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Thyrotoxicosis

Thyrotoxicosis: Excerpt from A Pocket Manual of Differential Diagnosis

Thyrotoxicosis with high or normal radioactive iodine uptake
Abnormal thyroid stimulator
   Human chorionic gonadotropin (HCG)
       Gestational thyrotoxicosis (with hyperemesis)
       Tumors secreting HCG
          Choriocarcinoma
          Hydatidiform mole
          Embryonal cell carcinoma of the testis
   Thyroid-stimulating hormone (TSH)
       Selective pituitary resistance to thyroid hormone
       TSH-secreting pituitary adenoma
   Thyroid-stimulating immunoglobulins
       Graves' disease
       Hashitoxicosis
       Neonate of mother with Graves' disease
Autonomous thyroid function
   Constitutive activation of TSH receptors (autosomal
dominant)
   Toxic adenoma
   Toxic multinodular goiter
Postaspiration thyrotoxicosis (after needle aspirate of
thyroid cyst)
TSH hyperresponsiveness (autosomal dominant)

Thyrotoxicosis with a Low Radioactive Iodine Uptake

Excessive thyroidal production of thyroid hormone
   Iodine-induced thyrotoxicosis (the “jod-Basedow”
phenomenon)
       Amiodarone
       Other iodine-containing drugs
       Iodine-containing x-ray contrast agents
Extrathyroidal sources of thyroid hormone
   Ectopic thyroid tissue
       Metastatic differentiated thyroid cancer
       Struma ovarii
   Hormone ingestion
       “Hamburger thyrotoxicosis”

       Iatrogenic
       Thyrotoxicosis factitia
Inflammation of the thyroid
   Drug-induced thyroiditis
       Amiodarone
   Interferon-α

       Interleukin-2
   Infarction of thyroid adenoma
   Postpartum thyroiditis
   Radiation thyroiditis
   Silent (painless) thyroiditis
   Subacute (DeQuervain's, granulomatous) thyroiditis
Postparathyroidectomy thyrotoxicosis (transient—2 weeks)

References

1. Burman KD: Hyperthyroidism, pp. 371–376. See Bibliography, 2.
2. Braverman LE, Utiger RD: Introduction to Thyrotoxicosis, pp. 522–524. See Bibliography, 4.

Book Source Details

• Book Title: A Pocket Manual of Differential Diagnosis
• Author(s): Stephen N. Adler, Dianne B. Gasbarra
• Year of Publication: 1999
• Copyright Details: A Pocket Manual of Differential Diagnosis, Copyright © 1999 Lippincott Williams & Wilkins.

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Copyright notice for book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.

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More About This Book: Title: A Pocket Manual of Differential Diagnosis Authors: Stephen N. Adler, Dianne B. Gasbarra Publisher: Lippincott Williams & Wilkins Copyright: 1999 ISBN: 0-78171-943-7

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