Clinical Trials for Indigestion

Clinical trials are research studies conducted in an effort to improve overall patient health and care. Each trial involves running supervised tests to determine the effectiveness and safety of new drugs, procedures and/or devices with the aim of answering scientific questions about a disease or condition. Risks and side-effects are also evaluated during these trials with results ranging from being unpleasant, with side effects such as headaches, to more serious or even life-threatening risks. A clinical trial may be separated into phases, or steps, with each step designed to answer a separate research question. This maybe reflected in the trial name.

A brief description of each phase:

• Phase I: Usually designed to evaluate safety, determine a safe dosage range, and identify side effects on a small group of patients.
• Phase II: If Phase I is successful, the trial is then repeated with a larger group to further evaluate its effect and safety.
• Phase III: Trials are conducted on an ever larger group and are compared with the best current treatment while gathering more information on effect and safety.
• Phase IV: These studies monitor long-term side effects after the treatment has been marketed.

Clinical Trials data for Indigestion is grouped into the following categories:-

• View by trial name
• View by drugs used in Indigestion clinical trials

Clinical Trials by trial name

The format for each of the following is:

• The name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.
• followed by a list of drug/s, if any, used in the trial

ClinicalTrials.gov has listed the following trials for Indigestion:

• Effect of Itopride, on Symptoms of Functional Dyspepsia, Such as Indigestion, Bloating, Inability to Finish a Meal - This study is no longer recruiting patients (Current: 23 Nov 2006) - Itopride Hydrochloride
• Effect of Itopride, on Symptoms of Functional Dyspepsia, Such as Indigestion, Bloating, Inability to Finish a Meal - This study is currently recruiting patients (Current: 23 Nov 2006) - Itopride Hydrochloride
• Study of Long-Term Use of Proton-Pump-Inhibitors in General Practice - This study is currently recruiting patients (Current: 23 Nov 2006) - esomeprazole
• Long-Term Safety and Efficacy of Itopride Hydrochloride (HCl) in Patients Suffering From Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006) - Itopride hydrochloride
• Long-Term Safety and Efficacy of Itopride Hydrochloride (HCl) in Patients Suffering From Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006) - Itopride Hydrochloride
• Proton Pump Inhibitor Treatment Stop - This study is currently recruiting patients (Current: 23 Nov 2006) - esomeprazole
• Montelukast in the Treatment of Duodenal Eosinophilia - This study is currently recruiting patients (Current: 23 Nov 2006) - montelukast
• The Effects of Tegaserod on Mechanical Sensitivity of the Esophagus and Stomach in Patients With Heartburn and Dyspepsia. - This study is currently recruiting patients (Current: 23 Nov 2006) - Tegaserod
• The Role of Tegaserod Therapy in the Management of Dyspeptic Symptoms in Female Patients on Proton Pump Inhibitors for the Treatment of Heartburn. - This study is currently recruiting patients (Current: 23 Nov 2006) - Tegaserod
• Evaluation of Efficiency of Esophageal Capsule Endoscopy in the Screening of Patients With Gastroesophageal Reflux Disease or Dyspepsia as Compared to Upper Endoscopy - This study is currently recruiting patients (Current: 23 Nov 2006)
• Evaluation of Food Hypersensitivity in Children/Adolescents With Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Comparison of a "Step-Up" Versus a "Step-Down" Treatment Strategy for Patients With New Onset Dyspepsia in General Practice (the DIAMOND-Study). - This study is currently recruiting patients (Current: 23 Nov 2006) - step-up strategy: Algedrate-magnesiumoxide, in case of persisting/relapsing symptoms continued with ranitidine, if neccessary continued with pantoprazole.,step-down strategy: Pantoprazole, in case of persisting or relapsing symptoms continued with Ranitidine, if necessary continued with Algedrate-magnesiumoxide
• The Safety and Efficacy of Dexloxiglumide for the Relief of Symptoms of Functional Dyspepsia. - This study is currently recruiting patients (Current: 23 Nov 2006) - dexloxiglumide,Nexium (esomeprazole)
• Defining Central Circuits of Pain - This study is currently recruiting patients (Current: 23 Nov 2006)
• Assessment of Efficacy and Safety of Tegaserod Treatment and Placebo in Women With Dyspepsia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Tegaserod
• Extension Study to Assess the Long-Term Safety of Tegaserod in Women With Symptoms of Dyspepsia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Tegaserod
• Assessment of Efficacy and Safety of Tegaserod Treatment and Placebo in Women With Dyspepsia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Tegaserod
• Extension Study to Assess the Long-Term Safety of Tegaserod in Women With Symptoms of Dyspepsia - This study is no longer recruiting patients (Current: 23 Nov 2006) - Tegaserod
• Serotonin Effect in Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006) - venlafaxine
• YM443 in Subjects With Functional Dyspepsia - This study is no longer recruiting patients (Current: 23 Nov 2006) - YM443
• Inhibition of Gastric Acid is the Key to Satisfactory Relief of Symptoms With Esomeprazole in NUD Patients - This study is currently recruiting patients (Current: 23 Nov 2006) - Esomeprazole
• NAET Screening for Food Allergy, Sensitivity and Intolerances Using IgE-Specific Antigen Test and NST- NAET - This study has been completed (Current: 23 Nov 2006)
• The Efficacy of Imipramine in Treatment of Functional Dyspepsia: A Double Blind Randomized Placebo Controlled Trial - This study is currently recruiting patients (Current: 23 Nov 2006) - Imipramine
• Lymphocytic Subsets and Cytokine Production With H. Pylori Infection - This study has been completed (Current: 23 Nov 2006)
• HEARD (Long Term) Study Histology of the Esophagus in Acid-Related Disease - This study is currently recruiting patients (Current: 23 Nov 2006) - Esomeprazole
• Nexium Dyspepsia/AST - This study has been completed (Current: 23 Nov 2006) - Esomeprazole
• Nexium Dyspepsia/AST - This study has been completed (Current: 23 Nov 2006) - Esomeprazole
• Use of MRI for Assessing Stomach Relaxation in Response to a Meal - This study is currently recruiting patients (Current: 23 Nov 2006)
• Activation and Recruitment of GIL During Hp Infection - This study is currently recruiting patients (Current: 23 Nov 2006)
• Antibiotic Resistance Helicobacter Pylori in Rajavithi Hospital - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Gastric Motor Function Measurement in Dyspepsia and Normal Subjects - This study is currently recruiting patients (Current: 23 Nov 2006)
• The Effects of Z-338 in Subjects With and Without Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006) - Z-338
• Itopride in Functional Dyspepsia:a Dose Finding Study - This study has been completed (Current: 23 Nov 2006) - Itopride (drug)
• Intestinal Permeability in Children/Adolescents With Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Electrogastrogram (EGG) Reproducibility Study: EEG Readings in Normal Subjects and Dyspeptic Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• An Exploratory Study Examining The Effects Of Taking GW679769 Once-Daily For 4 Days In Patients With Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006) - GW679769 oral tablets
• NAET Testing Devices in Detection of Hypersensitivity to Cane Sugar - This study has been completed (Current: 23 Nov 2006)
• The Effects of Tegaserod Vs. Placebo on Whole Gut Transit Time in Patients With Chronic Constipation and Dyspepsia - This study was withdrawn prior to recruitment (Current: 23 Nov 2006) - Tegaserod and Placebo
• Tricyclic Antidepressants (TCAs) on Gastric Emptying - This study is currently recruiting patients (Current: 23 Nov 2006) - Desipramine,Amitriptyline
• Antidepressant Therapy for Functional Dyspepsia - This study is not yet open for patient recruitment (Current: 23 Nov 2006) - Amitriptyline; Escitalopram
• To Evaluate the Efficacy and Safety in Subjects With Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006) - Z-338
• To Evaluate the Efficacy of Z-338 in Subjects With Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006) - Z-338
• Helicobacter Pylori Eradication With a New Sequential Treatment - This study has been completed (Current: 23 Nov 2006) - Sequential therapy
• Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Placebo Controlled Trial of Botulinum Toxin for Gastroparesis - This study is currently recruiting patients (Current: 23 Nov 2006) - Botulinum toxin type A
• Patterns of Antiacids Use in Patients With IHD Admitted to Department of Internal Medicine - This study is currently recruiting patients (Current: 23 Nov 2006)

Drugs used in Clinical Trials for Indigestion

The format for each of the following is:

• The drug,
• followed by the name of the trial,
• followed by whether the trial is recruiting patients,
  - The trial may not have started and not yet recruiting, or the trial may have started and do not need any more recruitements, or the trial may be completed.
  - Note**: Please follow the link to determine the current trial status.

ClinicalTrials.gov has listed the following drugs in trials for Indigestion:

• Amitriptyline - Tricyclic Antidepressants (TCAs) on Gastric Emptying - This study is currently recruiting patients (Current: 23 Nov 2006)
• Amitriptyline; Escitalopram - Antidepressant Therapy for Functional Dyspepsia - This study is not yet open for patient recruitment (Current: 23 Nov 2006)
• Botulinum toxin type A - Placebo Controlled Trial of Botulinum Toxin for Gastroparesis - This study is currently recruiting patients (Current: 23 Nov 2006)
• Desipramine - Tricyclic Antidepressants (TCAs) on Gastric Emptying - This study is currently recruiting patients (Current: 23 Nov 2006)
• Dexloxiglumide - The Safety and Efficacy of Dexloxiglumide for the Relief of Symptoms of Functional Dyspepsia. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Esomeprazole - HEARD (Long Term) Study Histology of the Esophagus in Acid-Related Disease - This study is currently recruiting patients (Current: 23 Nov 2006)
• Esomeprazole - Inhibition of Gastric Acid is the Key to Satisfactory Relief of Symptoms With Esomeprazole in NUD Patients - This study is currently recruiting patients (Current: 23 Nov 2006)
• Esomeprazole - Nexium Dyspepsia/AST - This study has been completed (Current: 23 Nov 2006)
• Esomeprazole - Nexium Dyspepsia/AST - This study has been completed (Current: 23 Nov 2006)
• Esomeprazole - Proton Pump Inhibitor Treatment Stop - This study is currently recruiting patients (Current: 23 Nov 2006)
• Esomeprazole - Study of Long-Term Use of Proton-Pump-Inhibitors in General Practice - This study is currently recruiting patients (Current: 23 Nov 2006)
• GW679769 oral tablets - An Exploratory Study Examining The Effects Of Taking GW679769 Once-Daily For 4 Days In Patients With Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Imipramine - The Efficacy of Imipramine in Treatment of Functional Dyspepsia: A Double Blind Randomized Placebo Controlled Trial - This study is currently recruiting patients (Current: 23 Nov 2006)
• Itopride (drug) - Itopride in Functional Dyspepsia:a Dose Finding Study - This study has been completed (Current: 23 Nov 2006)
• Itopride Hydrochloride - Effect of Itopride, on Symptoms of Functional Dyspepsia, Such as Indigestion, Bloating, Inability to Finish a Meal - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Itopride Hydrochloride - Effect of Itopride, on Symptoms of Functional Dyspepsia, Such as Indigestion, Bloating, Inability to Finish a Meal - This study is currently recruiting patients (Current: 23 Nov 2006)
• Itopride Hydrochloride - Long-Term Safety and Efficacy of Itopride Hydrochloride (HCl) in Patients Suffering From Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Itopride hydrochloride - Long-Term Safety and Efficacy of Itopride Hydrochloride (HCl) in Patients Suffering From Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Montelukast - Montelukast in the Treatment of Duodenal Eosinophilia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Nexium (esomeprazole) - The Safety and Efficacy of Dexloxiglumide for the Relief of Symptoms of Functional Dyspepsia. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Sequential therapy - Helicobacter Pylori Eradication With a New Sequential Treatment - This study has been completed (Current: 23 Nov 2006)
• Step-Down Strategy: Pantoprazole, In Case Of Persisting Or Relapsing Symptoms Continued With Ranitidine, If Necessary Continued With Algedrate-Magnesiumoxide - Comparison of a "Step-Up" Versus a "Step-Down" Treatment Strategy for Patients With New Onset Dyspepsia in General Practice (the DIAMOND-Study). - This study is currently recruiting patients (Current: 23 Nov 2006)
• Step-Up Strategy: Algedrate-Magnesiumoxide, In Case Of Persisting/Relapsing Symptoms Continued With Ranitidine, If Neccessary Continued With Pantoprazole. - Comparison of a "Step-Up" Versus a "Step-Down" Treatment Strategy for Patients With New Onset Dyspepsia in General Practice (the DIAMOND-Study). - This study is currently recruiting patients (Current: 23 Nov 2006)
• Tegaserod and Placebo - The Effects of Tegaserod Vs. Placebo on Whole Gut Transit Time in Patients With Chronic Constipation and Dyspepsia - This study was withdrawn prior to recruitment (Current: 23 Nov 2006)
• Tegaserod - Assessment of Efficacy and Safety of Tegaserod Treatment and Placebo in Women With Dyspepsia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Tegaserod - Assessment of Efficacy and Safety of Tegaserod Treatment and Placebo in Women With Dyspepsia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Tegaserod - Extension Study to Assess the Long-Term Safety of Tegaserod in Women With Symptoms of Dyspepsia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Tegaserod - Extension Study to Assess the Long-Term Safety of Tegaserod in Women With Symptoms of Dyspepsia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Tegaserod - The Effects of Tegaserod on Mechanical Sensitivity of the Esophagus and Stomach in Patients With Heartburn and Dyspepsia. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Tegaserod - The Role of Tegaserod Therapy in the Management of Dyspeptic Symptoms in Female Patients on Proton Pump Inhibitors for the Treatment of Heartburn. - This study is currently recruiting patients (Current: 23 Nov 2006)
• Venlafaxine - Serotonin Effect in Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006)
• YM443 - YM443 in Subjects With Functional Dyspepsia - This study is no longer recruiting patients (Current: 23 Nov 2006)
• Z-338 - The Effects of Z-338 in Subjects With and Without Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Z-338 - To Evaluate the Efficacy and Safety in Subjects With Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006)
• Z-338 - To Evaluate the Efficacy of Z-338 in Subjects With Functional Dyspepsia - This study is currently recruiting patients (Current: 23 Nov 2006)

The trial data on this page has been sourced from

• The U.S. National Library of Medicine (NLM) together with ClinicalTrials.gov

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