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Diseases » Edwards Syndrome » Summary

What is Edwards Syndrome?

Contents

Edwards Syndrome: Introduction
Types of Edwards Syndrome
Prognosis
Complications
Prevalence
Other names for Edwards Syndrome
What causes Edwards Syndrome?
What are the symptoms of Edwards Syndrome?
Organs Affected by Edwards Syndrome
Can anyone else get Edwards Syndrome?
How is it treated?
Society issues for Edwards Syndrome
Edwards Syndrome: Introduction

What is Edwards Syndrome?

Edwards Syndrome: A rare inherited genetic disorder where a portion of chromosome 18 is duplicated. Most affected individuals die during the fetal stage and surviving infants have serious defects and tend to live for only a short while.
Edwards Syndrome: A syndrome characterized by the presence of an extra (third) chromosome on an otherwise diploid chromosome 18 associated with a broad spectrum of variable abnormalities consisting of more than 130 individual defects of the craniofacial structures, brain, heart, kidneys, and gut. One-third of newborn infants (weighing about 2300) are premature and two-thirds are female. Fetal abnormalities consist mainly of polyhydramnios, small placenta, and single umbilical artery. Tumors in some cases. Trisomy 18 mosaicism is often associated with normal intelligence and mild phenotype.
Source - Diseases Database

Edwards Syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Edwards Syndrome, or a subtype of Edwards Syndrome, affects less than 200,000 people in the US population.
Source - National Institutes of Health (NIH)

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Edwards Syndrome as a "rare disease".
Source - Orphanet

Edwards Syndrome: Introduction

Types of Edwards Syndrome:

Broader types of Edwards Syndrome:

How many people get Edwards Syndrome?

Prevalance of Edwards Syndrome: 1 per 5,000 - 6,000 newborns are affected by Trisomy 18, Genetics Home Reference website
Prevalance Rate of Edwards Syndrome: approx 1 in 5,000 or 0.02% or 54,400 people in USA [about data]
Incidence (annual) of Edwards Syndrome: 1-in-3000 approximately.
Incidence Rate of Edwards Syndrome: approx 1 in 3,000 or 0.03% or 90,666 people in USA [about data]

How serious is Edwards Syndrome?

Prognosis of Edwards Syndrome: Poor. Often spontaneous abortion, or early death after birth. Mental retardation in those that survive.
Complications of Edwards Syndrome: see complications of Edwards Syndrome

What causes Edwards Syndrome?

Causes of Edwards Syndrome: see causes of Edwards Syndrome

What are the symptoms of Edwards Syndrome?

Symptoms of Edwards Syndrome: see symptoms of Edwards Syndrome

Complications of Edwards Syndrome: see complications of Edwards Syndrome

Can anyone else get Edwards Syndrome?

Inheritance: see inheritance of Edwards Syndrome

Inheritance of genetic conditions: see details in inheritance of genetic diseases.

Edwards Syndrome: Testing

Diagnostic testing: see tests for Edwards Syndrome.

Misdiagnosis: see misdiagnosis and Edwards Syndrome.

How is it treated?

Treatments for Edwards Syndrome: see treatments for Edwards Syndrome
Research for Edwards Syndrome: see research for Edwards Syndrome

Society issues for Edwards Syndrome

Hospitalization statistics for Edwards Syndrome: The following are statistics from various sources about hospitalizations and Edwards Syndrome:

0.001% (95) of hospital consultant episodes were for Edward’s Syndrome and Patau’s Syndrome in England 2002-03 (Hospital Episode Statistics, Department of Health, England, 2002-03)
87% of hospital consultant episodes for Edward’s Syndrome and Patau’s Syndrome required hospital admission in England 2002-03 (Hospital Episode Statistics, Department of Health, England, 2002-03)
26% of hospital consultant episodes for Edward’s Syndrome and Patau’s Syndrome were for men in England 2002-03 (Hospital Episode Statistics, Department of Health, England, 2002-03)
74% of hospital consultant episodes for Edward’s Syndrome and Patau’s Syndrome were for women in England 2002-03 (Hospital Episode Statistics, Department of Health, England, 2002-03)
17% of hospital consultant episodes for Edward’s Syndrome and Patau’s Syndrome required emergency hospital admission in England 2002-03 (Hospital Episode Statistics, Department of Health, England, 2002-03)
9.5 days was the mean length of stay in hospitals for Edward’s Syndrome and Patau’s Syndrome in England 2002-03 (Hospital Episode Statistics, Department of Health, England, 2002-03)
more statistics...»

Organs Affected by Edwards Syndrome:

Organs and body systems related to Edwards Syndrome include:

Chromosomes
Dna
Chromosome 18

Name and Aliases of Edwards Syndrome

Main name of condition: Edwards Syndrome

Class of Condition for Edwards Syndrome: genetic chromosomal (trisomy), genetic-chromosomal-autosomal

Other names or spellings for Edwards Syndrome:

trisomy 18, 18 trisomy, Chromosome 18 trisomy, Trisomy 16-18 (formerly known), Trisomy E (formerly known), Orofaciodigital syndrome, with retinal abnormalities

Trisomy 18, Chromosome 18 trisomy syndrome Source - Diseases Database

18 trisomy, Chromosome 18 trisomy, Trisomy 16-18 (formerly known), Trisomy E (formerly known), Trisomy18, 18 trisomy, Chromosome 18 trisomy, Trisomy 16-18 (formerly known), Trisomy E (formerly known)
Source - Office of Rare Diseases (ORD) of the National Institutes of Health (NIH)