Diseases » Hereditary Spastic Paraplegia

Paralysis and Paresis

Paralysis and Paresis: Excerpt from A Pocket Manual of Differential Diagnosis

Acute (Developing in Hours)

Spinal cord injury
Spinal cord hemorrhage (secondary to vascular malformation, coagulopathy, anticoagulant therapy, trauma)
Spinal cord infarct (secondary to spinal artery thrombosis, embolism, vasculitis)
Dissecting aortic aneurysm
Aortic thrombosis
Acute necrotizing myelitis
Profound hypokalemia (serum K⁺ <2.5 mEq/L)
Hyperkalemic or hypokalemic periodic paralysis
Hypermagnesemia

Subacute (Developing in Days)

Guillain-Barré syndrome
Myelitis
   Viral (especially polio, rabies, herpes zoster)
   Postinfectious (especially after measles, smallpox, chickenpox)
   Subacute pyogenic meningomyelitis
   Tuberculous meningomyelitis
   Acute demyelinating myelitis (e.g., multiple sclerosis)
   Acute necrotizing myelitis
Rhabdomyolysis
   Crush injury
   Excessive muscular activity
   Muscle infarction secondary to prolonged pressure and ischemia
   Polymyositis, viral or idiopathic
Diphtheritic polyneuropathy
Botulism
Spinal cord or epidural abscess
Spinal cord compression (e.g., secondary to tumor)

Slow (Developing over Weeks to Months)

Severe peripheral neuropathy
Multiple cerebrovascular accidents (bilateral hemiplegia)
Polymyositis
   Infection-associated
       Viral infection
       Syphilis
       Tuberculosis
       Toxoplasmosis, other protozoan or fungal infections
       Trichinosis, other helminthic infections
   Associated with connective-tissue disease (e.g., systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome)
   Associated with carcinoma
   Idiopathic
Cervical spondylosis
Ankylosing spondylitis
Paget's disease
Pott's disease
Subacute combined degeneration of the spinal cord
Neurosyphilis (syphilitic meningomyelitis, tabes dorsalis)
Spinal arachnoiditis (e.g., after subarachnoid hemorrhage, meningitis, subarachnoid space injection)
Chronic epidural infection or granuloma (e.g., tuberculous, parasitic, fungal)
Electrical or radiation injury of spinal cord
Multiple sclerosis
Syringomyelia
Amyotrophic lateral sclerosis

Childhood (or Young Adulthood) Onset

Congenital
   Cerebral spastic diplegia
   Anomalies of spinal cord or vertebrae
Hereditary disease
   Werdnig-Hoffmann disease
   Muscular dystrophies
   Friedreich's ataxia
   Chronic polyneuropathies
   Niemann-Pick disease
   Tay-Sachs disease

References

1. Clacy RK, Aminoff MJ: Weakness, Abnormal Movements and Imbalance, p. 107. See Bibliography, 5.
2. Sweeney VP: Approach to the Patient with Sensory Loss and Weakness, p. 2361. See Bibliography, 3. >

Book Source Details

• Book Title: A Pocket Manual of Differential Diagnosis
• Author(s): Stephen N. Adler, Dianne B. Gasbarra
• Year of Publication: 1999
• Copyright Details: A Pocket Manual of Differential Diagnosis, Copyright © 1999 Lippincott Williams & Wilkins.

More About Hereditary Spastic Paraplegia

• Back to disease: Hereditary Spastic Paraplegia: Introduction
• Next Book Extract About Hereditary Spastic Paraplegia: Vocal cord paralysis (Professional Guide to Diseases (Eighth Edition))
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Copyright notice for book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.

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More About This Book: Title: A Pocket Manual of Differential Diagnosis Authors: Stephen N. Adler, Dianne B. Gasbarra Publisher: Lippincott Williams & Wilkins Copyright: 1999 ISBN: 0-78171-943-7

 » Next page: Vocal cord paralysis (Professional Guide to Diseases (Eighth Edition))

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