 Nov 2006)
• Vitrase (ovine hyaluronidase) - Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage - This study has been completed (Current: 23 Nov 2006)
• Vitrase (ovine hyaluronidase) - Safety and Efficacy Study of Vitrase for Clearance of Severe Vitreous Hemorrhage - This study has been completed (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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