Prevalence and Incidence of Goodpasture syndrome

Prevalance of Goodpasture syndrome:

rare. ... see also overview of Goodpasture syndrome.

Goodpasture syndrome: Rare Disease

Goodpasture syndrome is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Goodpasture syndrome, or a subtype of Goodpasture syndrome, affects less than 200,000 people in the US population.

Ophanet, who are a consortium of European partners, currently defines a condition rare when if affects 1 person per 2,000. They list Goodpasture syndrome as a "rare disease". More information about Goodpasture syndrome is available from Orphanet

Goodpasture syndrome Prevalence: Book Excerpts

• Causes and incidence - Goodpasture's syndrome
• Causes and incidence - Allergic purpuras
• Causes and incidence - Idiopathic thrombocytopenic purpura
• Causes and incidence - Premature rupture of membranes
• Purpura Fulminans - epidemiology - Purpura Fulminans

Prevalence/Incidence of Goodpasture syndrome: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the prevalence and/or incidence of Goodpasture syndrome.

Goodpasture's syndrome: Causes and incidence
(Professional Guide to Diseases (Eighth Edition))

The cause of Goodpasture’s syndrome is unknown. Although some cases have been associated with exposure to hydrocarbons or type 2 influenza, many have no precipitating events. The high incidence of human leukocyte antigen DRW2 in these patients suggests a genetic predisposition. Abnormal production and deposition of antibody against GBM and alveolar basement membrane activate the complement and inflammatory responses, resulting in glomerular and alveolar tissue damage.

This syndrome may occur at any age but is most common in males between ages 20 and 30. A second peak incidence occurs between ages 50 and 70, with males and females in this age group affected equally.

» READ BOOK EXCERPT ONLINE »

Source: Professional Guide to Diseases (Eighth Edition), 2005

Allergic purpuras: Causes and incidence
(Professional Guide to Diseases (Eighth Edition))

The most common identifiable cause of allergic purpura is probably an autoimmune reaction directed against vascular walls, triggered by a bacterial infection (particularly streptococcal infection). Typically, upper respiratory tract infection occurs 1 to 3 weeks before the onset of symptoms. Other possible causes include allergic reactions to some drugs and vaccines, to insect bites, and to some foods (such as wheat, eggs, milk, and chocolate).

Allergic purpura affects more males than females and is most prevalent in children ages 3 to 7. The prognosis is more favorable for children than adults.

» READ BOOK EXCERPT ONLINE »

Source: Professional Guide to Diseases (Eighth Edition), 2005

Idiopathic thrombocytopenic purpura: Causes and incidence
(Professional Guide to Diseases (Eighth Edition))

ITP may be an autoimmune disorder, because antibodies that reduce the life span of platelets have been found in nearly all patients. The spleen probably helps to remove platelets modified by the antibody. Acute ITP usually follows a viral infection, such as rubella or chickenpox, and can follow immunization with a live virus vaccine. Chronic ITP seldom follows infection and is commonly linked to immunologic disorders such as systemic lupus erythematosus. It’s also linked to drug reactions. ITP frequently occurs in patients who have abused alcohol, heroin, or morphine, and in patients with acquired immunodeficiency syndrome who are exposed to the rubella virus.

Acute ITP usually affects children between ages 2 and 6; chronic ITP mainly affects adults younger than age 50, especially women between ages 20 and 40.

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Source: Professional Guide to Diseases (Eighth Edition), 2005

Premature rupture of membranes: Causes and incidence
(Professional Guide to Diseases (Eighth Edition))

Although the cause of PROM is unknown, malpresentation and contracted pelvis commonly accompany the rupture. Predisposing factors may include:

❑ poor nutrition and hygiene, and lack of proper prenatal care

❑ incompetent cervix (perhaps as a result of abortions)

❑ increased intrauterine tension due to hydramnios or multiple pregnancies

❑ defects in the amniochorial membranes’ tensile strength

❑ uterine infection.

PROM occurs in nearly 10% of all pregnancies over 20 weeks’ gestation.

» READ BOOK EXCERPT ONLINE »

Source: Professional Guide to Diseases (Eighth Edition), 2005

Purpura Fulminans: Purpura Fulminans - epidemiology
(The 5-Minute Pediatric Consult)

Depends on underlying cause

Purpura Fulminans - incidence

• Neonatal purpura fulminans related to homozygous protein C deficiency: 1 in 250,000–500,000 births
• Homozygous protein S deficiency is more rare.

Purpura Fulminans - prevalence

Purpura frequently seen in bacterial sepsis with meningococcus and other pathogens

» READ BOOK EXCERPT ONLINE »

Source: The 5-Minute Pediatric Consult, 2008

About prevalence and incidence statistics:

The term 'prevalence' of Goodpasture syndrome usually refers to the estimated population of people who are managing Goodpasture syndrome at any given time. The term 'incidence' of Goodpasture syndrome refers to the annual diagnosis rate, or the number of new cases of Goodpasture syndrome diagnosed each year. Hence, these two statistics types can differ: a short-lived disease like flu can have high annual incidence but low prevalence, but a life-long disease like diabetes has a low annual incidence but high prevalence. For more information see about prevalence and incidence statistics.

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