Clinical Trials for Hypotension

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Hypotension is grouped into the following categories:-

• View by trial name
• View by drugs used in Hypotension clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Hypotension:

• Phase II Study of Midodrine for Neurogenic Orthostatic Hypotension - This study has been completed (Current: 23 Nov 2006) - midodrine
• Droxidopa in Treating Patients With Neurogenic Hypotension - This study has been suspended (Current: 23 Nov 2006) - droxidopa
• Efficacy of Therapeutic Interventions for Orthostatic Hypotension in Parkinson's Disease and Multiple System Atrophy - This study has been completed (Current: 23 Nov 2006) - Fludrocortisone,Domperidone
• Treatment of Orthostatic Hypotension in Autonomic Failure - This study is currently recruiting patients (Current: 23 Nov 2006) - Atomoxetine 18 mg PO,Acarbose 100 mg,pyridostigmine 60 mg,Yohimbine 5.4 mg,midodrine,Nepro,placebo,modafinil 50 mg,Octreotide
• A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure - This study is currently recruiting patients (Current: 23 Nov 2006) - furosemide
• Orthostatic Hypotension in Rehabilitation Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Medication review by MD Pharmacist
• Safety of Dialysate Sodium Individualization in Hemodialysis Patients With Intradialytic Hypotension - This study is currently recruiting patients (Current: 23 Nov 2006) - dialysate sodium concentration
• Efficacy Study of a Facemask Device to Treat Hypotension - This study is currently recruiting patients (Current: 23 Nov 2006)
• Ideal Dose of Phenylephrine to Treat Low Blood Pressure During Cesarean Section - This study is currently recruiting patients (Current: 23 Nov 2006) - phenylephrine
• Dose-Response Study of Sodium Nitroprusside in Children Requiring Controlled Hypotension in the Operating Room - This study is currently recruiting patients (Current: 23 Nov 2006) - Sodium nitroprusside
• Evaluation of the Effects of L-Carnitine Injection in Patients Undergoing Hemodialysis - This study is currently recruiting patients (Current: 23 Nov 2006) - L-Carnitine Injection
• Prevention of Low Blood Pressure in Persons With Tetraplegia - This study is currently recruiting patients (Current: 23 Nov 2006) - N-Nitro L-arginine-methylester (L-NAME)
• Effect of Intradialytic Electrical Muscle Stimulation and Passive Leg Mobilisation on Blood Pressure and Dialysis Efficacy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Impedance Threshold Device Tilt Study - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension - This study has been terminated (Current: 23 Nov 2006) - midodrine hydrochloride (ProAmatine®)
• A Study for Patients With Neurogenic Orthostatic Hypotension - This study has been completed (Current: 23 Nov 2006) - Midodrine Hydrochloride
• Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion - This study is currently recruiting patients (Current: 23 Nov 2006) - Drotrecogin Alfa (Activated),placebo
• Processing and Effects of Cannabis - This study is currently recruiting patients (Current: 23 Nov 2006) - Smoking of cannabis cigarettes (different strength)
• Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants - This study is currently recruiting patients (Current: 23 Nov 2006) - Hydrocortisone
• Evaluation of M40403 for the Prevention of Dose Limiting Toxicities of High Dose IL-2 - This study has been suspended (Current: 23 Nov 2006) - M40403
• The Autonomic Nervous System and Obesity - This study is currently recruiting patients (Current: 23 Nov 2006) - trimethaphan
• Changes in Cerebral Oxygenation During Deliberate Hypotensive Anesthesia - This study is currently recruiting patients (Current: 23 Nov 2006)
• A Comparison of Prevention of Hypothermia in Pediatric Patient Between Wrapping With Cotton and Plastic. - This study has been completed (Current: 23 Nov 2006)
• Central Blood Volume in Hypotensive Dialysis Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Neurological Outcome of VLBW Infants With Early Hypotension - This study has been completed (Current: 23 Nov 2006)
• Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance - This study has been completed (Current: 23 Nov 2006) - Propranolol
• Nitrite Infusion in Healthy Volunteers - This study is currently recruiting patients (Current: 23 Nov 2006) - Sodium Nitrite
• Subcutaneous Amifostine Safety Study - This study has been completed (Current: 23 Nov 2006) - Amifostine administered subcutaneously
• Hemodynamic Measurements During Cesarean Section With Spinal Anesthesia - This study is currently recruiting patients (Current: 23 Nov 2006) - Phenylephrine
• Evaluation of a New Blood Pressure Measuring Device. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dopamine and Norepinephrine in Shock Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - dopamine versus norepinephrine
• Hemocontrol and Blood Pressure Control in Dialysis Patients - This study has been completed (Current: 23 Nov 2006)
• Orthostatic Tolerance During FES (Functional Electrical Stimulation)-Walking in Paraplegia - This study is currently recruiting patients (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Hypotension

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Hypotension:

• Acarbose 100 mg - Treatment of Orthostatic Hypotension in Autonomic Failure - This study is currently recruiting patients (Current: 23 Nov 2006)
• Amifostine administered subcutaneously - Subcutaneous Amifostine Safety Study - This study has been completed (Current: 23 Nov 2006)
• Atomoxetine 18 mg PO - Treatment of Orthostatic Hypotension in Autonomic Failure - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dialysate Sodium Concentration - Safety of Dialysate Sodium Individualization in Hemodialysis Patients With Intradialytic Hypotension - This study is currently recruiting patients (Current: 23 Nov 2006)
• Domperidone - Efficacy of Therapeutic Interventions for Orthostatic Hypotension in Parkinson's Disease and Multiple System Atrophy - This study has been completed (Current: 23 Nov 2006)
• Dopamine Versus Norepinephrine - Dopamine and Norepinephrine in Shock Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Drotrecogin Alfa (Activated) - Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion - This study is currently recruiting patients (Current: 23 Nov 2006)
• Droxidopa - Droxidopa in Treating Patients With Neurogenic Hypotension - This study has been suspended (Current: 23 Nov 2006)
• Fludrocortisone - Efficacy of Therapeutic Interventions for Orthostatic Hypotension in Parkinson's Disease and Multiple System Atrophy - This study has been completed (Current: 23 Nov 2006)
• Furosemide - Trial Assessing the Effect of Preoperative Furosemide on Intraoperative Blood Pressure - This study is currently recruiting patients (Current: 23 Nov 2006)
• Hydrocortisone - Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants - This study is currently recruiting patients (Current: 23 Nov 2006)
• L-Carnitine Injection - Evaluation of the Effects of L-Carnitine Injection in Patients Undergoing Hemodialysis - This study is currently recruiting patients (Current: 23 Nov 2006)
• M40403 - Evaluation of M40403 for the Prevention of Dose Limiting Toxicities of High Dose IL-2 - This study has been suspended (Current: 23 Nov 2006)
• Medication review by MD Pharmacist - Orthostatic Hypotension in Rehabilitation Patients - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Midodrine Hydrochloride (Proamatine®) - A Phase IV Study in Subjects With Neurogenic Orthostatic Hypotension - This study has been terminated (Current: 23 Nov 2006)
• Midodrine Hydrochloride - A Study for Patients With Neurogenic Orthostatic Hypotension - This study has been completed (Current: 23 Nov 2006)
• Midodrine - Phase II Study of Midodrine for Neurogenic Orthostatic Hypotension - This study has been completed (Current: 23 Nov 2006)
• Midodrine - Treatment of Orthostatic Hypotension in Autonomic Failure - This study is currently recruiting patients (Current: 23 Nov 2006)
• Modafinil 50 Mg - Treatment of Orthostatic Hypotension in Autonomic Failure - This study is currently recruiting patients (Current: 23 Nov 2006)
• N-Nitro L-arginine-methylester (L-NAME) - Prevention of Low Blood Pressure in Persons With Tetraplegia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nepro - Treatment of Orthostatic Hypotension in Autonomic Failure - This study is currently recruiting patients (Current: 23 Nov 2006)
• Octreotide - Treatment of Orthostatic Hypotension in Autonomic Failure - This study is currently recruiting patients (Current: 23 Nov 2006)
• Phenylephrine - Hemodynamic Measurements During Cesarean Section With Spinal Anesthesia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Phenylephrine - Ideal Dose of Phenylephrine to Treat Low Blood Pressure During Cesarean Section - This study is currently recruiting patients (Current: 23 Nov 2006)
• Placebo - Extended Therapy of Drotrecogin Alfa (Activated) 4 vs 7 Days Infusion - This study is currently recruiting patients (Current: 23 Nov 2006)
• Placebo - Treatment of Orthostatic Hypotension in Autonomic Failure - This study is currently recruiting patients (Current: 23 Nov 2006)
• Propranolol - Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance - This study has been completed (Current: 23 Nov 2006)
• Pyridostigmine 60 Mg - Treatment of Orthostatic Hypotension in Autonomic Failure - This study is currently recruiting patients (Current: 23 Nov 2006)
• Smoking of cannabis cigarettes (different strength) - Processing and Effects of Cannabis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sodium Nitrite - Nitrite Infusion in Healthy Volunteers - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sodium nitroprusside - Dose-Response Study of Sodium Nitroprusside in Children Requiring Controlled Hypotension in the Operating Room - This study is currently recruiting patients (Current: 23 Nov 2006)
• Trimethaphan - The Autonomic Nervous System and Obesity - This study is currently recruiting patients (Current: 23 Nov 2006)
• Yohimbine 5.4 mg - Treatment of Orthostatic Hypotension in Autonomic Failure - This study is currently recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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