As with all medical conditions, there may be many causal factors. Further relevant information on causes of Hemophilia may be found in:
16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the causes of Hemophilia.
Both hemophilia A and B are inherited as X-linked recessive traits. This means that female carriers have a 50% chance of transmitting the gene to each daughter, who would then be a carrier, and a 50% chance of transmitting the gene to each son, who would be born with hemophilia. Hemophilia A (classic hemophilia), which affects more than 80% of patients with hemophilia, results from a deficiency of factor VIII-C; hemophilia B (Christmas disease), which affects approximately 15% of patients with hemophilia, results from a deficiency of factor IX-C.
The factor VIII gene is located within the Xq28 region, and the factor IX gene is located within Xq27. Females with one defective factor VIII gene are carriers of hemophilia. A large number of disease-causing mutations have been identified in both genes. A specific inversion mutation in the noncoding region of the factor VIII gene is present in approximately 45% of families with severe hemophilia A. Hemophilia A is the most common X-linked genetic disease, occurring in approximately 1 in 10,000 live male births. It is five times more common than hemophilia B.
Source: Professional Guide to Diseases (Eighth Edition), 2005
Hemophilia is caused by a deficiency of clotting factors that are genetically transmitted. (See X factor.)
Hemophilia is the most common X-linked genetic disease, occurring in about 1.25 in 10,000 live male births. Hemophilia A is five times more common than hemophilia B. Hemophilia causes abnormal bleeding because of a specific clotting factor malfunction. After a person with hemophilia forms a platelet plug at a bleeding site, clotting factor deficiency impairs the capacity to form a stable fibrin clot.
Source: Handbook of Diseases, 2003
What do you think about the features of this website? Take our user survey and have your say:
Next articles:
Tools & Services:
Medical Articles:
Search Specialists by State and City
By using this site you agree to our Terms of Use. Information provided on this site is for informational purposes only; it is not intended as a substitute for advice from your own medical team. The information on this site is not to be used for diagnosing or treating any health concerns you may have - please contact your physician or health care professional for all your medical needs. Please see our Terms of Use.
Copyright © 2009 Health Grades Inc. All rights reserved.
In recent years, the drug Rituxan has become a well-established option only for certain forms of non-Hodgkin's lymphoma (NHL) There are other...
Whenever you go to a hospital or clinic for a major procedure or diagnostic test, one of the many forms you are given to sign is an "informed...
Germs are a fact of life and catching an infectious disease like a cold may seem inevitable. But there are simple ways to protect yourself against...
Sexual contact can sometimes result in problems. An unwanted pregnancy or sexually transmitted diseases may be some of those consequences. But by...