Diagnosis of Gilbert's Syndrome

Gilbert's Syndrome Diagnosis: Book Excerpts

• Diagnosis - Hyperbilirubinemia

Diagnostic Tests for Gilbert's Syndrome: Online Medical Books

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Hyperbilirubinemia: Diagnosis
(Professional Guide to Diseases (Eighth Edition))

CONFIRMING DIAGNOSIS Jaundice and elevated levels of serum bilirubin confirm the diagnosis of hyperbilirubinemia.

Inspection of the neonate in a well-lit room (without yellow or gold lighting) reveals yellowish skin coloration, particularly in the sclerae. Jaundice can be verified by pressing the skin on the cheek or abdomen lightly with one finger, then releasing pressure and observing skin color immediately. Signs of jaundice necessitate measuring and charting serum bilirubin levels every 4 hours. Testing may include direct and indirect bilirubin levels, particularly for pathologic jaundice. Bilirubin levels that are excessively elevated or vary daily suggest a pathologic process.

Identifying the underlying cause of hyperbilirubinemia requires a detailed patient history (including prenatal history), family history (paternal Rh factor, inherited red cell defects), present neonate status (immaturity, infection), and blood testing of the neonate and mother (blood group incompatibilities, Hb levels, direct Coombs’test, hematocrit).

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Source: Professional Guide to Diseases (Eighth Edition), 2005

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