Hyper-IgM Syndrome

Introduction: Hyper-IgM Syndrome

Hyper-IgM Syndrome: Immunodeficiency with hyper-IgM (HIM) is a rare primary immunodeficiency characterized by the production of normal to increased amounts of IgM antibody of ... more about Hyper-IgM Syndrome.

Hyper-IgM Syndrome: A rare inherited immunodeficiency disorder which causes frequent infections involving the ears, eyes, sinuses, lungs, skin, respiratory tract and other areas of the body. More detailed information about the symptoms, causes, and treatments of Hyper-IgM Syndrome is available below.

Symptoms of Hyper-IgM Syndrome

• Recurring respiratory infections
• Enlarged tonsils
• Enlarged liver
• Enlarged spleen
• Chronic diarrhea

See full list of 21 symptoms of Hyper-IgM Syndrome

Medical Textbooks Online about Hyper-IgM Syndrome

Book excerpts: Copyright © 2008 Lippincott Williams & Wilkins. All rights reserved.

Diagnostic Tests for Hyper-IgM Syndrome

• Immune function blood tests
• IgA levels
• IgG levels

Read more about tests for Hyper-IgM Syndrome

Wrongly Diagnosed with Hyper-IgM Syndrome?

• Misdiagnosis of Hyper-IgM Syndrome

Causes of Hyper-IgM Syndrome

Read more about causes of Hyper-IgM Syndrome.

Treatments for Hyper-IgM Syndrome

• Intravenous immunogloblulin (IVIG)
• Granulocyte colony-stimulating factor (G-CSF) - for neutropenia
• Antibiotics - for infections or preventive maintenance.

Read more about treatments for Hyper-IgM Syndrome

Videos for Hyper-IgM Syndrome

Patient Surveys for Hyper-IgM Syndrome

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Reseach about Hyper-IgM Syndrome

Visit our research pages for current research about Hyper-IgM Syndrome treatments.

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User Interactive Forums

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Article Excerpts about Hyper-IgM Syndrome

Genes and Disease by the National Center for Biotechnology (Excerpt)

Immunodeficiency with hyper-IgM (HIM) is a rare primary immunodeficiency characterized by the production of normal to increased amounts of IgM antibody of questionable quality and an inability to produce sufficient quantities of IgG and IgA. Individuals with HIM are susceptible to recurrent bacterial infections and are at an increased risk of autoimmune disorders and cancer at an early age. (Source: Genes and Disease by the National Center for Biotechnology)

Primary Immune Deficiency, NIAID Fact Sheet: NIAID (Excerpt)

Hyper-IgM is a rare immunodeficiency disease in which the immune system fails to produce IgA and IgG antibodies. (Source: excerpt from Primary Immune Deficiency, NIAID Fact Sheet: NIAID)

Definitions of Hyper-IgM Syndrome:

Ophanet, a consortium of European partners, currently defines a condition rare when it affects 1 person per 2,000. They list Hyper-IgM Syndrome as a "rare disease".
Source - Orphanet