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Causes of Interstitial lung disease
Causes of Interstitial lung disease (Diseases Database):
The follow list shows some of the possible medical causes of Interstitial lung disease that are listed by the Diseases Database:
- Pulmonary fibrosis
- Lymphocytic interstitial pneumonia
- Desquamative interstitial pneumonitis
- Coin lesion (chest x-ray)
- Pneumonia
- Extrinsic allergic alveolitis
- Fibrosing alveolitis, cryptogenic
- Bronchiolitis obliterans
- Bronchiolitis obliterans organizing pneumonia
Causes of Interstitial lung disease: Online Medical Books
16 MEDICAL BOOKS ONLINE! Review excerpts from medical books online, free, without registration, for more information about the causes of Interstitial lung disease.
Idiopathic bronchiolitis obliterans with organizing pneumonia:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
BOOP has no known cause. However, other forms of bronchiolitis obliterans and organizing pneumonia may be associated with specific diseases or situations, such as bone marrow, heart, or heart-lung transplantation; collagen vascular diseases, such as rheumatoid arthritis and systemic lupus erythematosus; inflammatory diseases, such as Crohn’s disease, ulcerative colitis, and polyarteritis nodosa; bacterial, viral, or mycoplasmal respiratory infections; inhalation of toxic gases; and drug therapy with amiodarone, bleomycin, penicillamine, or lomustine.
Much debate still exists about the various pathologies and classifications of bronchiolitis obliterans. Most patients with BOOP are between ages 50 and 60. Incidence is equally divided between men and women. A smoking history doesn’t seem to increase the risk of developing BOOP.
Pneumocystis carinii pneumonia:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
P. carinii, the cause of PCP, usually is classified as a protozoan, although some investigators consider it more closely related to fungi. The organism exists as a saprophyte in the lungs of humans and various animals as part of the normal flora in most healthy people. It becomes an aggressive pathogen in the immunocompromised patient. Impaired cell-mediated (T-cell) immunity is thought to be more important than impaired humoral (B-cell) immunity in predisposing the patient to PCP, but the immune defects involved are poorly understood. P. carinii becomes activated in immunocompromised patients when the CD4+ T-cell count falls below 200/µl.
P. carinii invades the lungs bilaterally and multiplies extracellularly. As the infestation grows, alveoli fill with organisms and exudate, impairing gas exchange. The alveoli hypertrophy and thicken progressively, eventually leading to extensive consolidation.
The primary transmission route seems to be air, although the organism is already present in most people. The incubation period probably lasts for 4 to 8 weeks.
Pneumonia:
Causes and incidence
(Professional Guide to Diseases (Eighth Edition))
Pneumonia can be classified in several ways:
❑ Microbiologic etiology — Pneumonia can be viral, bacterial, fungal, protozoan, mycobacterial, mycoplasmal, or rickettsial in origin. (See Types of pneumonia, pages 538 to 541.)
❑ Location — Bronchopneumonia involves distal airways and alveoli; lobular pneumonia, part of a lobe; and lobar pneumonia, an entire lobe.
❑ Type — Primary pneumonia results from inhalation or aspiration of a pathogen; it includes pneumococcal and viral pneumonia. Secondary pneumonia may follow initial lung damage from a noxious chemical or other insult (superinfection), or may result from hematogenous spread of bacteria from a distant focus.
Predisposing factors for bacterial and viral pneumonia include chronic illness and debilitation, cancer (particularly lung cancer), abdominal and thoracic surgery, atelectasis, common colds or other viral respiratory infections, such as acquired immunodeficiency syndrome, chronic respiratory disease (chronic obstructive pulmonary disease [COPD], asthma, bronchiectasis, and cystic fibrosis), influenza, smoking, malnutrition, alcoholism, sickle cell disease, tracheostomy, exposure to noxious gases, aspiration, and immunosuppressive therapy.
Predisposing factors for aspiration pneumonia include old age, debilitation, artificial airway use, nasogastric (NG) tube feedings, impaired gag reflex, poor oral hygiene, and decreased level of consciousness.
In elderly patients and patients who are debilitated, bacterial pneumonia may follow influenza or a common cold. Respiratory viruses are the most common cause of pneumonia in children ages 2 to 3. In school-age children, mycoplasma pneumonia is more common.
Pneumonia Variants:
Differential Overview
(Field Guide to Bedside Diagnosis)
❑ Streptococcus pneumoniae
❑ Mycoplasma pneumoniae
❑ Haemophilus influenzae
❑ Chlamydia pneumoniae
❑ Influenza virus
❑ Staphylococcus aureus
❑ Mycobacterium tuberculosis
❑ Legionella pneumophila
❑ Klebsiella pneumoniae
❑ Pneumocystis carinii
❑ Chlamydia psittaci
❑ Severe Acute Respiratory Syndrome (SARS)
❑ Hantavirus
Bronchiolitis obliterans with organizing pneumonia, idiopathic:
Causes
(Handbook of Diseases)
BOOP has no known cause. However, other forms of bronchiolitis obliterans and organizing pneumonia may be associated with specific diseases or situations, such as bone marrow, heart, or heart-lung transplantation; collagen vascular diseases, such as rheumatoid arthritis or systemic lupus erythematosus; inflammatory diseases, such as Crohn’s disease, ulcerative colitis, or polyarteritis nodosa; bacterial, viral, or mycoplasmal respiratory tract infections; inhalation of toxic gases; or drug therapy with amiodarone, bleomycin, penicillamine, or lomustine.
Pneumocystis carinii pneumonia:
Causes
(Handbook of Diseases)
P. carinii, the cause of PCP, usually is classified as a protozoan, although some investigators consider it more closely related to fungi. The organism exists as a saprophyte in the lungs of humans and various animals.
Part of the normal flora in most healthy people, P. carinii becomes an aggressive pathogen in the immunocompromised patient. Impaired cell-mediated (T-cell) immunity is thought to be more important than impaired humoral (B-cell) immunity in predisposing the patient to PCP; however, the immune defects involved are poorly understood.
The organism invades the lungs bilaterally and multiplies extracellularly. As the infestation grows, alveoli fill with organisms and exudate, impairing gas exchange. The alveoli hypertrophy and thicken progressively, eventually leading to extensive consolidation.
The primary transmission route seems to be air, although the organism is already resident in most people. The incubation period probably lasts 4 to 8 weeks.
Pneumonia:
Causes
(Handbook of Diseases)
Pneumonia can be classified in several ways:
❑ Microbiologic etiology — Pneumonia can be viral, bacterial, fungal, protozoal, mycobacterial, mycoplasmal, or rickettsial in origin.
❑ Location — Bronchopneumonia involves distal airways and alveoli; lobular pneumonia, part of a lobe; and lobar pneumonia, an entire lobe.
❑ Type — Primary pneumonia results from inhalation or aspiration of a pathogen; it includes pneumococcal and viral pneumonia. Secondary pneumonia may follow initial lung damage from a noxious chemical or other insult (superinfection), or may result from hematogenous spread of bacteria from a distant focus. (See Types of pneumonia, pages 650 to 653.)
Predisposing factors
Predisposing factors for bacterial and viral pneumonia include chronic illness and debilitation, cancer (particularly lung cancer), abdominal and thoracic surgery, atelectasis, common colds or other viral respiratory tract infections, chronic respiratory disease (chronic obstructive pulmonary disease [COPD], asthma, bronchiectasis, cystic fibrosis), influenza, smoking, malnutrition, alcoholism, sickle cell disease, tracheostomy, exposure to noxious gases, aspiration, and immunosuppressant therapy.
Predisposing factors for aspiration pneumonia include old age, debilitation, nasogastric (NG) tube feedings, impaired gag reflex, poor oral hygiene, and decreased level of consciousness.
Interstitial lung disease as a complication of other conditions:
Other conditions that might have Interstitial lung disease as a complication may, potentially, be an underlying cause of Interstitial lung disease. Our database lists the following as having Interstitial lung disease as a complication of that condition:
Interstitial lung disease as a symptom:
Conditions listing Interstitial lung disease as a symptom may also be potential underlying causes of Interstitial lung disease. Our database lists the following as having Interstitial lung disease as a symptom of that condition:
Related information on causes of Interstitial lung disease:
As with all medical conditions, there may be many causal factors. Further relevant information on causes of Interstitial lung disease may be found in:
» Next page: Symptoms of Interstitial lung disease
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- Symptoms of Interstitial lung disease
- Diagnostic Tests for Interstitial lung disease
- Diagnosis of Interstitial lung disease
- Signs of Interstitial lung disease
- Misdiagnosis of Interstitial lung disease
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