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Radiation therapy is used mainly in the early localized stage of the disease. Total nodal irradiation is generally effective for both nodular and diffuse histologies.
Chemotherapy is most effective with multiple combinations of antineoplastic agents. For example, cyclophosphamide, vincristine, Adriamycin, and prednisone can induce a complete remission in 70% to 80% of patients with nodular histology and in 20% to 55% of patients with diffuse histology. Other combinations — such as methotrexate, bleomycin, Adriamycin, Cytoxan, Oncovin, and prednisone (M-BACOP) — induce prolonged remission and sometimes cure the diffuse form.
In recent years, the development of monoclonal antibodies, specifically rituximab, has provided additional options for the treatment of non-Hodgkin's lymphomas either alone or in combination with traditional chemotherapy regimens. Additionally, radioimmunotherapy for the treatment of these lymphomas has shown promise. Monoclonal antibodies are labeled with beta-emitting isotopes. Currently, ibritumomab tiuxetan is being used alone and in combination with rituximab.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Radiation therapy is used mainly in the early localized stage of the disease. Total nodal irradiation is usually effective for nodular and diffuse histologies.
Chemotherapy is most effective with multiple combinations of antineoplastics; remissions and cures may be induced in this manner. Some cases have required intrathecal chemotherapy. Bone marrow and stem cell transplants have also proved helpful.
Source: Handbook of Diseases, 2003
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