Following is a list of causes or underlying conditions (see also Misdiagnosis of underlying causes of Gout) that could possibly cause Gout includes:
The follow list shows some of the possible medical causes of Gout that are listed by the Diseases Database:
Source: Diseases DatabaseOther conditions that might have Gout as a complication may, potentially, be an underlying cause of Gout. Our database lists the following as having Gout as a complication of that condition:
Conditions listing Gout as a symptom may also be potential underlying causes of Gout. Our database lists the following as having Gout as a symptom of that condition:
The following drugs, medications, substances or toxins are some of the possible
causes of Gout as a symptom.
This list is incomplete and various other drugs or substances
may cause your symptoms.
Always advise your doctor of any medications or treatments you are using,
including prescription, over-the-counter, supplements, herbal or alternative treatments.
See full list of 37 medications causing Gout
When combined, certain drugs, medications, substances or toxins may react causing Gout as a symptom.
The list below is incomplete and various other drugs or substances may cause your symptoms. Always advise your doctor of any medications or treatments you are using, including prescription, over-the-counter, supplements, herbal or alternative treatments.
See full list of 48 drug interactions causing Gout
Causes: Gout:
Deposits of uric acid crystals in the joints.
The following conditions are listed as possible triggers for Gout:
As with all medical conditions, there may be many causal factors. Further relevant information on causes of Gout may be found in:
16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the causes of Gout.
Although the exact cause of primary gout remains unknown, it appears to be linked to a genetic defect in purine metabolism, which causes elevated blood levels of uric acid (hyperuricemia) due to overproduction of uric acid, retention of uric acid, or both. In secondary gout, which develops during the course of another disease (such as obesity, diabetes mellitus, hypertension, sickle cell anemia, and renal disease), hyperuricemia results from the breakdown of nucleic acids. Myeloproliferative and lymphoproliferative diseases, psoriasis, and hemolytic anemia are the most common causes. Primary gout usually occurs in men and in postmenopausal women; secondary gout occurs in elderly people.
Secondary gout can also follow drug therapy that interferes with uric acid excretion. Increased concentration of uric acid leads to urate deposits (tophi) in joints or tissues and consequent local necrosis or fibrosis. The risk is greater in men, postmenopausal women, and those who use alcohol.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Neurogenic arthropathy is most common in men older than 40 years. In adults, the most common cause of neurogenic arthropathy is diabetes mellitus. Other causes include tabes dorsalis (especially among patients age 40 to 60), syringomyelia (progresses to neurogenic arthropathy in about 25% of patients),myelopathy of pernicious anemia, spinal cord trauma, paraplegia, hereditary sensory neuropathy, and Charcot-Marie-Tooth disease. Amyloidosis, peripheral nerve injury, myelomeningocele (in children), leprosy, and alcoholism may cause neurogenic arthropathy, but only in rare occurrences.
Frequent intra-articular injection of corticosteroids has also been linked to neurogenic arthropathy. The analgesic effect of the corticosteroids may mask symptoms and allow continuous stress to accelerate joint destruction.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Although the exact cause of primary gout remains unknown, it seems linked to a genetic defect in purine metabolism, which causes overproduction of uric acid (hyperuricemia), retention of uric acid, or both.
In secondary gout, which develops during the course of another disease (such as obesity, diabetes mellitus, hypertension, sickle cell anemia, and renal disease), hyperuricemia results from the breakdown of nucleic acid.
Secondary gout can also follow drug therapy, especially the use of hydrochlorothiazide or pyrazinamide, which interferes with urate excretion. An increased concentration of uric acid leads to urate deposits, called tophi, in joints or tissues, causing local necrosis or fibrosis.
Another condition — pseudogout — results when calcium pyrophosphate crystals collect in the periarticular joint structures. (See Pseudogout, page 348.)
Source: Handbook of Diseases, 2003
In adults, the most common cause of neurogenic arthropathy is diabetes mellitus. Other causes include tabes dorsalis (especially among patients ages 40 to 60), syringomyelia (which progresses to neurogenic arthropathy in about 25% of patients), myelopathy of pernicious anemia, spinal cord trauma, paraplegia, hereditary sensory neuropathy, and Charcot-Marie-Tooth disease. Rarely, amyloidosis, peripheral nerve injury, myelomeningocele (in children), leprosy, or alcoholism causes neurogenic arthropathy.
Frequent intra-articular injections of a corticosteroid have also been linked to neurogenic arthropathy. The analgesic effect of the corticosteroid may mask symptoms and allow continuous damaging stress to accelerate joint destruction.
Source: Handbook of Diseases, 2003
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