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Blood transfusion reaction:
Signs and symptoms
(Professional Guide to Diseases (Eighth Edition))
Immediate effects of a hemolytic transfusion reaction develop within a few minutes or hours after the start of the transfusion and may include chills, fever, urticaria, tachycardia, dyspnea, nausea, vomiting, tightness in the chest, chest and back pain, hypotension, bronchospasm, angioedema, and signs and symptoms of anaphylaxis, shock, pulmonary edema, heart failure, and renal failure. In a surgical patient under anesthesia, these symptoms are masked, but blood oozes from mucous membranes or the incision site.
Delayed hemolytic reactions can occur up to several weeks after a transfusion, causing fever, an unexpected fall in serum hemoglobin (Hb) level, and jaundice.
Allergic reactions are typically afebrile and characterized by urticaria and angioedema, possibly progressing to cough, respiratory distress, nausea, vomiting, diarrhea, abdominal cramps, vascular instability, shock, and coma.
The hallmark of febrile nonhemolytic reactions is mild to severe fever that may begin at the start of transfusion or within 2 hours after its completion.
Bacterial contamination produces a high fever, nausea, vomiting, diarrhea, abdominal cramps and, possibly, shock. Symptoms of viral contamination may not appear for several weeks after transfusion.
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Source: Professional Guide to Diseases (Eighth Edition), 2005
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