Causes of Hodgkin's Disease
Hodgkin's Disease Causes: Book Excerpts
Hodgkin's Disease as a complication of other conditions:
Other conditions that might have
Hodgkin's Disease as a complication may,
potentially, be an underlying cause of Hodgkin's Disease.
Our database lists the following as having
Hodgkin's Disease as a complication of that condition:
What causes Hodgkin's Disease?
Causes: Hodgkin's Disease:
Cancerous over-growth of lymphatic tissue
Article excerpts about the
causes of Hodgkin's Disease:
What You Need To Know About Hodgkin's Disease: NCI (Excerpt)
In Hodgkin's disease, cells in the lymphatic system become
abnormal. They divide too rapidly and grow without any order
or control. Because lymphatic tissue is present in many parts
of the body, Hodgkin's disease can start almost anywhere.
Hodgkin's disease may occur in a single lymph node, a group of
lymph nodes, or, sometimes, in other parts of the lymphatic
system such as the bone marrow and spleen. This type of cancer
tends to spread in a fairly orderly way from one group of
lymph nodes to the next group. For example, Hodgkin's disease
that arises in the lymph nodes in the neck spreads first to
the nodes above the collarbones, and then to the lymph nodes
under the arms and within the chest. Eventually, it can spread
to almost any other part of the body. (Source: excerpt from What You Need To Know About Hodgkin's Disease: NCI)
What You Need To Know About Hodgkin's Disease: NCI (Excerpt)
It is clear, however, that
Hodgkin's disease is not caused by an injury, and it is not
contagious; no one can "catch" this disease from another
person. (Source: excerpt from What You Need To Know About Hodgkin's Disease: NCI)
Related information on causes of Hodgkin's Disease:
As with all medical conditions,
there may be many causal factors.
Further relevant information on causes of Hodgkin's Disease may be found in:
Causes of Hodgkin's Disease: Online Medical Books
16 MEDICAL BOOKS ONLINE!
Review excerpts from medical books online, free, without registration,
for more information about the causes of Hodgkin's Disease.
Hodgkin's disease:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
Although the cause of Hodgkin's disease is unknown, a viral etiology is suspected, with the Epstein-Barr virus as a leading candidate. The disease is most common in young adults, with a higher incidence in males than in females. It occurs in all races but is slightly more common in whites. Its incidence peaks in two age-groups: 15 to 38 and after age 50 — except in Japan, where it occurs exclusively among people older than 50.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Non-Hodgkin's lymphoma:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
The cause of non-Hodgkin's lymphoma is unknown, although some theories suggest a viral source. Since the early 1970s, the incidence of these lymphomas has increased more than 80%, with about 53,000 new cases appearing annually in the United States. The reason for the increase is unknown, although it has been partly attributed to acquired immunodeficiency syndrome. Non-Hodgkin's lymphomas are two to three times more common in males than in females and occur in all age-groups. Compared to Hodgkin's disease, they occur about one to three times more often and cause twice as many deaths in children younger than age 15. Incidence rises with age (median age is 50). These lymphomas seem linked to certain races and ethnic groups, with increased incidence in whites and people of Jewish ancestry.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Lymphomas, malignant:
Causes
(Handbook of Diseases)
The cause of malignant lymphomas is unknown, although some theories suggest a viral source. Up to 35,000 new cases appear annually in the United States. Malignant lymphomas are two to three times more common in males than in females and occur in all age-groups.
Although rare in children, these lymphomas occur one to three times more often and cause twice as many deaths as Hodgkin’s disease in children under age 15. Incidence rises with age (median age is 50). Malignant lymphomas seem linked to certain races and ethnic groups, with increased incidence in whites and people of Jewish ancestry.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Hodgkin's disease:
Causes
(Handbook of Diseases)
The cause of Hodgkin’s disease is unknown. This disease is most common in young adults and occurs more commonly in men than in women. It occurs in all races but is slightly more common in whites. Incidence peaks in two age-groups: ages 15 to 38 and after age 50, except in Japan, where it occurs exclusively among people over age 50.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Hodgkin Lymphoma:
Hodgkin Lymphoma - risk factors
(The 5-Minute Pediatric Consult)
Risk groups:
- Low risk: IA-IIA, without bulk disease
- Intermediate risk:
- IA-IIA with bulk disease (defined by nodal aggregate >6 cm or mediastinal mass > 1/3 the thoracic diameter)
- IAE, IIAE: IB-IIB
- IIIA, IVA
- High risk: IIIB, IVB
- Prognostic factors:
- Disease stage
- Presence of B symptoms
- Bulk disease or mediastinal mass
- Laboratory abnormalities including hemoglobin (Hb) <11 g/dL, WBC >13.5 cc/mm3, elevated ESR
- Timing of response to treatment
>
» READ BOOK EXCERPT ONLINE »
Source: The 5-Minute Pediatric Consult, 2008
Non Hodgkin Lymphoma:
Non Hodgkin Lymphoma - pathophysiology
(The 5-Minute Pediatric Consult)
In contrast to adult lymphomas, childhood NHL is almost never nodular alone and rarely occurs in peripheral nodal areas.
Pediatric NHL can be divided into 3 major categories according to the National Cancer Institute (NCI) formulation:
- Small noncleaved-cell lymphomas (B cell):
- 40% of childhood NHL
- Subdivided into Burkitt and non-Burkitt based on the degree of pleomorphism
- A variety of B-cell markers is usually present (e.g., CALLA, CD20).
- Expresses surface immunoglobulins (Ig), most bearing IgM of either κ or λ light-chain subtype
- Terminal deoxyribonucleotidyl transferase (TdT) is negative.
- Characteristic chromosomal translocation, usually t(8;14), rarely t(8;22) or t(2;8); all translocations involve the c-myc proto-oncogene.
- Lymphoblastic lymphomas:
- Comprise 30% of childhood NHL
- In children, 90% T-cell and 10% B-cell origin
- Predominantly of thymocyte (T-cell) origin: Morphologically identical to acute leukemia T lymphoblasts. Bone marrow involvement of >25% blasts is considered leukemia.
- T-cell lymphomas are positive for TdT and have a T-cell immunophenotype (e.g., CD7).
- Most lack chromosomal translocations and seldom involve T-cell receptor genes on chromosomes 7 and 14q.
- Large-cell lymphomas:
- 30% of childhood NHL
- 2/3 are a large noncleaved or cleaved type of B-cell origin; these can be diffuse large B-cell lymphoma (DLBCL) or mediastinal large cell lymphoma (LCLM).
- 1/3 are anaplastic large cell lymphoma (ALCL) and are positive for CD30 (Ki-1).
- ALK (anaplastic lymphoma kinase) positivity seen in systemic ALCL disease; ALK negative more often localized/cutaneous ALCL. ALK negative is rare in children.
Non Hodgkin Lymphoma - etiology
Unknown
» READ BOOK EXCERPT ONLINE »
Source: The 5-Minute Pediatric Consult, 2008
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» Next page: Risk Factors for Hodgkin's Disease
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