Causes of Hypopituitarism
Causes of Hypopituitarism (Diseases Database):
The follow list shows some of the possible medical causes of Hypopituitarism
that are listed by the Diseases Database:
Source: Diseases Database
Hypopituitarism Causes: Book Excerpts
Hypopituitarism as a complication of other conditions:
Other conditions that might have
Hypopituitarism as a complication may,
potentially, be an underlying cause of Hypopituitarism.
Our database lists the following as having
Hypopituitarism as a complication of that condition:
Hypopituitarism as a symptom:
Conditions listing Hypopituitarism
as a symptom may also be potential underlying causes of Hypopituitarism.
Our database lists the following as having
Hypopituitarism as a symptom of that condition:
Related information on causes of Hypopituitarism:
As with all medical conditions,
there may be many causal factors.
Further relevant information on causes of Hypopituitarism may be found in:
Causes of Hypopituitarism: Online Medical Books
16 MEDICAL BOOKS ONLINE!
Review excerpts from medical books online, free, without registration,
for more information about the causes of Hypopituitarism.
Diabetes insipidus:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
Diabetes insipidus results centrally from intracranial neoplastic or metastatic lesions, hypophysectomy or other neurosurgery, a skull fracture, or head trauma that damages the neurohypophyseal structures. It can also result nephrogenically from infection, granulomatous disease, and vascular lesions; it may be idiopathic and, rarely, familial. (Note: Pituitary diabetes insipidus shouldn’t be confused with nephrogenic diabetes insipidus, a rare congenital disturbance of water metabolism that results from renal tubular resistance to vasopressin.)
Normally, the hypothalamus synthesizes vasopressin. The posterior pituitary gland (or neurohypophysis) stores vasopressin and releases it into general circulation, where it causes the kidneys to reabsorb water by making the distal tubules and collecting duct cells water-permeable. The absence of vasopressin in diabetes insipidus allows the filtered water to be excreted in the urine instead of being reabsorbed.
Nephrogenic diabetes insipidus involves a defect in the parts of the kidneys that reabsorb water back into the bloodstream. It occurs less commonly than central diabetes insipidus. Nephrogenic diabetes insipidus may occur as an inherited disorder in which male children receive the abnormal gene that causes the disease on the X chromosome from their mothers. Nephrogenic diabetes insipidus may also be caused by diseases of the kidney (such as polycystic kidney disease) and the effects of certain drugs (such as lithium and amphotericin B).
Diabetes insipidus is rare, affecting 1 in 25,000 people. Males and females are affected equally.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Hypopituitarism:
Causes
(Professional Guide to Diseases (Eighth Edition))
The most common cause of primary hypopituitarism in adults is a tumor. Other causes include congenital defects (hypoplasia or aplasia of the pituitary gland); pituitary infarction (most often from postpartum hemorrhage); or partial or total hypophysectomy by surgery, irradiation, or chemical agents; and, rarely, granulomatous disease (tuberculosis, for example). Occasionally, hypopituitarism may have no identifiable cause, or it may be related to autoimmune destruction of the gland. Secondary hypopituitarism stems from a deficiency of releasing hormones produced by the hypothalamus — either idiopathic or possibly resulting from infection, trauma, or a tumor.
Primary hypopituitarism usually develops in a predictable pattern of hormonal failures. It generally starts with hypogonadism from gonadotropin failure (decreased FSH and LH levels). In adults, it causes cessation of menses in females and impotence in men. Growth hormone (GH) deficiency follows; in children, this causes short stature, delayed growth, and delayed puberty. In adults, it causes osteoporosis, decreased lean-to-fat body mass index, adverse lipid changes, and subtle emotional dysphoria and lethargy. Subsequent failure of thyrotropin (decreased TSH levels) causes hypothyroidism; finally, adrenocorticotropic failure (decreased corticotropin levels) results in adrenal insufficiency. However, when hypopituitarism follows surgical ablation or trauma, the pattern of hormonal events may not necessarily follow this sequence. Sometimes, damage to the hypothalamus or neurohypophysis from one of the above leads to diabetes insipidus.
» READ BOOK EXCERPT ONLINE »
Source: Professional Guide to Diseases (Eighth Edition), 2005
Diabetes insipidus:
Causes
(Handbook of Diseases)
Pituitary diabetes insipidus results from intracranial neoplastic or metastatic lesions, hypophysectomy or other neurosurgery, a skull fracture, or head trauma that damages the neurohypophyseal structures. It can also result from infection, granulomatous disease, and vascular lesions; it may be idiopathic and, rarely, familial.
The hypothalamus synthesizes vasopressin. The posterior pituitary gland (or neurohypophysis) stores vasopressin and releases it into the general circulation, where it causes the kidneys to reabsorb water by making the distal tubules and collecting duct cells water-permeable.
In pituitary diabetes insipidus, the absence of vasopressin allows the filtered water to be excreted in the urine instead of being reabsorbed. In renal diabetes insipidus, the kidney doesn’t respond to vasopressin, which is usually present in high concentrations.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Hypopituitarism:
Causes
(Handbook of Diseases)
The most common cause of primary hypopituitarism is a tumor. Other causes include congenital defects (hypoplasia or aplasia of the pituitary gland); pituitary infarction (most commonly from postpartum hemorrhage); partial or total hypophysectomy by surgery, irradiation, or chemical agents; and, rarely, granulomatous disease (tuberculosis, for example). Occasionally, hypopituitarism may have no identifiable cause, or it may be related to autoimmune destruction of the gland. Secondary hypopituitarism stems from a deficiency of releasing hormones produced by the hypothalamus — either idiopathic or possibly resulting from infection, trauma, or a tumor.
Primary hypopituitarism usually develops in a predictable pattern of hormonal failures. It generally starts with hypogonadism from gonadotropin failure (decreased FSH and LH levels). In adults, it causes cessation of menses in women and impotence in men. hGH deficiency follows; in children, this causes short stature, delayed growth, and delayed puberty. Subsequent failure of thyrotropin (decreased TSH levels) causes hypothyroidism; finally, adrenocortical failure (decreased corticotropin levels) results in adrenal insufficiency. When hypopituitarism follows surgical ablation or trauma, the pattern of hormonal events may not necessarily follow this sequence.
Sometimes, damage to the hypothalamus or neurohypophysis from one of the above leads to diabetes insipidus.
» READ BOOK EXCERPT ONLINE »
Source: Handbook of Diseases, 2003
Tumors in the pituitary can release hormones that wreak havoc throughout the body. Listen to experts explain why shrinking tumors is an important...
Up to 10% of children in the United States have asthma, and asthma control is key to preventing long-term problems. National treatment guidelines...
For many people, the purpose of tanning is obvious: bronze is beautiful. But although a deep tan may get you compliments this summer, too much...
If you're a parent, you know that kids love to spend their days outdoors and this means hours and hours under the sun. What can you do to protect...
See full list of 4 related videos
» Next page: Symptoms of Hypopituitarism
Rate This Website
What do you think about the features of this website?
Take our user survey and have your say:
Website User Survey
Medical Tools & Articles:
Next articles:
Tools & Services:
Medical Articles:
Forums & Message Boards
- Ask or answer a question at the Boards:
