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Diseases » Graves Disease » Prevalence
 

Prevalence and Incidence of Graves Disease

Prevalance of Graves Disease:

3,048,636 people in the USA 1996 1; 1.3 million people (NWHIC) ... see also overview of Graves Disease.

Prevalance Rate:

approx 1 in 89 or 1.12% or 3 million people in USA [Source statistic for calcuation: "3,048,636 people in the USA 1996 1; 1.3 million people (NWHIC)" -- see also general information about data sources]

Graves Disease Prevalence: Book Excerpts

Incidence (annual) of Graves Disease:

about 5 per 10,000 people (NWHIC) ... see also overview of Graves Disease.

Incidence Rate:

approx 1 in 2,000 or 0.05% or 136,000 people in USA [Source statistic for calcuation: "about 5 per 10,000 people (NWHIC)" -- see also general information about data sources]

Incidence extrapolations for USA for Graves Disease:

136,000 per year, 11,333 per month, 2,615 per week, 372 per day, 15 per hour, 0 per minute, 0 per second. [Source statistic for calculation: "about 5 per 10,000 people (NWHIC)" -- see also general information about data sources]

Incidence of Graves Disease:

The incidence is about 5 in 10,000 people. (Source: excerpt from Graves' Disease: NWHIC)

Prevelance statistics for Graves Disease:

The following statistics relate to the prevalence of Graves Disease:

  • 1 million cases of Graves' Disease in the US (NIH, The National Women’s Health Centre, 2004)
  • Graves' Disease 4 to 8 times more common in women than men in the US (NIH, The National Women’s Health Centre, 2004)
  • more statistics...»

Prevalence/Incidence of Graves Disease: Online Medical Books

16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the prevalence and/or incidence of Graves Disease.

Simple goiter: Causes and incidence
(Professional Guide to Diseases (Eighth Edition))

Simple goiter occurs when the thyroid gland can’t secrete enough thyroid hormone to meet metabolic requirements. As a result, the thyroid gland enlarges to compensate for inadequate hormone synthesis, a compensation that usually overcomes mild to moderate hormonal impairment. Because thyroid-stimulating hormone (TSH) levels are generally within normal limits in patients with simple goiter, goitrogenicity probably results from impaired intrathyroidal hormone synthesis and depletion of glandular iodine, which increases the thyroid gland’s sensitivity to TSH. However, increased levels of TSH may be transient and therefore missed.

Endemic goiter usually results from inadequate dietary intake of iodine, which leads to inadequate secretion of thyroid hormone. Since the introduction of iodized salt in the United States, cases of endemic goiter have virtually disappeared.

Sporadic goiter commonly results from the ingestion of large amounts of goitrogenic foods or the use of goitrogenic drugs. Goitrogenic foods, such as rutabagas, cabbage, soybeans, peanuts, peaches, peas, strawberries, spinach, and radishes, contain agents that decrease thyroxine (T4) production. Goitrogenic drugs include propylthiouracil, iodides, phenylbutazone, para-aminosalicylic acid, cobalt, and lithium. In a pregnant woman, these substances may cross the placenta and affect the fetus.

Inherited defects may be responsible for insufficient T4 synthesis or impaired iodine metabolism. Because families tend to congregate in a single geographic area, this familial factor may contribute to the incidence of both endemic and sporadic goiters.

Females are more commonly affected than males. Incidence increases after age 40.  

» READ BOOK EXCERPT ONLINE »

Source: Professional Guide to Diseases (Eighth Edition), 2005

Hyperthyroidism: Causes and incidence
(Professional Guide to Diseases (Eighth Edition))

Hyperthyroidism may result from both genetic and immunologic factors. An increased incidence of this disorder in monozygotic twins, for example, points to an inherited factor, probably an autosomal recessive gene. This disease occasionally coexists with abnormal iodine metabolism and other endocrine abnormalities, such as diabetes mellitus, hyperparathyroidism, and thyroiditis. Hyperthyroidism is also associated with autoantibody production (thyroid-stimulating immunoglobulin and thyroid-stimulating hormone [TSH]-binding inhibitory immunoglobulin), possibly due to a defect in suppressor–T-lymphocyte function that allows the formation of autoantibodies.

In latent hyperthyroidism, excessive dietary intake of iodine and, possibly, stress can precipitate clinical hyperthyroidism. In a person with inadequately treated hyperthyroidism, stress — including surgery, infection, toxemia of pregnancy, and diabetic ketoacidosis — can precipitate thyroid storm. (See Other forms of hyperthyroidism.)

Incidence of Graves’ disease is highest between ages 30 and 40, especially in people with family histories of thyroid abnormalities; only 5% of hyperthyroid patients are younger than age 15.

» READ BOOK EXCERPT ONLINE »

Source: Professional Guide to Diseases (Eighth Edition), 2005

Goiter: Goiter - epidemiology
(The 5-Minute Pediatric Consult)

  • The most common cause of pediatric goiter in the US is chronic lymphocytic thyroiditis.
  • Prevalence of goiter in the US is 3–7%, although the incidence is much higher in regions of iodine deficiency.
  • Thyroid cancers comprise 0.5–1.5% of all malignancies in children and adolescents.
  • Thyroid tumors and autoimmune thyroid disease are both more common in females than in males.

Goiter - prevalence

World Health Organization (WHO) Global Database on Iodine Deficiency (1993–2003)

  • Global goiter prevalence is 15.8% of the general population.
  • Insufficient iodine intake among school-aged children ranged from 10.1% in the Americas to 59.9% in Europe.
  • 54 countries had iodine deficiency, 29 countries had excessive iodine intake, and 43 countries achieved optimal iodine intake.

» READ BOOK EXCERPT ONLINE »

Source: The 5-Minute Pediatric Consult, 2008

About prevalence and incidence statistics:

The term 'prevalence' of Graves Disease usually refers to the estimated population of people who are managing Graves Disease at any given time. The term 'incidence' of Graves Disease refers to the annual diagnosis rate, or the number of new cases of Graves Disease diagnosed each year. Hence, these two statistics types can differ: a short-lived disease like flu can have high annual incidence but low prevalence, but a life-long disease like diabetes has a low annual incidence but high prevalence. For more information see about prevalence and incidence statistics.

Footnotes:
1. Rose and Mackay, 1998, The Autoimmune Diseases, Third Edition


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