Prevalence and Incidence of Down Syndrome
Ophanet, who are a consortium of European partners,
currently defines a condition rare when if affects 1 person per 2,000.
They list Down Syndrome as a "rare disease".
More information about Down Syndrome is available from Orphanet
Down Syndrome Prevalence: Book Excerpts
Incidence (annual) of Down Syndrome:
1-in-800 overall births ... see also overview of Down Syndrome.
Incidence Rate:
approx 1 in 800 or 0.12% or 340,000 people in USA [Source statistic for calcuation: "1-in-800 overall births" -- see also general information about data sources]
Incidence extrapolations for USA for Down Syndrome:
340,000 per year,
28,333 per month,
6,538 per week,
931 per day,
38 per hour,
0 per minute,
0 per second.
[Source statistic for calculation: "1-in-800 overall births" -- see also general information about data sources]
Incidence statistics for Down Syndrome:
The following statistics relate to the incidence of Down Syndrome:
- Incidence risk of Down syndrome increases with mother's age
- Less than 1-in-1,000 risk of Down syndrome for women under 30
- About 1-in-25 risk of Down syndrome for a 45-year-old mother
- 40 infants were born alive with Down Syndrome in the UK 2002 (University of Ulster, 2003)
- 4 fetal deaths or still births occurred due to Down Syndrome in the UK 2002 (University of Ulster, 2003)
- 26 cases of induced abortions occurred following prenatal diagnosis of Down Syndrome in the UK 2002 (University of Ulster, 2003)
- Down Syndrome occurred in 23.81 per 10,000 births in the UK 2002 (University of Ulster, 2003)
- more statistics...»
More Statistics about Down Syndrome:
Hospitalization statistics
Survival rate statistics
All statistics for Down Syndrome
Prevalence/Incidence of Down Syndrome: Online Medical Books
16 MEDICAL BOOKS ONLINE!
Review excerpts from medical books online, free, without registration,
for more information about the prevalence and/or incidence of Down Syndrome.
Trisomy 13 syndrome:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
Approximately 75% of all cases of trisomy 13 syndrome are caused by chromosomal nondisjunction. About 20% are due to chromosomal translocation involving a rearrangement of chromosomes 13 and 14. About 5% are estimated to be mosaics; the clinical effects in these cases may be less severe.
Incidence is estimated to be 1 in every 5,000 neonates. The risk of chromosomal abnormalities typically increases with advanced maternal age; however, the mean maternal age for this abnormality is about 31 years.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Down syndrome:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
Down syndrome usually results from trisomy 21, a spontaneous chromosomal abnormality in which chromosome 21 has three copies instead of the normal two because of faulty meiosis (nondisjunction) of the ovum or, sometimes, the sperm. This results in a karyotype of 47 chromosomes instead of the normal 46. In about 4% of patients, Down syndrome results from an unbalanced translocation in which the long arm of chromosome 21 breaks and attaches to another chromosome. Most commonly, this is a robertsonian translocation and results in an increased risk of having multiple children with Down syndrome. The disorder may also be due to chromosomal mosaicism with two cell lines — one with a normal number of chromosomes (46) and one with 47 (an extra chromosome 21).
Down syndrome occurs in 1 in 660 live births, but the incidence increases with advanced parental age, especially when the mother is age 34 or older at delivery or the father is older than age 42. At age 20, a woman has about one chance in 2,000 of having a child with Down syndrome; by age 49, she has one chance in 12. However, if a woman has had one child with Down syndrome, the risk of recurrence is 1% to 2% unless the trisomy results from translocation.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Trisomy 18 syndrome:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
Most cases of trisomy 18 syndrome are caused by spontaneous meiotic nondisjunction. The risk of chromosomal abnormalities typically increases with maternal age; however, the mean maternal age for this disorder is 32½. Incidence is 1 in 3,000 neonates, with females three times more likely to be affected than males.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Down (Trisomy 21) Syndrome:
Down Syndrome - epidemiology
(The 5-Minute Pediatric Consult)
- Male > Female (1.3:1)
- Best recognized and most frequent chromosomal syndrome of humans
- 1 of the 3 most common autosomal trisomies in humans (others are trisomy 18 and 13)
- Most common autosomal chromosomal abnormality causing mental retardation
- >50% of trisomy 21 fetuses are spontaneously aborted in early pregnancy.
Down Syndrome - incidence
1/600–1/800 live births, although incidence varies with maternal age:
- 1/1,500 for maternal ages 15–29 years
- 1/800 for maternal ages 30–34 years
- 1/270 for maternal ages 35–39 years
- 1/100 for maternal ages 40–49 years
» READ BOOK EXCERPT ONLINE »
Source: The 5-Minute Pediatric Consult, 2008
About prevalence and incidence statistics:
The term 'prevalence' of Down Syndrome usually refers to the estimated population
of people who are managing Down Syndrome at any given time.
The term 'incidence' of Down Syndrome refers to the annual diagnosis rate,
or the number of new cases of Down Syndrome diagnosed each year.
Hence, these two statistics types can differ:
a short-lived disease like flu can have high annual incidence but low prevalence,
but a life-long disease like diabetes has a low annual incidence but high prevalence.
For more information see about prevalence and incidence statistics.
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