TREATMENTS &
RESEARCH
latest
treatment
information
here.
Dr. Huntley's
Diagnosis
Checklist
See what questions
a doctor would ask.
Causes of Gilbert's Syndrome
Causes of Gilbert's Syndrome: Online Medical Books
16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the causes of Gilbert's Syndrome.
Hyperbilirubinemia:
Causes
(Professional Guide to Diseases (Eighth Edition))
As erythrocytes break down at the end of their neonatal life cycle, hemoglobin (Hb) separates into globin (protein) and heme (iron) fragments. Heme fragments form unconjugated (indirect) bilirubin, which binds with albumin for transport to liver cells to conjugate with glucuronide, forming direct bilirubin. Because unconjugated bilirubin is fat-soluble and can’t be excreted in the urine or bile, it may escape to extravascular tissue, especially fatty tissue and the brain, resulting in hyperbilirubinemia.
This pathophysiologic process may develop when:
❑ certain factors disrupt conjugation and usurp albumin-binding sites, including drugs (such as aspirin, tranquilizers, and sulfonamides) and conditions (such as hypothermia, anoxia, hypoglycemia, and hypoalbuminemia)
❑ decreased hepatic function results in reduced bilirubin conjugation
❑ increased erythrocyte production or breakdown results from hemolytic disorders, or Rh or ABO incompatibility
❑ biliary obstruction or hepatitis results in blockage of normal bile flow
❑ maternal enzymes present in breast milk inhibit the neonate’s glucuronyl-transferase conjugating activity. (See Causes of hyperbilirubinemia, page 986.)
Source: Professional Guide to Diseases (Eighth Edition), 2005
Liver problems may be difficult to avoid when taking HIV medicines. But most problems are relatively mild and do not prevent people with HIV from...
"I authorize the release of any medical or other information necessary to process this claim." Do you recognize these words? You should, if...
Germs are a fact of life and catching an infectious disease like a cold may seem inevitable. But there are simple ways to protect yourself against...
Stress takes its toll by making us anxious, depressed and not able to function as fully as we'd like. What many don't know is that stress can...» Next page: Symptoms of Gilbert's Syndrome
Rate This Website
What do you think about the features of this website? Take our user survey and have your say:
Medical Tools & Articles:
Next articles:
- Symptoms of Gilbert's Syndrome
- Diagnosis of Gilbert's Syndrome
- Signs of Gilbert's Syndrome
- Complications of Gilbert's Syndrome
- Treatments for Gilbert's Syndrome
Tools & Services:
- Bookmark this page
- Take a survey relating to Gilbert's Syndrome
- Symptom Search
- Symptom Checker
- Medical Dictionary
- Give your feedback
Medical Articles:
Forums & Message Boards
Common Health Mistakes
mistakes, errors,
and misdiagnosis
of major diseases.
Symptom
Checker
or many
symptoms
Search Specialists by State and City
