Clinical Trials for Ear conditions

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Ear conditions is grouped into the following categories:-

• View by trial name
• View by drugs used in Ear conditions clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Ear conditions:

• Treatments for Postural Vertigo - This study is currently recruiting patients (Current: 23 Nov 2006)
• Autoimmunity in Inner Ear Disease - This study has been terminated (Current: 23 Nov 2006) - Corticosteroids,Methotrexate
• Acute Otitis Media: Adjuvant Therapy to Improve Outcome - This study has been completed (Current: 23 Nov 2006) - Antihistamine,Corticosteroid
• Vaccination for Middle Ear Infection - This study has been completed (Current: 23 Nov 2006)
• Genetic Analysis of Human Hereditary Hearing Impairment - This study is currently recruiting patients (Current: 23 Nov 2006)
• Endolymphatic Sac Tumors in a Population of Patients With Von Hippel-Lindau Disease:The Natural History and Pathobiology, and a Prospective Non-Randomized Clinical Trial of Hearing Preservation Surgery in Patients With Early Stage Endolymphatic Sac Tumors - This study has been completed (Current: 23 Nov 2006)
• Areas of Brain Responsible for Understanding American Sign Language - This study has been completed (Current: 23 Nov 2006)
• Testing a Possible Cause of Reduced Ability of Children to Process Speech in Noise - This study has been completed (Current: 23 Nov 2006)
• Pilot Study of Familial Nonsyndromal Mondini Dysplasia - This study has been completed (Current: 23 Nov 2006)
• Study of Dietary N-3 Fatty Acids in Patients With Retinitis Pigmentosa and Usher Syndrome - This study has been terminated (Current: 23 Nov 2006)
• Pilot Study of Vestibular Rehabilitation Training for Panic Disorder With Vestibular Dysfunction - This study has been completed (Current: 23 Nov 2006)
• Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 - This study has been completed (Current: 23 Nov 2006)
• NF2 Natural History Consortium - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Hereditary Deficits in Auditory Processing Leading to Language Impairment - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nervous System Manipulation and Botanicals for the Treatment of Recurrent Ear Infections in Children - This study has been completed (Current: 23 Nov 2006) - Botanicals
• Effects of Stimulus Validity on Speech Recognition - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Evaluation of Treatment Methods for Clinically Significant Tinnitus - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Measurement and Prediction of Outcomes of Amplification - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Quantifying Auditory Perceptual Learning Following Hearing Aid Fitting - This study is currently recruiting patients (Current: 23 Nov 2006)
• Early Diagnosis of Steroid-Responsive & No-Responsive Hearing Loss - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Genetic Analysis of Usher Syndrome in Ashkenazi Jews - This study has been completed (Current: 23 Nov 2006)
• Adenoidectomy for Otitis Media in 2-3 Year Old Children - This study has been terminated (Current: 23 Nov 2006)
• Epidemiology of Hearing Loss in Diabetic and Non-Diabetic Veterans - This study has been completed (Current: 23 Nov 2006)
• Clinical and Genetic Analysis of Inner Ear Malformations - This study is currently recruiting patients (Current: 23 Nov 2006)
• Genetic Analysis of Hereditary Disorders of Hearing and Balance - This study is currently recruiting patients (Current: 23 Nov 2006)
• An Implant for Hearing Loss Due to Removal of Neurofibromatosis 2 Tumors - This study has been completed (Current: 23 Nov 2006)
• Complementary/Alternative Medicine for Abnormality in the Vestibular (Balance) System - This study has been completed (Current: 23 Nov 2006)
• Functioning, Disability, and Quality of Life in the Adult Hearing Impaired - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Study of the Effectiveness and Safety of Levofloxacin in Treating Children With a Rapid and Severe Onset of Infection and Inflammation of the Middle Ear That is Difficult to Treat - This study is no longer recruiting patients (Current: 23 Nov 2006) - levofloxacin
• Levofloxacin In The Treatment Of Children With Recurrent And/or Persistent Acute Otitis Media - This study is no longer recruiting patients (Current: 23 Nov 2006) - levofloxacin; amoxicillin/clavulanate
• Sudden Hearing Loss Multicenter Treatment Trial - This study is currently recruiting patients (Current: 23 Nov 2006) - oral prednisone,intratympanic methylprednisolone
• Audiology Visits After Screening for Hearing Loss: An RCT - This study is currently recruiting patients (Current: 23 Nov 2006)
• Natural History and Genetic Studies of Usher Syndrome - This study is currently recruiting patients (Current: 23 Nov 2006)
• The Effect of Folic Acid on Atherosclerosis, Cognitive Performance and Hearing - This study has been completed (Current: 23 Nov 2006)
• Efficacy Against Otitis Media in Children With 11 Valent Pneumococcal Vaccine - This study has been completed (Current: 23 Nov 2006)
• The Effect of Tinnitus Retraining Therapy on Subjective and Objective Measures of Chronic Tinnitus - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• The Performance-Perceptual Test as a Counseling Tool - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Sildenafil For Meniere's Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Sildenafil
• Use of a Vibrotactile Sensory Prosthesis in Patients With Postural Imbalance and Spatial Disorientation - This study is currently recruiting patients (Current: 23 Nov 2006)
• Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy - This study is currently recruiting patients (Current: 23 Nov 2006) - Betahistine 24 mg bid (Betaserc)
• Prevention Recurrent Otitis Media in the Young Children - This study is no longer recruiting patients (Current: 23 Nov 2006)
• The Phonak EduLink-System in Students With Specific Performance Deficits in Speech-in-Noise Intelligibility - This study is currently recruiting patients (Current: 23 Nov 2006)
• Comparative Study to Evaluate the Efficacy and Safety of Telithromycin Given Once Daily Versus Cefuroxime Axetil Given Twice Daily in Children With Middle Ear Infections - This study is currently recruiting patients (Current: 23 Nov 2006) - telithromycin
• Canalith Repositioning Procedure for BPPV in Primary Care - This study has been completed (Current: 23 Nov 2006)
• Effectiveness of Sulfamethoxazole-Trimethoprim in the Treatment of Chronic Otitis Media - This study is no longer recruiting patients (Current: 23 Nov 2006) - sulfamethoxazole-trimethoprim
• A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children - This study has been completed (Current: 23 Nov 2006) - Montelukast
• Study of Streptococcus Pneumoniae in Nose and Throats of Infants With Acute Otitis Media - This study is currently recruiting patients (Current: 23 Nov 2006) - Prevenar
• Efficacy of the Bone-Anchored Hearing Aid for Unilateral Deafness - This study is currently recruiting patients (Current: 23 Nov 2006)
• Bilateral Benefit in Adult Users of the HiRes 90K Bionic Ear System - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Long-Term Study of the Incidence of Musculoskeletal Disorders in Children Who Have Received Levofloxacin or a Standard Non-Fluoroquinone Therapy for Acute Bacterial Infection - This study is no longer recruiting patients (Current: 23 Nov 2006) - levofloxacin
• Neonatal Immunization With Pneumococcal Conjugate Vaccine in Papua New Guinea - This study is currently recruiting patients (Current: 23 Nov 2006)
• Audiometric Parameters in Conductive Hearing Loss and Middle Ear Disease - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Multi-Site Randomized Clinical Study of Tinnitus Treatment Methods - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Wait and See Antibiotic Prescription for Acute Otitis Media: A Randomized Controlled Trial - This study has been completed (Current: 23 Nov 2006)
• Safety and Efficacy of the BrainPort Balance Device to Improve Balance in Bilateral Vestibular Hypofunction - This study is currently recruiting patients (Current: 23 Nov 2006)
• The Effect of Gabapentin on the Sensation and Impact of Tinnitus - This study has been completed (Current: 23 Nov 2006) - gabapentin
• The Hearing Aid Effectiveness After Aural Rehabilitation (HEAR) Trial - This study is currently recruiting patients (Current: 23 Nov 2006)
• Efficacy of Digital Noise Reduction Strategies: A Hearing Aid Trial - This study is currently recruiting patients (Current: 23 Nov 2006)
• Neural Changes in the Aging Auditory System - This study has been completed (Current: 23 Nov 2006) - Hormone Replacement Therapy - HRT
• A Study of the Clinicopathologic Behaviour of the Different Types of Unsafe Chronic Otitis Media - This study is no longer recruiting patients (Current: 23 Nov 2006)
• A Comparative Study of the Outcomes of 2 Surgical Procedures for Safe Type of Chronic Otitis Media - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Prednisone Treatment for Vestibular Neuronitis - This study is currently recruiting patients (Current: 23 Nov 2006) - Prednisone
• Randomized,Investigator-Blind Trial to Evaluate Faropenem Medoxomil in the Treatment of Acute Otitis Media - This study is currently recruiting patients (Current: 23 Nov 2006) - Faropenem Medoximil
• Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays - This study is currently recruiting patients (Current: 23 Nov 2006) - triamcinolone acetonide
• Amoxicillin Clavulanate in Treatment of Acute Otitis Media - This study is currently recruiting patients (Current: 23 Nov 2006) - Augmentin 40 mg/kg/day
• PneuMum: Pneumococcal Vaccination of Australian Indigenous Mothers to See If It Protects Their Babies From Ear Disease - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• TELI COM Telithromycin in Children With Otitis Media - This study is currently recruiting patients (Current: 23 Nov 2006) - Telithromycin,Azithromycin
• Gabapentin for the Treatment of Tinnitus - This study has been terminated (Current: 23 Nov 2006) - Gabapentin (Neurontin)
• Clinical Trial of the "Living Well With Hearing Loss Workshop" - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Using PET-CT to Target and Validate Low-Frequency TMS as Treatment for Tinnitus - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• An Efficacy Study of a Single Dose Treatment of PRO-513 for Subjects Suffering a Migraine Attack - This study is currently recruiting patients (Current: 23 Nov 2006) - PRO-513
• Relationship Between Auto NRT and Behavioural T & C Levels With the Nucleus Freedom Cochlear Implant - This study is currently recruiting patients (Current: 23 Nov 2006)
• Safety and Efficacy of Intratympanic Application of Dexamethasone Via Catheter in Patients With Sudden Hearing Loss - This study is currently recruiting patients (Current: 23 Nov 2006) - Dexamethasone-dihydrogenphosphate (4mg/ml)
• Non-Syndrome Hereditary Hearing Impairment - Gene Mapping: India/Pakistan Protocol - This study is currently recruiting patients (Current: 23 Nov 2006)
• Brain Imaging of Tinnitus - This study is currently recruiting patients (Current: 23 Nov 2006)
• Zmax Pediatric Vs Adult Concentration For The Treatment Of Acute Otitis Media - This study is currently recruiting patients (Current: 23 Nov 2006) - Zmax
• Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to 11 - This study has been completed (Current: 23 Nov 2006)
• A Trial of Point of Care Information in Ambulatory Pediatrics - This study has been completed (Current: 23 Nov 2006)
• Progressive Intervention Program for Tinnitus Management - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Predicting Success With Hearing Aids - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Clinical Applications for Time-Compressed Speech Tests - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• AOM Therapy Trial in Young Children - This study is currently recruiting patients (Current: 23 Nov 2006) - Amoxicillin-clavulanate
• Efficacy Trial of Two Pneumococcal Conjugate Vaccines (PncCRM and PncOMPC) for Prevention of Acute Otitis Media Due to Vaccine Serotypes - This study has been completed (Current: 23 Nov 2006)
• The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Children - This study is currently recruiting patients (Current: 23 Nov 2006)
• Middle Ear Pressure Disregulation After Tympanostomy Tube Insertion - This study is currently recruiting patients (Current: 23 Nov 2006)
• Vestipitant Or Vestipitant/Paroxetine Combination In Subjects With Tinnitus And Hearing Loss - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Vestipitant,Vestipitant + Paroxetine
• Psychophysiological Treatment of Chronic Tinnitus - This study is currently recruiting patients (Current: 23 Nov 2006)
• Neuroanatomy of Reading in Congenital Deafness. - This study is currently recruiting patients (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Ear conditions

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Ear conditions:

• Amoxicillin-clavulanate - AOM Therapy Trial in Young Children - This study is currently recruiting patients (Current: 23 Nov 2006)
• Antihistamine - Acute Otitis Media: Adjuvant Therapy to Improve Outcome - This study has been completed (Current: 23 Nov 2006)
• Augmentin 40 mg/kg/day - Amoxicillin Clavulanate in Treatment of Acute Otitis Media - This study is currently recruiting patients (Current: 23 Nov 2006)
• Azithromycin - TELI COM Telithromycin in Children With Otitis Media - This study is currently recruiting patients (Current: 23 Nov 2006)
• Betahistine 24 mg bid (Betaserc) - Effects of Betaserc on Vestibular Compensation in Patients Suffering From Disabling Meniere's Disease and Having Undergone Vestibular Neurotomy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Botanicals - Nervous System Manipulation and Botanicals for the Treatment of Recurrent Ear Infections in Children - This study has been completed (Current: 23 Nov 2006)
• Corticosteroid - Acute Otitis Media: Adjuvant Therapy to Improve Outcome - This study has been completed (Current: 23 Nov 2006)
• Corticosteroids - Autoimmunity in Inner Ear Disease - This study has been terminated (Current: 23 Nov 2006)
• Dexamethasone-dihydrogenphosphate (4mg/ml) - Safety and Efficacy of Intratympanic Application of Dexamethasone Via Catheter in Patients With Sudden Hearing Loss - This study is currently recruiting patients (Current: 23 Nov 2006)
• Faropenem Medoximil - Randomized,Investigator-Blind Trial to Evaluate Faropenem Medoxomil in the Treatment of Acute Otitis Media - This study is currently recruiting patients (Current: 23 Nov 2006)
• Gabapentin (Neurontin) - Gabapentin for the Treatment of Tinnitus - This study has been terminated (Current: 23 Nov 2006)
• Gabapentin - The Effect of Gabapentin on the Sensation and Impact of Tinnitus - This study has been completed (Current: 23 Nov 2006)
• Hormone Replacement Therapy - HRT - Neural Changes in the Aging Auditory System - This study has been completed (Current: 23 Nov 2006)
• Intratympanic Methylprednisolone - Sudden Hearing Loss Multicenter Treatment Trial - This study is currently recruiting patients (Current: 23 Nov 2006)
• Levofloxacin - A Long-Term Study of the Incidence of Musculoskeletal Disorders in Children Who Have Received Levofloxacin or a Standard Non-Fluoroquinone Therapy for Acute Bacterial Infection - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Levofloxacin - A Study of the Effectiveness and Safety of Levofloxacin in Treating Children With a Rapid and Severe Onset of Infection and Inflammation of the Middle Ear That is Difficult to Treat - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Levofloxacin; Amoxicillin/Clavulanate - Levofloxacin In The Treatment Of Children With Recurrent And/or Persistent Acute Otitis Media - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Methotrexate - Autoimmunity in Inner Ear Disease - This study has been terminated (Current: 23 Nov 2006)
• Montelukast - A Pilot Study to Evaluate the Efficacy of Montelukast in the Treatment of Acute Otitis Media (AOM) in Children - This study has been completed (Current: 23 Nov 2006)
• Oral Prednisone - Sudden Hearing Loss Multicenter Treatment Trial - This study is currently recruiting patients (Current: 23 Nov 2006)
• PRO-513 - An Efficacy Study of a Single Dose Treatment of PRO-513 for Subjects Suffering a Migraine Attack - This study is currently recruiting patients (Current: 23 Nov 2006)
• Prednisone - Prednisone Treatment for Vestibular Neuronitis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Prevenar - Study of Streptococcus Pneumoniae in Nose and Throats of Infants With Acute Otitis Media - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sildenafil - Sildenafil For Meniere's Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sulfamethoxazole-Trimethoprim - Effectiveness of Sulfamethoxazole-Trimethoprim in the Treatment of Chronic Otitis Media - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Telithromycin - Comparative Study to Evaluate the Efficacy and Safety of Telithromycin Given Once Daily Versus Cefuroxime Axetil Given Twice Daily in Children With Middle Ear Infections - This study is currently recruiting patients (Current: 23 Nov 2006)
• Telithromycin - TELI COM Telithromycin in Children With Otitis Media - This study is currently recruiting patients (Current: 23 Nov 2006)
• Triamcinolone Acetonide - Short Term Relief of Eustachian Tube Dysfunction and Serous Otitis Media Using Intranasal Steroid Sprays - This study is currently recruiting patients (Current: 23 Nov 2006)
• Vestipitant + Paroxetine - Vestipitant Or Vestipitant/Paroxetine Combination In Subjects With Tinnitus And Hearing Loss - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Vestipitant - Vestipitant Or Vestipitant/Paroxetine Combination In Subjects With Tinnitus And Hearing Loss - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Zmax - Zmax Pediatric Vs Adult Concentration For The Treatment Of Acute Otitis Media - This study is currently recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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