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Treatments for Gilbert's Syndrome
Treatments for Gilbert's Syndrome
The list of treatments mentioned in various sources for Gilbert's Syndrome includes the following list. Always seek professional medical advice about any treatment or change in treatment plans.
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Hyperbilirubinemia:
Treatment
(Professional Guide to Diseases (Eighth Edition))
Depending on the underlying cause, treatment may include phototherapy, exchange transfusions, albumin infusion and, possibly, drug therapy. Phototherapy is the treatment of choice for physiologic jaundice, and pathologic jaundice due to erythroblastosis fetalis (after the initial exchange transfusion). Phototherapy uses fluorescent light to decompose bilirubin in the skin by oxidation and is usually discontinued after bilirubin levels fall below 10 mg/dl and continue to decrease for 24 hours. However, phototherapy is rarely the only treatment for jaundice due to a pathologic cause.
An exchange transfusion replaces the neonate’s blood with fresh blood (less than 48 hours old), removing some of the unconjugated bilirubin in serum. Possible indications for exchange transfusions include hydrops fetalis, polycythemia, erythroblastosis fetalis, marked reticulocytosis, drug toxicity, and jaundice that develops within the first 6 hours after birth.
Other therapy for excessive bilirubin levels may include albumin administration (1 g/kg of 25% salt-poor albumin), which provides additional albumin for binding unconjugated bilirubin. This may be done 1 to 2 hours before exchange or as a substitute for a portion of the plasma in the transfused blood.
Drug therapy, which is rare, usually consists of phenobarbital administered to the mother before delivery and to the neonate several days after delivery. This drug stimulates the hepatic glucuronide-conjugating system.
Source: Professional Guide to Diseases (Eighth Edition), 2005
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